TDR Targets

Basic information

Technical information

TDR Targets ID: 1536578
Name: N-cyclopentyl-2-[[2-[(4-fluorophenyl)sulfonyl amino]acetyl]-(oxolan-2-ylmethyl)amino]pentan amide
MW: 483.597 | Formula: C23H34FN3O5S
H donors: 2 H acceptors: 4 LogP: 2.82 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(N(C(=O)CNS(=O)(=O)c1ccc(cc1)F)CC1CCCO1)C(=O)NC1CCCC1
InChi: 1S/C23H34FN3O5S/c1-2-6-21(23(29)26-18-7-3-4-8-18)27(16-19-9-5-14-32-19)22(28)15-25-33(30,31)20-12-10-17(24)11-13-20/h10-13,18-19,21,25H,2-9,14-16H2,1H3,(H,26,29)
InChiKey: IQNCKRUHUUESRM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclopentyl-2-[[2-[(4-fluorophenyl)sulfonylamino]acetyl]-(tetrahydrofuran-2-ylmethyl)amino]pentanamide
N-cyclopentyl-2-[[2-[(4-fluorophenyl)sulfonylamino]-1-oxoethyl]-(2-tetrahydrofuranylmethyl)amino]pentanamide
N-cyclopentyl-2-[[2-[(4-fluorophenyl)sulfonylamino]acetyl]-(tetrahydrofurfuryl)amino]valeramide
N-cyclopentyl-2-[2-[(4-fluorophenyl)sulfonylamino]ethanoyl-(oxolan-2-ylmethyl)amino]pentanamide
ASN 05455789

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei	phosphoglycerate kinase	Starlite/ChEMBL	No references
Trypanosoma brucei gambiense	phosphoglycerate kinase, putative		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania infantum	phosphoglycerate kinase C, glycosomal	Get druggable targets OG5_126776	All targets in OG5_126776
Plasmodium berghei	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	Get druggable targets OG5_126776	All targets in OG5_126776
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	Get druggable targets OG5_126776	All targets in OG5_126776
Toxoplasma gondii	phosphoglycerate kinase PGKI	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma brucei	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Cryptosporidium parvum	phosphoglycerate kinase 1	Get druggable targets OG5_126776	All targets in OG5_126776
Plasmodium yoelii	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Brugia malayi	Phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Plasmodium falciparum	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma congolense	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania major	phosphoglycerate kinase B, cytosolic	Get druggable targets OG5_126776	All targets in OG5_126776
Theileria parva	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Plasmodium vivax	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Neospora caninum	hypothetical protein	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania braziliensis	PGKC, phosphoglycerate kinase C	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania donovani	phosphoglycerate kinase C, glycosomal	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma brucei gambiense	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Neospora caninum	Phosphoglycerate kinase (EC 2.7.2.3), related	Get druggable targets OG5_126776	All targets in OG5_126776
Plasmodium knowlesi	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma cruzi	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma brucei	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania mexicana	phosphoglycerate kinase C, glycosomal	Get druggable targets OG5_126776	All targets in OG5_126776
Chlamydia trachomatis	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma congolense	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania major	phosphoglycerate kinase C, glycosomal	Get druggable targets OG5_126776	All targets in OG5_126776
Entamoeba histolytica	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Trichomonas vaginalis	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma congolense	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma cruzi	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Echinococcus multilocularis	phosphoglycerate kinase 1	Get druggable targets OG5_126776	All targets in OG5_126776
Schistosoma mansoni	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania infantum	phosphoglycerate kinase B, cytosolic	Get druggable targets OG5_126776	All targets in OG5_126776
Trichomonas vaginalis	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Toxoplasma gondii	phosphoglycerate kinase PGKII	Get druggable targets OG5_126776	All targets in OG5_126776
Giardia lamblia	Phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Trypanosoma brucei gambiense	phosphoglycerate kinase, putative	Get druggable targets OG5_126776	All targets in OG5_126776
Schistosoma mansoni	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Mycobacterium ulcerans	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Candida albicans	3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W)	Get druggable targets OG5_126776	All targets in OG5_126776
Treponema pallidum	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Echinococcus granulosus	phosphoglycerate kinase 1	Get druggable targets OG5_126776	All targets in OG5_126776
