TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 301.377 | Formula: C14H20FNO3S
H donors: 0 H acceptors: 2 LogP: 2.05 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC[C@H]1COCCS(=O)(=O)N1Cc1cccc(c1)F
InChi: 1S/C14H20FNO3S/c1-2-4-14-11-19-7-8-20(17,18)16(14)10-12-5-3-6-13(15)9-12/h3,5-6,9,14H,2,4,7-8,10-11H2,1H3/t14-/m0/s1
InChiKey: ZALWHYAFQMVRDX-AWEZNQCLSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Echinococcus multilocularis	protein lin 7 B	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0148	0.0943
Brugia malayi	interleukin-16	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0148	0.0148
Schistosoma mansoni	cell polarity protein	0.004	0.0139	0.0139
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0148	0.0148
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0148	0.0943
Mycobacterium ulcerans	oxygenase	0.0178	0.1034	0.0899
Onchocerca volvulus		0.0041	0.0148	0.0101
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.1568	1	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	multiple pdz domain protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Leishmania major	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.004	0.0139	0.0139
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0178	0.1034	0.2109
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Echinococcus multilocularis	multiple pdz domain protein	0.004	0.0139	0.0139
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0178	0.1034	0.1034
Echinococcus granulosus	methionine synthase reductase	0.0968	0.6131	0.6131
Toxoplasma gondii	flavodoxin domain-containing protein	0.0778	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	PDZ domain-containing protein	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Possible oxygenase	0.0178	0.1034	0.6581
Echinococcus multilocularis	partitioning defective 3	0.004	0.0139	0.0139
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0968	0.6131	0.6131
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.004	0.0139	0.0139
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0178	0.1034	0.1034
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Echinococcus multilocularis	membrane associated guanylate kinase, WW and PDZ	0.004	0.0139	0.0139
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0178	0.1034	0.2109
Schistosoma mansoni	hypothetical protein	0.0205	0.1204	0.1204
Echinococcus multilocularis	rho guanine nucleotide exchange factor 12	0.004	0.0139	0.0139
Echinococcus granulosus	55 kDa erythrocyte membrane protein	0.004	0.0139	0.0139
Echinococcus granulosus	peripheral plasma membrane protein CASK	0.004	0.0139	0.0139
Echinococcus multilocularis	multiple pdz domain protein	0.004	0.0139	0.0139
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0178	0.1034	0.1034
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0178	0.1034	0.1034
Schistosoma mansoni	pdz domain containing protein	0.004	0.0139	0.0139
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.004	0.0139	0.0139
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.0155	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.0155	0.0316
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0148	0.0943
Trypanosoma brucei	nitrate reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	inositol-1	0.0042	0.0155	0.0155
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.1568	1	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0968	0.6131	0.6131
Schistosoma mansoni	sap-97	0.004	0.0139	0.0139
Brugia malayi	Synapse defective protein 1	0.004	0.0139	0.0139
Giardia lamblia	Nitric oxide synthase, inducible	0.139	0.885	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0155	0.0007
Loa Loa (eye worm)	cell junction protein LIN-7	0.004	0.0139	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.022	0.022
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0148	0.0148
Echinococcus granulosus	cytochrome b5 reductase 4	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.1568	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0148	0.0943
Entamoeba histolytica	type A flavoprotein, putative	0.06	0.3754	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.1568	1	1
Echinococcus granulosus	partitioning defective 3	0.004	0.0139	0.0139
Loa Loa (eye worm)	RasGEF domain-containing protein	0.004	0.0139	0.0139
Echinococcus multilocularis	ligand of numb protein x 2	0.004	0.0139	0.0139
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0148	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.022	0.022
Loa Loa (eye worm)	9ORF binding protein 1	0.004	0.0139	0.0139
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.004	0.0139	0.0139
Brugia malayi	beta-lactamase family protein	0.0041	0.0148	0.0148
Mycobacterium tuberculosis	Probable monooxygenase	0.0178	0.1034	0.6581
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.004	0.0139	0.0139
Echinococcus multilocularis	protein piccolo	0.004	0.0139	0.0139
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	cytochrome P450 reductase	0.1568	1	1
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.004	0.0139	0.0139
