Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.0754 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.2139 | 0.372 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Onchocerca volvulus | 0.0032 | 0.4393 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2139 | 0.2052 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.5326 | 0.615 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.5326 | 0.616 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4678 | 0.4619 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.8073 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4393 | 0.4331 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.8073 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2139 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2139 | 0.2052 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4678 | 0.4619 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2139 | 0.1681 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5326 | 0.5275 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.2139 | 0.372 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.2139 | 0.1704 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.8073 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.4678 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.2139 | 0.1681 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.8867 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.4393 | 0.4856 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.4393 | 0.4842 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2139 | 0.2052 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.2139 | 0.372 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.2139 | 0.1704 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.2139 | 0.372 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.2139 | 0.372 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.0754 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.8073 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.2139 | 0.372 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.4678 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.