Babesia bovis	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776
Candida albicans	3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W)	Get druggable targets OG5_126776	All targets in OG5_126776
Leishmania mexicana	phosphoglycerate kinase B, cytosolic	Get druggable targets OG5_126776	All targets in OG5_126776
Cryptosporidium hominis	phosphoglycerate kinase	Get druggable targets OG5_126776	All targets in OG5_126776

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.1625	1	1
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.0043	0.0085	0.0085
Giardia lamblia	Nitric oxide synthase, inducible	0.144	0.8842	1
Brugia malayi	Phosphoglycerate kinase	0.0075	0.0287	0.0287
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	cell polarity protein leucine rich repeat	0.0043	0.0085	0.0085
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	beta 1 syntrophin	0.0043	0.0085	0.0085
Echinococcus multilocularis	multiple pdz domain protein	0.0043	0.0085	0.0085
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.0043	0.0085	0.0085
Trypanosoma brucei	oxidoreductase-protein, putative	0.0185	0.0972	0.0972
Echinococcus multilocularis	disks large 1	0.0043	0.0085	0.0085
Schistosoma mansoni	cytochrome B5	0.0185	0.0972	0.0972
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.1625	1	1
Brugia malayi	diaphorase	0.0185	0.0972	0.0972
Echinococcus granulosus	cytochrome b5 reductase 4	0.0185	0.0972	0.0972
Echinococcus granulosus	syndecan binding protein syntenin	0.0043	0.0085	0.0085
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.1625	1	1
Schistosoma mansoni	afadin (af-6 protein)	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0185	0.0972	0.0972
Schistosoma mansoni	discs large	0.0043	0.0085	0.0085
Trypanosoma cruzi	p450 reductase, putative	0.1625	1	1
Leishmania major	reductase, putative	0.0185	0.0972	0.0705
Echinococcus multilocularis	MAGUK p55 subfamily	0.0043	0.0085	0.0085
Echinococcus granulosus	cytochrome b5 reductase 4	0.0185	0.0972	0.0972
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0185	0.0972	0.0972
Schistosoma mansoni	amyloid beta A4 protein related	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	snurportin 1	0.0317	0.1803	0.1803
Schistosoma mansoni	MAGUK homolog	0.0043	0.0085	0.0085
Leishmania major	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Brugia malayi	cell junction protein LIN-7	0.0043	0.0085	0.0085
Loa Loa (eye worm)	diaphorase	0.0185	0.0972	0.0972
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.1625	1	1
Trichomonas vaginalis	sulfite reductase, putative	0.1625	1	1
Echinococcus granulosus	partitioning defective 3	0.0043	0.0085	0.0085
Echinococcus multilocularis	MAGUK p55 subfamily	0.0043	0.0085	0.0085
Brugia malayi	PDZ domain	0.0043	0.0085	0.0085
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Treponema pallidum	phosphoglycerate kinase	0.0206	0.1102	0.0476
Brugia malayi	C2 domain containing protein	0.0043	0.0085	0.0085
Brugia malayi	PDZ domain containing protein	0.0043	0.0085	0.0085
Mycobacterium ulcerans	phosphoglycerate kinase	0.0206	0.1102	0.0144
Echinococcus multilocularis	microtubule associated serine:threonine protein	0.0043	0.0085	0.0085
Brugia malayi	Hypothetical 13.5 kDa protein C45G9.7 in chromosome III	0.0043	0.0085	0.0085
Brugia malayi	Partitioning defective-6 homolog alpha	0.0043	0.0085	0.0085
Echinococcus multilocularis	membrane associated guanylate kinase ww and pdz	0.0043	0.0085	0.0085
Schistosoma mansoni	maguk P55 subfamily member 26	0.0043	0.0085	0.0085
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0622	0.371	0.371
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.1625	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	pdz domain containing protein	0.0043	0.0085	0.0085
Leishmania major	nitrate reductase, putative	0.0185	0.0972	0.0705
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0109	0.0109
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0185	0.0972	0.0972
Brugia malayi	jmjC domain containing protein	0.0061	0.0194	0.0194
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.0043	0.0085	0.0085
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.1003	0.6104	0.6104
Loa Loa (eye worm)	PAR-6 protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	partitioning defective 3	0.0043	0.0085	0.0085
Schistosoma mansoni	dishevelled	0.0043	0.0085	0.0085
Schistosoma mansoni	pdz and lim domain protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.0194	0.0194
Brugia malayi	Protein-tyrosine phosphatase 1	0.0043	0.0085	0.0085
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0043	0.0085	0.0085
Schistosoma mansoni	leucine-rich repeat protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Leishmania major	oxidoreductase-like protein	0.0185	0.0972	0.0705