Brugia malayi	gopc protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.1568	1	1
Brugia malayi	cell junction protein LIN-7	0.004	0.0139	0.0139
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Brugia malayi	Patj homolog	0.004	0.0139	0.0139
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	leucine-rich repeat protein	0.004	0.0139	0.0139
Echinococcus multilocularis	tight junction protein ZO 3	0.004	0.0139	0.0139
Schistosoma mansoni	multiple pdz domain protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0148	0.0148
Plasmodium falciparum	nitric oxide synthase, putative	0.1568	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0178	0.1034	0.6581
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	tight junction protein ZO 3	0.004	0.0139	0.0139
Brugia malayi	FAD binding domain containing protein	0.0968	0.6131	0.6131
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Brugia malayi	9ORF binding protein 1	0.004	0.0139	0.0139
Brugia malayi	PDZ domain	0.004	0.0139	0.0139
Loa Loa (eye worm)	peripheral plasma membrane protein CASK	0.004	0.0139	0.0139
Echinococcus multilocularis	pdz domain containing protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0148	0.0148
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0178	0.1034	0.6581
Loa Loa (eye worm)	X11 protein	0.004	0.0139	0.0139
Schistosoma mansoni	cell polarity protein	0.004	0.0139	0.0139
Mycobacterium ulcerans	monooxygenase	0.0178	0.1034	0.0899
Brugia malayi	gamma-syntrophin-like protein SYN2	0.004	0.0139	0.0139
Mycobacterium ulcerans	oxidoreductase	0.0178	0.1034	0.0899
Schistosoma mansoni	discs lost-related	0.004	0.0139	0.0139
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.139	0.885	0.8833
Toxoplasma gondii	ABC1 family protein	0.0041	0.0148	0.0302
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.004	0.0139	0.0139
Echinococcus multilocularis	MAGUK p55 subfamily	0.004	0.0139	0.0139
Echinococcus multilocularis	myeloid:lymphoid or mixed lineage leukemia	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0148	0.0148
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0922	0.5832	0.5832
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.0155	0.0007
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0178	0.1034	0.1494
Loa Loa (eye worm)	guanylate kinase	0.004	0.0139	0.0139
Schistosoma mansoni	MAGUK homolog	0.004	0.0139	0.0139
Brugia malayi	beta-lactamase family protein	0.0041	0.0148	0.0148
Leishmania major	p450 reductase, putative	0.1568	1	1
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0178	0.1034	0.1034
Schistosoma mansoni	multiple pdz domain protein	0.004	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.0205	0.1204	0.1204
Echinococcus granulosus	cell polarity protein	0.004	0.0139	0.0139
Brugia malayi	protein kinase C-binding protein PICK1	0.004	0.0139	0.0139
Schistosoma mansoni	multiple pdz domain protein	0.004	0.0139	0.0139
Brugia malayi	PDZ domain containing protein	0.004	0.0139	0.0139
Giardia lamblia	Hypothetical protein	0.139	0.885	1
Echinococcus granulosus	pdz domain containing protein	0.004	0.0139	0.0139
Onchocerca volvulus		0.0041	0.0148	0.0101
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.06	0.3754	0.3754
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	Rho GTPase activating protein 21	0.004	0.0139	0.0139
Echinococcus multilocularis	pdz domain containing protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Entamoeba histolytica	type A flavoprotein, putative	0.06	0.3754	1
Brugia malayi	PDZ domain containing protein	0.004	0.0139	0.0139
Schistosoma mansoni	multiple pdz domain protein	0.004	0.0139	0.0139
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0148	0.0148
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.1568	1	1
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0814	0.0814
Schistosoma mansoni	amyloid beta A4 protein related	0.004	0.0139	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.022	0.022
Brugia malayi	Partitioning defective-6 homolog alpha	0.004	0.0139	0.0139
Schistosoma mansoni	syntenin	0.004	0.0139	0.0139
Echinococcus multilocularis	segment polarity protein dishevelled	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0038	0.0127	0.0806
Schistosoma mansoni	afadin (af-6 protein)	0.004	0.0139	0.0139
Leishmania major	nitrate reductase, putative	0.0178	0.1034	0.1034
Brugia malayi	PDZ-domain protein scribble	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Schistosoma mansoni	maguk P55 subfamily member 26	0.004	0.0139	0.0139
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.1568	1	1
Echinococcus granulosus	pdz domain containing protein	0.004	0.0139	0.0139
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.1568	1	1
Schistosoma mansoni	lin-7-like proteins	0.004	0.0139	0.0139
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.004	0.0139	0.0139
Leishmania major	hypothetical protein, conserved	0.06	0.3754	0.3754
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0155	0.0155
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.06	0.3754	0.3754
Echinococcus multilocularis	peripheral plasma membrane protein CASK	0.004	0.0139	0.0139
