Detailed information for compound 1536588

Basic information

Technical information
  • TDR Targets ID: 1536588
  • Name: 5-fluoro-4-methoxy-1-(5-oxo-2H-furan-2-yl)pyr imidin-2-one
  • MW: 226.161 | Formula: C9H7FN2O4
  • H donors: 0 H acceptors: 2 LogP: 0.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc(=O)n(cc1F)C1OC(=O)C=C1
  • InChi: 1S/C9H7FN2O4/c1-15-8-5(10)4-12(9(14)11-8)6-2-3-7(13)16-6/h2-4,6H,1H3
  • InChiKey: SOMYTVQCIUWOSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-fluoro-4-methoxy-1-(5-oxo-2H-furan-2-yl)-2-pyrimidinone
  • 5-fluoro-1-(5-keto-2H-furan-2-yl)-4-methoxy-pyrimidin-2-one
  • 2(1H)-Pyrimidinone, 1-(2,5-dihydro-5-oxo-2-furanyl)-5-fluoro-4-methoxy-
  • NSC315844

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Peripheral plasma membrane protein CASK 0.004 0.0062 0.0062
Leishmania major oxidoreductase-like protein 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Mycobacterium tuberculosis Probable oxidoreductase 0.0178 0.0962 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0161 0.01
Echinococcus multilocularis methionine synthase reductase 0.0969 0.6099 0.6075
Entamoeba histolytica type A flavoprotein, putative 0.06 0.3703 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Schistosoma mansoni cytochrome P450 reductase 0.157 1 1
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.157 1 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0779 0.4862 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.157 1 1
Loa Loa (eye worm) X11 protein 0.004 0.0062 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0161 0.01
Brugia malayi MH2 domain containing protein 0.0144 0.0739 0.0739
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0161 0.01
Loa Loa (eye worm) FAD binding domain-containing protein 0.0969 0.6099 0.6099
Leishmania major nitrate reductase, putative 0.0178 0.0962 0.0962
Schistosoma mansoni cytochrome B5 0.0178 0.0962 0.0905
Leishmania major NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.01
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0178 0.0962 0.0905
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.004 0.0062 0.0062
Brugia malayi hypothetical protein 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.157 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi PDZ domain 0.004 0.0062 0.0062
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.06 0.3703 0.3703
Brugia malayi Guanylate kinase family protein 0.004 0.0062 0.0062
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.157 1 1
Brugia malayi cell junction protein LIN-7 0.004 0.0062 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0161 0.0161
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0178 0.0962 0.0962
Brugia malayi protein kinase C-binding protein PICK1 0.004 0.0062 0.0062
Brugia malayi gopc protein 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0178 0.0962 0.1978
Onchocerca volvulus 0.0178 0.0962 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0178 0.0962 0.5
Trypanosoma cruzi nitrate reductase, putative 0.0178 0.0962 0.0962
Leishmania major p450 reductase, putative 0.157 1 1
Chlamydia trachomatis sulfite reductase 0.0969 0.6099 1
Loa Loa (eye worm) syntrophin-1 0.004 0.0062 0.0062
Trypanosoma cruzi oxidoreductase-protein, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Mycobacterium tuberculosis Possible oxygenase 0.0178 0.0962 0.5
Giardia lamblia Hypothetical protein 0.1391 0.8841 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Leishmania major cytochrome P450 reductase, putative 0.1391 0.8841 0.8841
Loa Loa (eye worm) PX domain-containing protein 0.004 0.0062 0.0062
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0178 0.0962 0.149
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi PDZ domain containing protein 0.004 0.0062 0.0062
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.06 0.3703 0.3703
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi Patj homolog 0.004 0.0062 0.0062
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.157 1 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Leishmania major NADH-dependent fumarate reductase-like protein 0.0178 0.0962 0.0962
Brugia malayi gamma-syntrophin-like protein SYN2 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trichomonas vaginalis sulfite reductase, putative 0.157 1 1
Brugia malayi PX domain containing protein 0.004 0.0062 0.0062
Trypanosoma brucei NADH-dependent fumarate reductase 0.0178 0.0962 0.0962
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0178 0.0962 0.0962
Leishmania major NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Echinococcus granulosus methionine synthase reductase 0.0969 0.6099 0.6075
Brugia malayi hypothetical protein 0.004 0.0062 0.0062
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.157 1 1
Brugia malayi Partitioning defective-6 homolog alpha 0.004 0.0062 0.0062
Brugia malayi PDZ domain containing protein 0.004 0.0062 0.0062
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.06 0.3703 0.3703
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0161 0.0161
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0969 0.6099 0.6075
Loa Loa (eye worm) DIX domain-containing protein 0.004 0.0062 0.0062
Mycobacterium tuberculosis Probable monooxygenase 0.0178 0.0962 0.5
Trypanosoma brucei nitrate reductase, putative 0.0178 0.0962 0.0962
Brugia malayi hypothetical protein 0.004 0.0062 0.0062
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Brugia malayi hypothetical protein 0.004 0.0062 0.0062
Plasmodium falciparum ferredoxin--NADP reductase 0.0178 0.0962 0.0962
Entamoeba histolytica type A flavoprotein, putative 0.06 0.3703 0.5
Toxoplasma gondii flavodoxin domain-containing protein 0.0779 0.4862 1
Trypanosoma cruzi p450 reductase, putative 0.157 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.157 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0161 0.01
Brugia malayi syntenin 0.004 0.0062 0.0062
Giardia lamblia Nitric oxide synthase, inducible 0.1391 0.8841 1
Brugia malayi hypothetical protein 0.004 0.0062 0.0062
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0178 0.0962 0.1978