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0185	0.0972	0.0705
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0043	0.0085	0.0085
Echinococcus granulosus	Microtubule-associated serine/threonine-protein kinase	0.0043	0.0085	0.0085
Brugia malayi	Guanylate kinase family protein	0.0043	0.0085	0.0085
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0194	0.0194
Brugia malayi	RasGEF domain containing protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.1803	0.1803
Loa Loa (eye worm)	cytochrome P450 family protein	0.0058	0.0175	0.0175
Echinococcus multilocularis	ligand of numb protein x 2	0.0043	0.0085	0.0085
Echinococcus granulosus	pdz domain containing protein	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Brugia malayi	microtubule-associated serine/threonine protein kinase 2 (MAST2)	0.0043	0.0085	0.0085
Schistosoma mansoni	MAGUK homolog	0.0043	0.0085	0.0085
Echinococcus multilocularis	Partitioning defective 3 protein B	0.0043	0.0085	0.0085
Echinococcus multilocularis	protein piccolo	0.0043	0.0085	0.0085
Echinococcus multilocularis	multiple pdz domain protein	0.0043	0.0085	0.0085
Brugia malayi	9ORF binding protein 1	0.0043	0.0085	0.0085
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.1625	1	1
Echinococcus granulosus	PRKCA binding protein	0.0043	0.0085	0.0085
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.0043	0.0085	0.0085
Plasmodium falciparum	nitric oxide synthase, putative	0.1625	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	membrane associated guanylate kinase, WW and PDZ	0.0043	0.0085	0.0085
Plasmodium falciparum	phosphoglycerate kinase	0.0206	0.1102	0.1102
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.0194	0.0194
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	neurabin 1	0.0043	0.0085	0.0085
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0109	0.0109
Echinococcus multilocularis	MAGUK p55 subfamily	0.0043	0.0085	0.0085
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.1625	1	1
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0185	0.0972	0.0705
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0206	0.1102	0.0839
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Echinococcus multilocularis	55 kDa erythrocyte membrane protein	0.0043	0.0085	0.0085
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.144	0.8842	0.8699
Echinococcus multilocularis	protein lin 7 B	0.0043	0.0085	0.0085
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0206	0.1102	0.2264
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0109	0.0109
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Plasmodium vivax	flavodoxin domain containing protein	0.144	0.8842	0.8842
Leishmania major	hypothetical protein, conserved	0.0622	0.371	0.3525
Entamoeba histolytica	type A flavoprotein, putative	0.0622	0.371	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0185	0.0972	0.1996
Echinococcus granulosus	disks large 1	0.0043	0.0085	0.0085
Brugia malayi	PDZ-domain protein scribble	0.0043	0.0085	0.0085
Echinococcus multilocularis	Rho GTPase activating protein 21	0.0043	0.0085	0.0085
Echinococcus multilocularis	partitioning defective 3	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0109	0.0109
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0622	0.371	0.3525
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	disks large 3	0.0043	0.0085	0.0085
Echinococcus multilocularis	segment polarity protein dishevelled	0.0043	0.0085	0.0085
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0185	0.0972	0.0972
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Brugia malayi	Patj homolog	0.0043	0.0085	0.0085
Schistosoma mansoni	leucine-rich repeat protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0185	0.0972	0.0972
Plasmodium falciparum	ferredoxin--NADP reductase	0.0185	0.0972	0.0972
Giardia lamblia	Hypothetical protein	0.144	0.8842	1
Brugia malayi	protein kinase C-binding protein PICK1	0.0043	0.0085	0.0085
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0622	0.371	0.371
Brugia malayi	Guanylate kinase family protein	0.0043	0.0085	0.0085
Brugia malayi	flavodoxin family protein	0.0622	0.371	0.371
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0206	0.1102	0.1102
Entamoeba histolytica	type A flavoprotein, putative	0.0622	0.371	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Schistosoma mansoni	ATP-dependent RNA Helicase	0.0043	0.0085	0.0085
Schistosoma mansoni	PDZ domain protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	Na(+):H(+) exchange regulatory cofactor NHE RF2	0.0043	0.0085	0.0085
Schistosoma mansoni	multiple pdz domain protein	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	guanylate kinase	0.0043	0.0085	0.0085
Echinococcus granulosus	Partitioning defective 3 protein B	0.0043	0.0085	0.0085