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0155	0.0007
Echinococcus granulosus	segment polarity protein dishevelled	0.004	0.0139	0.0139
Brugia malayi	DIX domain containing protein	0.004	0.0139	0.0139
Echinococcus multilocularis	Na(+):H(+) exchange regulatory cofactor NHE RF2	0.004	0.0139	0.0139
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	guanylate kinase	0.004	0.0139	0.0139
Echinococcus granulosus	disks large 3	0.004	0.0139	0.0139
Schistosoma mansoni	NADPH flavin oxidoreductase	0.079	0.4981	0.4981
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.06	0.3754	0.366
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	protein kinase C alpha binding protein	0.004	0.0139	0.0139
Brugia malayi	microtubule-associated serine/threonine protein kinase 2 (MAST2)	0.004	0.0139	0.0139
Echinococcus granulosus	protein lin 7 B	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0148	0.0943
Echinococcus granulosus	Microtubule-associated serine/threonine-protein kinase	0.004	0.0139	0.0139
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0155	0.0155
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0178	0.1034	0.1034
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.004	0.0139	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.022	0.022
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.004	0.0139	0.0139
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Echinococcus granulosus	geminin	0.0205	0.1204	0.1204
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.004	0.0139	0.0139
Brugia malayi	Inositol-1	0.0042	0.0155	0.0155
Brugia malayi	PDZ domain containing protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Echinococcus multilocularis	Rho GTPase activating protein 21	0.004	0.0139	0.0139
Brugia malayi	RasGEF domain containing protein	0.004	0.0139	0.0139
Entamoeba histolytica	type A flavoprotein, putative	0.06	0.3754	1
Echinococcus granulosus	Na:H exchange regulatory cofactor NHE RF2	0.004	0.0139	0.0139
Echinococcus granulosus	multiple pdz domain protein	0.004	0.0139	0.0139
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.004	0.0139	0.0139
Echinococcus multilocularis	methionine synthase reductase	0.0968	0.6131	0.6131
Trypanosoma cruzi	reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Brugia malayi	hypothetical protein	0.004	0.0139	0.0139
Echinococcus granulosus	ligand of numb protein x 2	0.004	0.0139	0.0139
Brugia malayi	Protein-tyrosine phosphatase 1	0.004	0.0139	0.0139
Leishmania major	reductase, putative	0.0178	0.1034	0.1034
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0178	0.1034	0.1034
Schistosoma mansoni	PDZ domain protein	0.004	0.0139	0.0139
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.06	0.3754	0.3754
Loa Loa (eye worm)	diaphorase	0.0178	0.1034	0.1034
Echinococcus multilocularis	multiple pdz domain protein	0.004	0.0139	0.0139
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.1568	1	1
Brugia malayi	PDZ domain containing protein	0.004	0.0139	0.0139
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Echinococcus multilocularis	cell polarity protein leucine rich repeat	0.004	0.0139	0.0139
Schistosoma mansoni	dishevelled	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Echinococcus granulosus	MAGUK p55 subfamily	0.004	0.0139	0.0139
Echinococcus granulosus	glutamate receptor interacting protein 1	0.004	0.0139	0.0139
Echinococcus multilocularis	pdz domain containing protein	0.004	0.0139	0.0139
Onchocerca volvulus		0.0041	0.0148	0.0101
Echinococcus multilocularis	beta 1 syntrophin	0.004	0.0139	0.0139
Loa Loa (eye worm)	FAD binding domain-containing protein	0.1568	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.06	0.3754	0.366
Echinococcus multilocularis	PRKCA binding protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0155	0.0155
Brugia malayi	diaphorase	0.0178	0.1034	0.1034
Schistosoma mansoni	lim domain	0.004	0.0139	0.0139
Echinococcus granulosus	Partitioning defective 3 protein B	0.004	0.0139	0.0139
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.06	0.3754	0.3754
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0178	0.1034	0.6581
Schistosoma mansoni	Patj homolog	0.004	0.0139	0.0139
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.004	0.0139	0.0139
Brugia malayi	Abnormal embryonic partitioning of cytoplasm protein 3	0.004	0.0139	0.0139
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.004	0.0139	0.0139
Brugia malayi	Ferm domain	0.004	0.0139	0.0139
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0155	0.0155
Trypanosoma cruzi	p450 reductase, putative	0.1568	1	1
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0148	0.0943
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.06	0.3754	0.3754
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.1568	1	1
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.1568	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.022	0.022
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0262	0.1571	1
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0148	0.0943
