Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0125 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0125 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0125 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0125 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0125 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0125 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0125 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0125 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0125 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0125 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0125 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0125 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0125 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0125 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0125 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0077 | 0.2407 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0125 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0125 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0125 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0063 | 0.0151 | 0.0151 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0111 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0125 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0111 | 0.7743 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0125 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0077 | 0.2407 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.