Schistosoma mansoni	maguk P55 subfamily member 35	0.0043	0.0085	0.0085
Schistosoma mansoni	protein kinase C alpha binding protein	0.0043	0.0085	0.0085
Echinococcus granulosus	55 kDa erythrocyte membrane protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Brugia malayi	Ferm domain	0.0043	0.0085	0.0085
Echinococcus granulosus	membrane associated guanylate kinase, WW and PDZ	0.0043	0.0085	0.0085
Brugia malayi	PDZ domain	0.0043	0.0085	0.0085
Toxoplasma gondii	flavodoxin domain-containing protein	0.0806	0.4868	1
Schistosoma mansoni	cell polarity protein	0.0043	0.0085	0.0085
Leishmania major	cytochrome-b5 reductase, putative	0.0185	0.0972	0.0705
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0206	0.1102	0.0839
Echinococcus granulosus	lysine specific demethylase 5A	0.0061	0.0194	0.0194
Schistosoma mansoni	syntenin	0.0043	0.0085	0.0085
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.1625	1	1
Brugia malayi	jmjC domain containing protein	0.0061	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0043	0.0085	0.0085
Entamoeba histolytica	type A flavoprotein, putative	0.0622	0.371	1
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.0043	0.0085	0.0085
Schistosoma mansoni	lin-7-like proteins	0.0043	0.0085	0.0085
Brugia malayi	Phosphoglycerate kinase	0.0206	0.1102	0.1102
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0109	0.0109
Toxoplasma gondii	flavodoxin domain-containing protein	0.0806	0.4868	1
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.0043	0.0085	0.0085
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.1625	1	1
Trypanosoma brucei	phosphoglycerate kinase	0.0075	0.0287	0.0287
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0185	0.0972	0.0972
Brugia malayi	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	segment polarity protein dishevelled	0.0043	0.0085	0.0085
Plasmodium vivax	phosphoglycerate kinase, putative	0.0206	0.1102	0.1102
Brugia malayi	gopc protein	0.0043	0.0085	0.0085
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0075	0.0287	0.0287
Echinococcus granulosus	multiple pdz domain protein	0.0043	0.0085	0.0085
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0194	0.0194
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0622	0.371	0.3525
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Brugia malayi	gamma-syntrophin-like protein SYN2	0.0043	0.0085	0.0085
Brugia malayi	rho guanine nucleotide exchange factor 12	0.0043	0.0085	0.0085
Chlamydia trachomatis	sulfite reductase	0.1003	0.6104	1
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.0043	0.0085	0.0085
Schistosoma mansoni	cell polarity protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	multiple pdz domain protein	0.0043	0.0085	0.0085
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.0043	0.0085	0.0085
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0622	0.371	0.2931
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0109	0.0109
Echinococcus multilocularis	myeloid:lymphoid or mixed lineage leukemia	0.0043	0.0085	0.0085
Brugia malayi	PDZ domain containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.1625	1	1
Brugia malayi	Abnormal embryonic partitioning of cytoplasm protein 3	0.0043	0.0085	0.0085
Trypanosoma cruzi	p450 reductase, putative	0.0185	0.0972	0.0705
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0043	0.0085	0.0085
Loa Loa (eye worm)	PDZ-domain-containing protein scribble	0.0043	0.0085	0.0085
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0109	0.0109
Schistosoma mansoni	hypothetical protein	0.0317	0.1803	0.1803
Loa Loa (eye worm)	syntrophin-1	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	nitrate reductase, putative	0.0185	0.0972	0.0705
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0185	0.0972	0.1996
Schistosoma mansoni	multiple pdz domain protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	partitioning defective protein 6	0.0043	0.0085	0.0085
Trypanosoma brucei	nitrate reductase, putative	0.0185	0.0972	0.0972
Brugia malayi	Synapse defective protein 1	0.0043	0.0085	0.0085
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0043	0.0085	0.0085
Echinococcus granulosus	MAGUK p55 subfamily	0.0043	0.0085	0.0085
Entamoeba histolytica	type A flavoprotein, putative	0.0622	0.371	1
Brugia malayi	hypothetical protein	0.0043	0.0085	0.0085
Brugia malayi	PX domain containing protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.0043	0.0085	0.0085
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0185	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	sh3 and multiple ankyrin repeat domains protein 12 (shank12)	0.0043	0.0085	0.0085
Leishmania major	p450 reductase, putative	0.1625	1	1
Brugia malayi	syntenin	0.0043	0.0085	0.0085
Loa Loa (eye worm)	cell junction protein LIN-7	0.0043	0.0085	0.0085
