TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.422 | Formula: C22H23NO4
H donors: 0 H acceptors: 2 LogP: 5.15 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1c2ccc(cc2nc2c1cco2)OCC/C(=C/C(=O)C=C(C)C)/C
InChi: 1S/C22H23NO4/c1-14(2)11-16(24)12-15(3)7-9-26-17-5-6-18-20(13-17)23-22-19(8-10-27-22)21(18)25-4/h5-6,8,10-13H,7,9H2,1-4H3/b15-12+
InChiKey: UVJNNOXCXHNVCM-NTCAYCPXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.1538	0.1423
Schistosoma mansoni	transcription factor btf3	0.0037	0.0765	0.064
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1094	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0028	0.049	0.0704
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0781	0.1043
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.1538	0.1423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0433	0.0536
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0134	0.0131
Leishmania major	protein kinase, putative	0.0013	0.0082	0.0492
Echinococcus granulosus	survival motor neuron protein 1	0.0251	0.6913	0.6912
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0668	0.0962
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0134	0.0194
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0134	0.0076
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0013	0.0082	0.0078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0155	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0251	0.6913	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1094	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0026	0.046	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2762	0.3993
Loa Loa (eye worm)	intermediate filament protein	0.0057	0.1338	0.1932
Giardia lamblia	GTOR	0.0047	0.106	0.5
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0082	0.0026
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0668	0.0665
Schistosoma mansoni	lamin	0.0057	0.1338	0.122
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0134	0.0131
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0013	0.0082	0.0078
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0034	0.0687	0.5503
Onchocerca volvulus		0.0051	0.117	0.1585
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0016	0.0155	0.0972
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0078	0.1929	0.1926
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3842	0.5556
Brugia malayi	intermediate filament protein	0.0057	0.1338	0.1936
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0155	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0082	0.0113
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0047	0.106	0.1057
Echinococcus granulosus	GPCR family 2	0.0034	0.0668	0.0665
Echinococcus granulosus	aryl hydrocarbon receptor	0.0013	0.0082	0.0078
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1538	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0138	0.0004
Schistosoma mansoni	rotamase	0.0035	0.071	0.0584
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0629	0.0501
Brugia malayi	hypothetical protein	0.0251	0.6913	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.1242	1
Entamoeba histolytica	hypothetical protein	0.0115	0.2999	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.1242	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.2762	0.3993
Trichomonas vaginalis	rotamase, putative	0.0034	0.0687	0.0905
Trypanosoma brucei	PAB1-binding protein , putative	0.0054	0.1242	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0625	0.0622
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.0391	0.0388
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0082	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Trypanosoma cruzi	target of rapamycin kinase 3	0.0038	0.0783	0.628
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0013	0.0082	0.0078
Onchocerca volvulus		0.0057	0.1338	0.183
Brugia malayi	hypoxia-induced factor 1	0.0159	0.4259	0.6161
Schistosoma mansoni	hypothetical protein	0.0109	0.2843	0.2746
Echinococcus granulosus	expressed protein	0.0035	0.071	0.0707
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0082	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.1889
Brugia malayi	PAS domain containing protein	0.0051	0.1172	0.1696
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1094	0.0973
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0013	0.0082	0.0026
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0765	0.4957
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.002	0.0264	0.2085
Brugia malayi	Intermediate filament tail domain containing protein	0.0057	0.1338	0.1936
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0612	0.0796
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0047	0.106	0.8524
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0629	0.0625
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0082	0.0609
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0047	0.106	0.1614
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0082	0.0609
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0016	0.0155	0.1204
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0629	0.0501
Toxoplasma gondii	peptidylprolyl isomerase	0.0034	0.0687	0.4442
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1094	0.1091
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1591	0.1476
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0011	0.0006	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0082	0.0026
Schistosoma mansoni	hypothetical protein	0.0115	0.2999	0.2904
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0577	0.083
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0765	0.6141
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0512	0.0651
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0035	0.071	0.1028
Echinococcus multilocularis	Ankyrin	0.0015	0.0138	0.0135
Trichomonas vaginalis	guanylate cyclase, putative	0.0013	0.0082	0.0026
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0082	0.0492
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0781	0.1043
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0016	0.0155	0.0972
