Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4591 | 0.4591 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4591 | 0.4591 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.3848 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4467 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.