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Echinococcus multilocularis	rho guanine nucleotide exchange factor 12	0.0043	0.0085	0.0085
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0972
Loa Loa (eye worm)	DIX domain-containing protein	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0043	0.0085	0.0085
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.1625	1	1
Echinococcus granulosus	beta 1 syntrophin	0.0043	0.0085	0.0085
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0622	0.371	0.3525
Schistosoma mansoni	sap-97	0.0043	0.0085	0.0085
Brugia malayi	PDZ domain containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	ligand of numb protein x 2	0.0043	0.0085	0.0085
Echinococcus multilocularis		0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Brugia malayi	Cytochrome P450 family protein	0.0058	0.0175	0.0175
Onchocerca volvulus		0.0185	0.0972	1
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.1625	1	1
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0622	0.371	0.2931
Echinococcus granulosus	rho guanine nucleotide exchange factor 12	0.0043	0.0085	0.0085
Echinococcus granulosus	cell polarity protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	reductase, putative	0.0185	0.0972	0.0705
Echinococcus multilocularis	pdz domain containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	MAGUK p55 subfamily	0.0043	0.0085	0.0085
Echinococcus granulosus	Rho GTPase activating protein 21	0.0043	0.0085	0.0085
Echinococcus multilocularis	neurabin 1	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	Na:H exchange regulatory cofactor NHE RF2	0.0043	0.0085	0.0085
Loa Loa (eye worm)	peripheral plasma membrane protein CASK	0.0043	0.0085	0.0085
Schistosoma mansoni	cell polarity protein	0.0043	0.0085	0.0085
Echinococcus granulosus	pdz domain containing protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	amyloid beta A4 protein	0.0043	0.0085	0.0085
Schistosoma mansoni	multiple pdz domain protein	0.0043	0.0085	0.0085
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	MAGUK p55 subfamily	0.0043	0.0085	0.0085
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0185	0.0972	0.0705
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0109	0.0109
Schistosoma mansoni	phosphoglycerate kinase	0.0206	0.1102	0.1102
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	diflavin oxidoreductase	0.0806	0.4868	0.4868
Echinococcus multilocularis	snurportin 1	0.0317	0.1803	0.1803
Echinococcus granulosus	pdz domain containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	phosphoglycerate kinase 1	0.0206	0.1102	0.1102
Schistosoma mansoni	regulator of G protein signaling	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1102	0.1102
Echinococcus granulosus	3'partial\|membrane associated guanylate kinase ww and pdz	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0185	0.0972	0.0705
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0206	0.1102	0.0839
Loa Loa (eye worm)	gopc protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.1625	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.0043	0.0085	0.0085
Schistosoma mansoni	multiple pdz domain protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	PDZ domain-containing protein	0.0043	0.0085	0.0085
Brugia malayi	interleukin-16	0.0043	0.0085	0.0085
Schistosoma mansoni	pdz domain containing protein	0.0043	0.0085	0.0085
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0185	0.0972	0.0972
Echinococcus granulosus	protein lin 7 B	0.0043	0.0085	0.0085
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0206	0.1102	1
Echinococcus granulosus	methionine synthase reductase	0.1003	0.6104	0.6104
Echinococcus granulosus	amyloid beta A4 protein	0.0043	0.0085	0.0085
Trypanosoma brucei	phosphoglycerate kinase	0.0206	0.1102	0.1102
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0622	0.371	0.2931
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0819	0.4946	0.4946
Brugia malayi	FAD binding domain containing protein	0.1625	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	myeloid:lymphoid or mixed lineage leukemia	0.0043	0.0085	0.0085
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0622	0.371	0.2931
Schistosoma mansoni	discs lost-related	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	guanylate kinase	0.0043	0.0085	0.0085
Brugia malayi	Peripheral plasma membrane protein CASK	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	cell polarity protein	0.0043	0.0085	0.0085
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0043	0.0085	0.0085
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0206	0.1102	0.0839
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0206	0.1102	0.5
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0185	0.0972	0.0705
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	methionine synthase reductase	0.1003	0.6104	0.6104