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0057	0.1338	0.1932
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0016	0.0155	0.0021
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0765	0.0762
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.071	0.094
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1094	0.0973
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0082	0.0026
Schistosoma mansoni	intermediate filament proteins	0.0057	0.1338	0.122
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0577	0.0835
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0134	0.000000064252
Onchocerca volvulus		0.0032	0.0629	0.0797
Schistosoma mansoni	hypothetical protein	0.0034	0.0668	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0155	0.0133
Entamoeba histolytica	hypothetical protein	0.0115	0.2999	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.106	0.1447
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0016	0.0155	0.1204
Echinococcus multilocularis	lamin dm0	0.0057	0.1338	0.1335
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0034	0.0687	0.5503
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0434	0.0537
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.2762	0.3996
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.1538	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Schistosoma mansoni	cpg binding protein	0.0032	0.0625	0.0497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0512	0.0651
Loa Loa (eye worm)	phosphatidylinositol 3	0.0047	0.106	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1242	0.1793
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1538	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0047	0.106	0.1057
Toxoplasma gondii	LsmAD domain-containing protein	0.0054	0.1242	0.8071
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0078	0.1929	0.1926
Trichomonas vaginalis	adenylate cyclase, putative	0.0013	0.0082	0.0026
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0134	0.0189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0582	0.0753
Entamoeba histolytica	hypothetical protein	0.0037	0.0765	0.0341
Brugia malayi	hypothetical protein	0.0054	0.1242	0.1797
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0629	0.4063
Brugia malayi	MH2 domain containing protein	0.0144	0.3842	0.5558
Schistosoma mansoni	hypothetical protein	0.0051	0.117	0.105
Schistosoma mansoni	survival motor neuron protein	0.0051	0.117	0.105
Trichomonas vaginalis	guanylate cyclase, putative	0.0013	0.0082	0.0026
Echinococcus granulosus	transcription factor btf3	0.0037	0.0765	0.0762
Schistosoma mansoni	single-minded	0.0051	0.1172	0.1052
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0668	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1793	0.259
Onchocerca volvulus		0.0057	0.1338	0.183
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0016	0.0155	0.0152
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0629	0.0625
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0134	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0155	0.0133
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0134	0.0194
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0781	0.1043
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0016	0.0155	0.0225
Echinococcus granulosus	single minded 2	0.0038	0.0789	0.0786
Brugia malayi	hypothetical protein	0.0172	0.4642	0.6715
Echinococcus multilocularis	musashi	0.0057	0.1338	0.1335
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.106	0.1447
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0765	0.4957
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0047	0.106	0.0938
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0433	0.0536
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0433	0.0536
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.1069	0.1542
Brugia malayi	Uncoordinated protein 44	0.0015	0.0134	0.0194
Schistosoma mansoni	hypothetical protein	0.0034	0.0668	0.0541
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.1538	0.5
Brugia malayi	Pre-SET motif family protein	0.0032	0.0629	0.0909
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0343	0.2719
Schistosoma mansoni	hypothetical protein	0.0024	0.0391	0.026
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1094	0.1583
Schistosoma mansoni	lamin	0.0057	0.1338	0.122
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0765	0.2229
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1538	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0668	0.0967
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0781	0.1043
Leishmania major	hypothetical protein, conserved	0.0054	0.1242	0.8071
Entamoeba histolytica	hypothetical protein	0.0115	0.2999	1
Echinococcus granulosus	Ankyrin	0.0015	0.0138	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0134	0.0189
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0115	0.2999	0.2997
Schistosoma mansoni	aryl hydrocarbon receptor	0.0051	0.1172	0.1052
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0765	0.1103
Brugia malayi	hypothetical protein	0.0115	0.2999	0.4339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.106	0.1447
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0034	0.0687	0.5503
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0082	0.0609
Trichomonas vaginalis	rotamase, putative	0.0035	0.071	0.094
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0038	0.0783	0.628
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0629	0.0625
Echinococcus granulosus	lamin dm0	0.0057	0.1338	0.1335
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0035	0.0711	0.4602
Schistosoma mansoni	hypothetical protein	0.0073	0.1793	0.1681
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0576	0.0573
Brugia malayi	Pre-SET motif family protein	0.0222	0.6067	0.8777
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0765	0.1019
Schistosoma mansoni	cpg binding protein	0.003	0.0575	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0082	0.0026
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.1242	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0668	0.0541
