Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0193 | 1 | 0.5 | |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0045 | 0.074 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0129 | 0.5998 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0045 | 0.074 | 1 |
Treponema pallidum | NADH oxidase | 0.0045 | 0.074 | 1 |
Onchocerca volvulus | 0.0193 | 1 | 0.5 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.9125 | 0.7815 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0193 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0129 | 0.5998 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0045 | 0.074 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0129 | 0.5998 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0045 | 0.074 | 0.0782 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0129 | 0.5998 | 0.9903 |
Toxoplasma gondii | thioredoxin reductase | 0.0129 | 0.5998 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0085 | 0.3262 | 0.475 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0129 | 0.6049 | 1 |
Onchocerca volvulus | 0.0193 | 1 | 0.5 | |
Echinococcus granulosus | glutamate receptor NMDA | 0.0077 | 0.2794 | 0.3868 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0045 | 0.074 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0129 | 0.5998 | 0.9903 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0045 | 0.074 | 0.0782 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0045 | 0.074 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0052 | 0.1208 | 0.0881 |
Trypanosoma brucei | trypanothione reductase | 0.0129 | 0.5998 | 1 |
Leishmania major | trypanothione reductase | 0.0129 | 0.5998 | 1 |
Brugia malayi | glutathione reductase | 0.0129 | 0.5998 | 0.5998 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0045 | 0.074 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0085 | 0.3262 | 0.475 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0129 | 0.5998 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0129 | 0.5998 | 0.5998 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0045 | 0.074 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0129 | 0.5998 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0045 | 0.074 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0045 | 0.074 | 0.074 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0077 | 0.2794 | 0.3868 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0045 | 0.074 | 0.5 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0045 | 0.074 | 0.0782 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 0.074 | 0.0782 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0099 | 0.4176 | 0.371 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0045 | 0.074 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0129 | 0.5998 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0129 | 0.6049 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 50.44 uM | PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.