Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1566 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1566 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1566 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0777 | 0 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1566 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1566 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0967 | 0.2407 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.1566 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1566 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1566 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1388 | 0.7743 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1566 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.1566 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0789 | 0.0151 | 0.0151 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0777 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1388 | 0.7743 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1566 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0967 | 0.2407 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1566 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1566 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1566 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1566 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1566 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.1566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1566 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1566 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1566 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1566 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1566 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.