Detailed information for compound 1536459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.598 | Formula: C28H37NO3
  • H donors: 4 H acceptors: 3 LogP: 2.79 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1ccc(cc1)C#C[C@]1(O)CCC2[C@]1(C)CCC1C2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O
  • InChi: 1S/C28H37NO3/c1-26-11-8-21(30)15-20(26)16-24(31)25-22(26)9-12-27(2)23(25)10-14-28(27,32)13-7-18-3-5-19(17-29)6-4-18/h3-6,16,21-25,30-32H,8-12,14-15,17,29H2,1-2H3/t21-,22?,23?,24-,25?,26-,27-,28-/m0/s1
  • InChiKey: YCCLJGNLWYJWRA-ZYPAAHOVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0767 0.1374
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0217 0.0354
Leishmania major hypothetical protein, conserved 0.0026 0.031 0.0213
Echinococcus granulosus dna polymerase kappa 0.0039 0.078 0.1399
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1541 0.2813
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.2554 0.248
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0767 0.437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.031 1
Brugia malayi Pre-SET motif family protein 0.003 0.0471 0.0708
Echinococcus multilocularis zinc finger protein 0.002 0.0115 0.0163
Trichomonas vaginalis set domain proteins, putative 0.024 0.7648 0.7972
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1492 0.2243
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0921 0.0831
Onchocerca volvulus 0.0084 0.2318 0.2574
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.9569 1
Schistosoma mansoni hypothetical protein 0.0175 0.5408 1
Schistosoma mansoni hypothetical protein 0.0021 0.0151 0.0231
Brugia malayi Bromodomain containing protein 0.0076 0.2036 0.3061
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0099 0.0148
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0682 0.1216
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.078 0.1108
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0921 0.0831
Loa Loa (eye worm) hypothetical protein 0.0091 0.2554 0.3795
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0151 0.0156
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0767 0.0675
Brugia malayi Cytochrome P450 family protein 0.005 0.1142 0.1717
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.078 0.0719
Schistosoma mansoni hypothetical protein 0.0175 0.5408 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0694 0.124
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.078 0.139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0247 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0086 0.011
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1541 0.2813
Schistosoma mansoni bromodomain containing protein 0.0064 0.163 0.2978
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.2622 0.3897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1506 0.2748
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.031 0.0213
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0627 0.1078
Mycobacterium ulcerans hypothetical protein 0.0163 0.5 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.4436 0.438
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0086 0.0058
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.2318 0.4258
Schistosoma mansoni ap endonuclease 0.0019 0.0099 0.0133
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0694 0.124
Echinococcus granulosus zinc finger protein 0.002 0.0115 0.0163
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.078 0.0688
Leishmania major DNA polymerase eta, putative 0.0091 0.2554 0.248
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0099 0.0133
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.4386 0.8746
Loa Loa (eye worm) hypothetical protein 0.0039 0.0766 0.1087
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.078 0.0688
Entamoeba histolytica hypothetical protein 0.0037 0.0694 0.0629
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0921 0.0831
Schistosoma mansoni DNA polymerase eta 0.0091 0.2554 0.4696
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0217 0.0354
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.031 0.0213
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0247 0.7006
Trypanosoma brucei unspecified product 0.0039 0.078 0.0688
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1541 0.2942
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.011
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.2554 0.384
Loa Loa (eye worm) hypothetical protein 0.006 0.1492 0.2186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.1062 0.1923
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1541 0.2942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2622 0.4821
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0099 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0841 0.1265
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.1312
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.9569 1
Echinococcus multilocularis dna polymerase eta 0.0091 0.2554 0.4696
Echinococcus multilocularis GPCR, family 2 0.0019 0.0086 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1492 0.2186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2622 0.4821
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.078 0.1399
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.078 0.0688
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0086 0.011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.2622 0.3942
Loa Loa (eye worm) hypothetical protein 0.0041 0.0848 0.1211
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.078 0.139
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.1062 0.1923
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0767 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0363 0.0267
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.2318 0.4258
Loa Loa (eye worm) hypothetical protein 0.0084 0.2318 0.3438
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0247 0.0156
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.078 0.0719
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0086 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Trypanosoma brucei unspecified product 0.0027 0.0363 0.0267
Leishmania major DNA polymerase kappa, putative 0.0039 0.078 0.0688
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0099 0.0133
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1492 0.2243
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.078 0.1399
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.078 0.0688
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0682 0.1216
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.078 0.139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0471 0.0825
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1062 0.1923
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.1627 0.1544
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0767 0.0705
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0921 0.0831
Loa Loa (eye worm) hypothetical protein 0.0041 0.0841 0.1201
