Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ingi protein (ORF1) | 0.003 | 0.0309 | 0.0242 |
Entamoeba histolytica | thymidine kinase, putative | 0.0241 | 0.6617 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.0241 | 0.6617 | 0.6593 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0023 | 0.0098 | 0.0044 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0069 | 0.0069 |
Trypanosoma brucei | ingi protein (ORF1) | 0.003 | 0.0309 | 0.0242 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0.0069 | 0.5 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0023 | 0.0098 | 0.0044 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0988 | 1 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0023 | 0.0098 | 0.0044 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0241 | 0.6617 | 1 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0043 | 0.0689 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0.0069 | 0.5 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0023 | 0.0098 | 0.0029 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0023 | 0.0098 | 0.0044 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0045 | 0.0745 | 0.1033 |
Trypanosoma brucei | unspecified product | 0.003 | 0.0309 | 0.0242 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0988 | 0.0988 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0073 | 0.1579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1579 | 0.5 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0988 | 1 |
Leishmania major | thymidine kinase, putative | 0.0241 | 0.6617 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0069 | 0.0069 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.0689 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.003 | 0.0309 | 0.0242 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0241 | 0.6617 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0355 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0241 | 0.6617 | 1 |
Giardia lamblia | Thymidine kinase | 0.0241 | 0.6617 | 1 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0043 | 0.0689 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0241 | 0.6617 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0241 | 0.6617 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.003 | 0.0309 | 0.0242 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0069 | 0.0069 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.