Brugia malayi	Guanylate kinase family protein	0.004	0.0139	0.0139
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.004	0.0139	0.0139
Echinococcus granulosus	syndecan binding protein syntenin	0.004	0.0139	0.0139
Echinococcus multilocularis	MAGUK p55 subfamily	0.004	0.0139	0.0139
Chlamydia trachomatis	sulfite reductase	0.0968	0.6131	1
Schistosoma mansoni	discs large	0.004	0.0139	0.0139
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0148	0.0148
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0148	0.0148
Echinococcus granulosus	partitioning defective 3	0.004	0.0139	0.0139
Brugia malayi	Neurabin protein 1	0.004	0.0139	0.0139
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	leucine-rich repeat protein	0.004	0.0139	0.0139
Echinococcus granulosus	amyloid beta A4 protein	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0148	0.0943
Leishmania major	cytochrome P450 reductase, putative	0.139	0.885	0.885
Onchocerca volvulus		0.0178	0.1034	1
Brugia malayi	hypothetical protein	0.004	0.0139	0.0139
Brugia malayi	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.06	0.3754	0.366
Brugia malayi	PX domain containing protein	0.004	0.0139	0.0139
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.004	0.0139	0.0139
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.0155	0.0155
Echinococcus multilocularis		0.004	0.0139	0.0139
Echinococcus granulosus	beta 1 syntrophin	0.004	0.0139	0.0139
Echinococcus granulosus	MAGUK p55 subfamily	0.004	0.0139	0.0139
Brugia malayi	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Entamoeba histolytica	type A flavoprotein, putative	0.06	0.3754	1
Trypanosoma brucei	oxidoreductase-protein, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	pdz and lim domain protein	0.004	0.0139	0.0139
Schistosoma mansoni	cell polarity protein	0.004	0.0139	0.0139
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.004	0.0139	0.0139
Schistosoma mansoni	diflavin oxidoreductase	0.0778	0.4904	0.4904
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Echinococcus multilocularis	segment polarity protein dishevelled	0.004	0.0139	0.0139
Echinococcus granulosus	neurabin 1	0.004	0.0139	0.0139
Loa Loa (eye worm)	PX domain-containing protein	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0148	0.0943
Plasmodium vivax	hypothetical protein, conserved	0.06	0.3754	0.3754
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0155	0.0155
Brugia malayi	syntenin	0.004	0.0139	0.0139
Echinococcus granulosus	pdz domain containing protein	0.004	0.0139	0.0139
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0148	0.0943
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.022	0.022
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0178	0.1034	0.1034
Echinococcus granulosus	membrane associated guanylate kinase, WW and PDZ	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	gopc protein	0.004	0.0139	0.0139
Schistosoma mansoni	MAGUK homolog	0.004	0.0139	0.0139
Brugia malayi	rho guanine nucleotide exchange factor 12	0.004	0.0139	0.0139
Echinococcus multilocularis	geminin	0.0205	0.1204	0.1204
Trypanosoma cruzi	nitrate reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	rho guanine nucleotide exchange factor 12	0.004	0.0139	0.0139
Loa Loa (eye worm)	DIX domain-containing protein	0.004	0.0139	0.0139
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Echinococcus multilocularis	neurabin 1	0.004	0.0139	0.0139
Echinococcus granulosus	segment polarity protein dishevelled	0.004	0.0139	0.0139
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Echinococcus multilocularis	partitioning defective 3	0.004	0.0139	0.0139
Mycobacterium ulcerans	flavodoxin oxidoreductase	0.0178	0.1034	0.0899
Echinococcus multilocularis	microtubule associated serine:threonine protein	0.004	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.004	0.0139	0.0139
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	myeloid:lymphoid or mixed lineage leukemia	0.004	0.0139	0.0139
Leishmania major	hypothetical protein, conserved	0.0041	0.0148	0.0148
Brugia malayi	FAD binding domain containing protein	0.1568	1	1
Echinococcus multilocularis	MAGUK p55 subfamily	0.004	0.0139	0.0139
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0178	0.1034	0.1034
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.1568	1	1
Plasmodium falciparum	ferredoxin--NADP reductase	0.0178	0.1034	0.1034
Echinococcus multilocularis	amyloid beta A4 protein	0.004	0.0139	0.0139
Schistosoma mansoni	dishevelled	0.004	0.0139	0.0139
Echinococcus multilocularis	membrane associated guanylate kinase ww and pdz	0.004	0.0139	0.0139
Toxoplasma gondii	flavodoxin domain-containing protein	0.0778	0.4904	1
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Mycobacterium ulcerans	flavodoxin reductase Hmp	0.0178	0.1034	0.0899
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	syntrophin	0.004	0.0139	0.0139
Brugia malayi	Guanylate kinase family protein	0.004	0.0139	0.0139
Plasmodium vivax	flavodoxin domain containing protein	0.139	0.885	0.885
Loa Loa (eye worm)	syntrophin-1	0.004	0.0139	0.0139