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0471 0.0825
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0247 0.0967
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0247 0.0302
Entamoeba histolytica hypothetical protein 0.0037 0.0694 0.0629
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.078 0.0688
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.3575 0.5341
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0247 0.0302
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.5 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0086 0.013
Echinococcus multilocularis geminin 0.0175 0.5408 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0694 0.124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.4436 0.438
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1506 0.2748
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0247 0.0967
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Entamoeba histolytica hypothetical protein 0.0037 0.0694 0.0629
Brugia malayi PHD-finger family protein 0.0025 0.0299 0.045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.078 0.0688
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.9569 1
Entamoeba histolytica hypothetical protein 0.0024 0.0247 0.0156
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.2318 0.3485
Trypanosoma brucei DNA polymerase eta, putative 0.0091 0.2554 0.248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0058
Schistosoma mansoni inositol monophosphatase 0.0039 0.0767 0.1374
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0247 0.2213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0086 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1062 0.1923
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1541 0.2813
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2622 0.4821
Brugia malayi hypothetical protein 0.0026 0.031 0.0466
Trypanosoma brucei unspecified product 0.0027 0.0363 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0471 0.0825
Onchocerca volvulus 0.024 0.7648 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0627 0.0919
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.031 0.5671
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.2318 0.4258
Schistosoma mansoni hypothetical protein 0.0041 0.0841 0.1513
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.078 0.1399
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0433 0.0754
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0767 0.1374
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1541 0.9436
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0471 0.2434
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0363 0.0267
Brugia malayi hypothetical protein 0.0037 0.0694 0.1044
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1541 0.2813
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0217 0.0354
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.078 0.0719
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.011
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0247 0.0302
Entamoeba histolytica hypothetical protein 0.0037 0.0694 0.0629
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0767 0.0675
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.3575 0.5341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.9569 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2622 0.4821
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.6651 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2622 0.4821
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.9569 1
Schistosoma mansoni ap endonuclease 0.0019 0.0099 0.0133
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.1246 0.1159
Toxoplasma gondii hypothetical protein 0.005 0.114 0.6811
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0064 0.1627 1
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.1142 0.1656
Loa Loa (eye worm) hypothetical protein 0.0072 0.1888 0.2786
Loa Loa (eye worm) inositol-1 0.0039 0.0767 0.1088
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Brugia malayi Bromodomain containing protein 0.0039 0.0764 0.1148
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0767 0.0705
Echinococcus multilocularis dna polymerase kappa 0.0039 0.078 0.1399
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.4386 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0767 0.0675
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0767 0.0675
Plasmodium vivax SET domain protein, putative 0.003 0.0471 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0247 0.3973
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0767 0.1363
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.078 0.1399
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.078 0.139
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1541 0.1457
Leishmania major DNA polymerase eta, putative 0.0064 0.1627 0.1544
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1541 0.2942
Schistosoma mansoni zinc finger protein 0.002 0.0115 0.0163
Loa Loa (eye worm) hypothetical protein 0.0048 0.1062 0.1535
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1541 0.2942
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0086 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.031 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.4436 0.438
Loa Loa (eye worm) hypothetical protein 0.0026 0.031 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0363 0.0267
Brugia malayi MH2 domain containing protein 0.0121 0.3575 0.5375
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.078 0.1173
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0767 0.0705
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.031 0.0213
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.011
Echinococcus granulosus dna polymerase eta 0.0091 0.2554 0.4696
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.078 0.0688
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0767 0.0705
Schistosoma mansoni inositol monophosphatase 0.0039 0.0767 0.1374
Giardia lamblia DINP protein human, muc B family 0.0039 0.078 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 1 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0247 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2622 0.4821
Brugia malayi Pre-SET motif family protein 0.0211 0.6651 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.031 0.1381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2622 0.4821
Schistosoma mansoni hypothetical protein 0.0037 0.0694 0.124
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.4386 0.8746
Brugia malayi Inositol-1 0.0039 0.0767 0.1153
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.078 0.0688
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.078 0.0688
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0247 0.0149
Echinococcus granulosus geminin 0.0175 0.5408 1
Echinococcus granulosus GPCR family 2 0.0019 0.0086 0.011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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