Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1511 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0933 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1511 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1511 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1511 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1511 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1511 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1511 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1511 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.1511 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0761 | 0.0151 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1511 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1511 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.1511 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1511 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1339 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1511 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1339 | 0.7743 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1511 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.075 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0933 | 0.2407 | 0.5 |
Leishmania major | p450 reductase, putative | 0.1511 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1511 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1511 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1511 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1511 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.075 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1511 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.