Brugia malayi	DIX domain containing protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.1625	1	1
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0185	0.0972	0.1474
Loa Loa (eye worm)	9ORF binding protein 1	0.0043	0.0085	0.0085
Echinococcus multilocularis	peripheral plasma membrane protein CASK	0.0043	0.0085	0.0085
Echinococcus multilocularis	PDZ domain containing protein GIPC3	0.0043	0.0085	0.0085
Schistosoma mansoni	multiple pdz domain protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.0194	0.0194
Echinococcus granulosus	segment polarity protein dishevelled	0.0043	0.0085	0.0085
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.1625	1	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0972
Echinococcus multilocularis	segment polarity protein dishevelled	0.0043	0.0085	0.0085
Echinococcus granulosus	partitioning defective 3	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0043	0.0085	0.0085
Brugia malayi	PDZ domain containing protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Treponema pallidum	flavodoxin	0.0622	0.371	1
Echinococcus multilocularis	pdz domain containing protein	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Plasmodium vivax	hypothetical protein, conserved	0.0622	0.371	0.371
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0972
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0185	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0043	0.0085	0.0085
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Echinococcus multilocularis	tight junction protein ZO 3	0.0043	0.0085	0.0085
Trypanosoma brucei	phosphoglycerate kinase	0.0206	0.1102	0.1102
Schistosoma mansoni	Patj homolog	0.0043	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0185	0.0972	0.0972
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0185	0.0972	0.0705
Echinococcus granulosus	tight junction protein ZO 3	0.0043	0.0085	0.0085
Echinococcus multilocularis	pdz domain containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.0043	0.0085	0.0085
Brugia malayi	FAD binding domain containing protein	0.1003	0.6104	0.6104
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0206	0.1102	0.2264
Schistosoma mansoni	phosphoglycerate kinase	0.0206	0.1102	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0194	0.0194
Schistosoma mansoni	tight junction protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0185	0.0972	0.0972
Echinococcus granulosus	peripheral plasma membrane protein CASK	0.0043	0.0085	0.0085
Loa Loa (eye worm)	FAD binding domain-containing protein	0.1625	1	1
Brugia malayi	RNA, U transporter 1	0.0085	0.0344	0.0344
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0185	0.0972	0.0705
Schistosoma mansoni	syntrophin	0.0043	0.0085	0.0085
Echinococcus multilocularis	PRKCA binding protein	0.0043	0.0085	0.0085
Entamoeba histolytica	type A flavoprotein, putative	0.0622	0.371	1
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.0043	0.0085	0.0085
Schistosoma mansoni	lim domain	0.0043	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0043	0.0085	0.0085
Echinococcus granulosus	pdz domain containing protein	0.0043	0.0085	0.0085
Giardia lamblia	Phosphoglycerate kinase	0.0206	0.1102	0.0165
Loa Loa (eye worm)	X11 protein	0.0043	0.0085	0.0085
Brugia malayi	Shank2E	0.0043	0.0085	0.0085
Echinococcus granulosus	multiple pdz domain protein	0.0043	0.0085	0.0085
Leishmania major	cytochrome P450 reductase, putative	0.144	0.8842	0.8808
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0206	0.1102	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	FAD binding domain-containing protein	0.1003	0.6104	0.6104
Chlamydia trachomatis	phosphoglycerate kinase	0.0206	0.1102	0.169
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0085	0.0085
Schistosoma mansoni	cytochrome P450 reductase	0.1625	1	1
Echinococcus granulosus	disks large 3	0.0043	0.0085	0.0085
Brugia malayi	Neurabin protein 1	0.0043	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	flavodoxin family protein	0.0622	0.371	0.371
Echinococcus granulosus	multiple pdz domain protein	0.0043	0.0085	0.0085
Loa Loa (eye worm)	PX domain-containing protein	0.0043	0.0085	0.0085
Echinococcus granulosus	glutamate receptor interacting protein 1	0.0043	0.0085	0.0085
Brugia malayi	Syntrophin-1	0.0043	0.0085	0.0085
Schistosoma mansoni	dishevelled	0.0043	0.0085	0.0085
Leishmania major	cytochrome-b5 reductase, putative	0.0185	0.0972	0.0705
Schistosoma mansoni	pdz domain containing protein	0.0043	0.0085	0.0085
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0109	0.0109
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0622	0.371	0.371
Echinococcus multilocularis	syndecan binding protein (syntenin)	0.0043	0.0085	0.0085

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1902200

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1536578