Echinococcus granulosus	pdz domain containing protein	0.004	0.0139	0.0139
Brugia malayi	hypothetical protein	0.004	0.0139	0.0139
Echinococcus multilocularis	partitioning defective protein 6	0.004	0.0139	0.0139
Echinococcus granulosus	multiple pdz domain protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Brugia malayi	C2 domain containing protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0155	0.0155
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.004	0.0139	0.0139
Brugia malayi	Syntrophin-1	0.004	0.0139	0.0139
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Brugia malayi	flavodoxin family protein	0.06	0.3754	0.3754
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.022	0.022
Brugia malayi	PDZ domain	0.004	0.0139	0.0139
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0148	0.0148
Echinococcus multilocularis	syndecan binding protein (syntenin)	0.004	0.0139	0.0139
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0178	0.1034	0.1034
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.1568	1	1
Echinococcus granulosus	3'partial\|membrane associated guanylate kinase ww and pdz	0.004	0.0139	0.0139
Schistosoma mansoni	regulator of G protein signaling	0.004	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.004	0.0139	0.0139
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.004	0.0139	0.0139
Leishmania major	cytochrome-b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.1568	1	1
Treponema pallidum	flavodoxin	0.06	0.3754	1
Loa Loa (eye worm)	PAR-6 protein	0.004	0.0139	0.0139
Trypanosoma cruzi	p450 reductase, putative	0.0178	0.1034	0.1034
Echinococcus granulosus	MAGUK p55 subfamily	0.004	0.0139	0.0139
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.004	0.0139	0.0139
Echinococcus multilocularis	55 kDa erythrocyte membrane protein	0.004	0.0139	0.0139
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0178	0.1034	0.1034
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.06	0.3754	0.366
Echinococcus granulosus	PRKCA binding protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0148	0.0148
Entamoeba histolytica	type A flavoprotein, putative	0.06	0.3754	1
Brugia malayi	MH2 domain containing protein	0.0144	0.0814	0.0814
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	cell polarity protein	0.004	0.0139	0.0139
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0178	0.1034	0.1034
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0178	0.1034	0.1034
Brugia malayi	Hypothetical 13.5 kDa protein C45G9.7 in chromosome III	0.004	0.0139	0.0139
Brugia malayi	hypothetical protein	0.004	0.0139	0.0139
Echinococcus multilocularis	PDZ domain containing protein GIPC3	0.004	0.0139	0.0139
Echinococcus multilocularis	pdz domain containing protein	0.004	0.0139	0.0139
Schistosoma mansoni	multiple pdz domain protein	0.004	0.0139	0.0139
Echinococcus granulosus	cytochrome b5 reductase 4	0.0178	0.1034	0.1034
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	hypothetical protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	PDZ-domain-containing protein scribble	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	pdz domain containing protein	0.004	0.0139	0.0139
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.1568	1	1
Leishmania major	oxidoreductase-like protein	0.0178	0.1034	0.1034
Echinococcus granulosus	disks large 1	0.004	0.0139	0.0139
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.0155	0.0155
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.0155	0.0007
Brugia malayi	Shank2E	0.004	0.0139	0.0139
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0148	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.022	0.022
Schistosoma mansoni	tight junction protein	0.004	0.0139	0.0139
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.004	0.0139	0.0139
Echinococcus multilocularis	Partitioning defective 3 protein B	0.004	0.0139	0.0139
Brugia malayi	beta-lactamase	0.0041	0.0148	0.0148
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Brugia malayi	Peripheral plasma membrane protein CASK	0.004	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Schistosoma mansoni	cytochrome B5	0.0178	0.1034	0.1034
Leishmania major	cytochrome-b5 reductase, putative	0.0178	0.1034	0.1034
Schistosoma mansoni	maguk P55 subfamily member 35	0.004	0.0139	0.0139
Schistosoma mansoni	ATP-dependent RNA Helicase	0.004	0.0139	0.0139
Mycobacterium ulcerans	electron transfer protein FdxB	0.0178	0.1034	0.0899
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.06	0.3754	0.3754
Loa Loa (eye worm)	hypothetical protein	0.004	0.0139	0.0139
Loa Loa (eye worm)	flavodoxin family protein	0.06	0.3754	0.3754
Trichomonas vaginalis	sulfite reductase, putative	0.1568	1	1
Echinococcus multilocularis	disks large 3	0.004	0.0139	0.0139
Schistosoma mansoni	sh3 and multiple ankyrin repeat domains protein 12 (shank12)	0.004	0.0139	0.0139
Echinococcus multilocularis	disks large 1	0.004	0.0139	0.0139

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	4.4668 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1900165

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1536572