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1392	0.9049
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0016	0.0155	0.1204
Schistosoma mansoni	cpg binding protein	0.0032	0.0625	0.0497
Brugia malayi	hypothetical protein	0.0035	0.0695	0.1006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0629	0.0501
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.1242	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0668	0.0541
Trichomonas vaginalis	set domain proteins, putative	0.0252	0.6944	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0765	0.6141
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.1793	0.2594
Brugia malayi	beta-NAC-like protein	0.0037	0.0765	0.1107
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0575	0.0827
Mycobacterium leprae	Possible regulatory protein	0.0013	0.0082	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0082	0.0026
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0134	0.0131
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0082	0.0609
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0047	0.106	0.1533
Onchocerca volvulus		0.0038	0.0789	0.103
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.1538	0.1535
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.1538	0.1535
Brugia malayi	bHLH-PAS transcription factor	0.0038	0.0789	0.1142
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.117	0.1693
Echinococcus granulosus	intermediate filament protein	0.0057	0.1338	0.1335
Entamoeba histolytica	hypothetical protein	0.0115	0.2999	1
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0765	0.1019
Echinococcus granulosus	lamin	0.0057	0.1338	0.1335
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1094	0.1091
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0159	0.4259	0.6159
Echinococcus multilocularis	survival motor neuron protein 1	0.0251	0.6913	0.6912
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0082	0.0609
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0047	0.106	0.8524
Echinococcus multilocularis	lamin	0.0057	0.1338	0.1335
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0668	0.0967
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0047	0.106	0.8524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0781	0.1043
Echinococcus multilocularis	geminin	0.0358	1	1
Brugia malayi	Cytochrome P450 family protein	0.0048	0.1069	0.1546
Onchocerca volvulus		0.003	0.0575	0.0718
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0765	0.6141
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0013	0.0082	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0115	0.2999	0.2904
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0668	0.0665
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0047	0.106	0.1614
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1094	0.1091
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0047	0.106	0.6879
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0765	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0026	0.046	0.0661
Loa Loa (eye worm)	phosphatidylinositol 3	0.0016	0.0155	0.022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0434	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0434	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0512	0.0651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0504	0.064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0115	0.2999	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0172	0.4642	0.6713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0504	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0765	0.1019
Echinococcus multilocularis	cpg binding protein	0.0032	0.0625	0.0622
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0668	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0861	0.1158
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3842	0.5556
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0629	0.0905
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.049	0.0487
Plasmodium vivax	ataxin-2 like protein, putative	0.0054	0.1242	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0434	0.0537
Echinococcus granulosus	death domain containing protein	0.0015	0.0134	0.0131
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.0391	0.0388
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.6067	0.8776
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0155	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.0941
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0013	0.0082	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1338	0.1932
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0668	0.0665
Echinococcus multilocularis	transfer RNA-Lys	0.0038	0.0789	0.0786
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0047	0.106	0.8524
Brugia malayi	Death domain containing protein	0.0015	0.0134	0.0194
Leishmania major	protein kinase, putative	0.0013	0.0082	0.0492
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0629	0.0501
Echinococcus multilocularis	expressed protein	0.0035	0.071	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0138	0.0195
Brugia malayi	CXXC zinc finger family protein	0.003	0.0575	0.0832
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0047	0.106	0.6879
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.2762	0.3996
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0035	0.071	0.1023
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.049	0.0487
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0038	0.0783	0.5068
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0034	0.0687	0.4442
Onchocerca volvulus		0.0252	0.6948	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0668	0.0962
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0013	0.0082	0.0026
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.1538	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0016	0.0155	0.0152
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1094	0.0973
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0016	0.0155	0.1204

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1902812

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1536498