Brugia malayi rho guanine nucleotide exchange factor 12 0.004 0.0062 0.0062
Schistosoma mansoni NADPH flavin oxidoreductase 0.0791 0.494 0.4908
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Brugia malayi DIX domain containing protein 0.004 0.0062 0.0062
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.004 0.0062 0.0062
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Echinococcus granulosus cytochrome b5 reductase 4 0.0178 0.0962 0.0905
Brugia malayi Neurabin protein 1 0.004 0.0062 0.0062
Loa Loa (eye worm) PAR-6 protein 0.004 0.0062 0.0062
Loa Loa (eye worm) guanylate kinase 0.004 0.0062 0.0062
Loa Loa (eye worm) PDZ domain-containing protein 0.004 0.0062 0.0062
Plasmodium vivax flavodoxin domain containing protein 0.1391 0.8841 0.8841
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.1391 0.8841 0.8159
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.004 0.0062 0.0062
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Entamoeba histolytica type A flavoprotein, putative 0.06 0.3703 0.5
Brugia malayi interleukin-16 0.004 0.0062 0.0062
Treponema pallidum flavodoxin 0.06 0.3703 1
Brugia malayi hypothetical protein 0.004 0.0062 0.0062
Loa Loa (eye worm) guanylate kinase 0.004 0.0062 0.0062
Loa Loa (eye worm) 9ORF binding protein 1 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.157 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0178 0.0962 0.0962
Leishmania major cytochrome-b5 reductase, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0739 0.0739
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.157 1 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.157 1 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Brugia malayi 9ORF binding protein 1 0.004 0.0062 0.0062
Brugia malayi Guanylate kinase family protein 0.004 0.0062 0.0062
Trypanosoma brucei oxidoreductase-protein, putative 0.0178 0.0962 0.0962
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0178 0.0962 0.0905
Plasmodium vivax hypothetical protein, conserved 0.06 0.3703 0.3703
Trypanosoma cruzi cytochrome P450 reductase, putative 0.157 1 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.157 1 1
Loa Loa (eye worm) diaphorase 0.0178 0.0962 0.0962
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0178 0.0962 0.0962
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.06 0.3703 0.3703
Brugia malayi PDZ domain containing protein 0.004 0.0062 0.0062
Brugia malayi Ferm domain 0.004 0.0062 0.0062
Brugia malayi diaphorase 0.0178 0.0962 0.0962
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.157 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Loa Loa (eye worm) FAD binding domain-containing protein 0.157 1 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi Protein-tyrosine phosphatase 1 0.004 0.0062 0.0062
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Leishmania major hypothetical protein, conserved 0.06 0.3703 0.3703
Leishmania major NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Brugia malayi C2 domain containing protein 0.004 0.0062 0.0062
Plasmodium falciparum nitric oxide synthase, putative 0.157 1 1
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.004 0.0062 0.0062
Loa Loa (eye worm) cell junction protein LIN-7 0.004 0.0062 0.0062
Trypanosoma cruzi p450 reductase, putative 0.0178 0.0962 0.0962
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) gopc protein 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Brugia malayi Syntrophin-1 0.004 0.0062 0.0062
Brugia malayi Synapse defective protein 1 0.004 0.0062 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0739 0.0739
Brugia malayi PDZ-domain protein scribble 0.004 0.0062 0.0062
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0178 0.0962 0.0905
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Schistosoma mansoni diflavin oxidoreductase 0.0779 0.4862 0.483
Trypanosoma cruzi reductase, putative 0.0178 0.0962 0.0962
Leishmania major NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.004 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.01
Brugia malayi flavodoxin family protein 0.06 0.3703 0.3703
Brugia malayi PDZ domain 0.004 0.0062 0.0062
Echinococcus multilocularis cytochrome b5 reductase 4 0.0178 0.0962 0.0905
Entamoeba histolytica type A flavoprotein, putative 0.06 0.3703 0.5
Loa Loa (eye worm) RasGEF domain-containing protein 0.004 0.0062 0.0062
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Trypanosoma brucei NADH-dependent fumarate reductase 0.0178 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Echinococcus granulosus cytochrome b5 reductase 4 0.0178 0.0962 0.0905
Entamoeba histolytica type A flavoprotein, putative 0.06 0.3703 0.5
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0178 0.0962 0.0962
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.06 0.3703 0.3703
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0178 0.0962 0.0962
Leishmania major reductase, putative 0.0178 0.0962 0.0962
Leishmania major cytochrome-b5 reductase, putative 0.0178 0.0962 0.0962
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0178 0.0962 0.5
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0178 0.0962 0.0962
Brugia malayi FAD binding domain containing protein 0.157 1 1
Loa Loa (eye worm) flavodoxin family protein 0.06 0.3703 0.3703
Brugia malayi RasGEF domain containing protein 0.004 0.0062 0.0062
Echinococcus granulosus NADPH cytochrome P450 reductase 0.157 1 1
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.06 0.3703 0.3703
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Brugia malayi FAD binding domain containing protein 0.0969 0.6099 0.6099
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.01
Loa Loa (eye worm) hypothetical protein 0.004 0.0062 0.0062
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.157 1 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0178 0.0962 0.0962
Brugia malayi PDZ domain containing protein 0.004 0.0062 0.0062
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.004 0.0062 0.0062
Brugia malayi Shank2E 0.004 0.0062 0.0062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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