TDR Targets

Basic information

Technical information

TDR Targets ID: 1537111
Name: 4,6-di(phenyl)-2H-pyridazin-3-one
MW: 248.279 | Formula: C16H12N2O
H donors: 1 H acceptors: 3 LogP: 3.11 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1nnc(cc1c1ccccc1)c1ccccc1
InChi: 1S/C16H12N2O/c19-16-14(12-7-3-1-4-8-12)11-15(17-18-16)13-9-5-2-6-10-13/h1-11H,(H,18,19)
InChiKey: BTDANPVPCPUIPF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ST5431465
4,6-diphenylpyridazin-3(2H)-one
MLS001143393
SMR000473228
Oprea1_819115

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	trypanothione reductase	0.001	0.0021	0.1246
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0023	0.0102	0.0093
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0137	0.0785	0.6609
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0421	0.3544
Mycobacterium tuberculosis	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0157	0.09	0.0892
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0999
Schistosoma mansoni	aldehyde dehydrogenase	0.0013	0.0038	0.032
Echinococcus granulosus	BC026374 protein S09 family	0.0023	0.0102	0.0859
Schistosoma mansoni	acetylcholinesterase	0.0023	0.0102	0.0859
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0421	0.3544
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0102	0.0859
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0024	0.011	0.424
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0013	0.0038	0.032
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0009	0.0019	0.001
Toxoplasma gondii	aldehyde dehydrogenase	0.0013	0.0038	0.2465
Brugia malayi	Carboxylesterase family protein	0.0023	0.0102	0.13
Loa Loa (eye worm)	acetylcholinesterase 1	0.0137	0.0785	1
Brugia malayi	dihydrofolate reductase family protein	0.0009	0.0019	0.0236
Schistosoma mansoni	sodium/chloride dependent transporter	0.0032	0.0154	0.1298
Onchocerca volvulus		0.0032	0.0154	0.6041
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0023	0.0102	0.0859
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0421	0.3544
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0024	0.011	0.7057
Brugia malayi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0007	0.0003	0.0033
Chlamydia trachomatis	cysteine--tRNA ligase	0.0024	0.011	0.3026
Brugia malayi	TAR-binding protein	0.0076	0.0421	0.5363
Treponema pallidum	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0036	0.018	0.3333
Toxoplasma gondii	glycosyl transferase, group 4 family protein	0.0007	0.0003	0.0167
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0013	0.0038	0.032
Mycobacterium ulcerans	thymidylate synthase	0.0023	0.0099	0.0096
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0023	0.0102	0.0859
Mycobacterium ulcerans	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0157	0.09	0.0898
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0032	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0154	0.1963
Schistosoma mansoni	aldehyde dehydrogenase	0.0013	0.0038	0.032
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0009	0.0019	0.001
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0032	0.0154	0.1963
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0421	0.5363
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0025	0.0111	0.0102
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0024	0.011	0.0923
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.1678	1	1
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0007	0.0003	0.0022
Plasmodium falciparum	cysteine--tRNA ligase	0.0024	0.011	0.7057
Treponema pallidum	sodium- and chloride- dependent transporter	0.0032	0.0154	0.2118
Brugia malayi	hypothetical protein	0.0023	0.0102	0.13
Echinococcus multilocularis	para nitrobenzyl esterase	0.0023	0.0102	0.0859
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0023	0.0099	0.009
Echinococcus multilocularis	serotonin transporter	0.0032	0.0154	0.1298
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0011	0.0028	0.1662
Schistosoma mansoni	hypothetical protein	0.0205	0.1187	1
Echinococcus granulosus	geminin	0.0205	0.1187	1
Echinococcus granulosus	serotonin transporter	0.0032	0.0154	0.1298
Wolbachia endosymbiont of Brugia malayi	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0157	0.09	1
Loa Loa (eye worm)	glutathione reductase	0.001	0.0021	0.0274
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0102	0.13
Brugia malayi	Carboxylesterase family protein	0.0137	0.0785	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0033
Onchocerca volvulus		0.0023	0.0102	0.4001
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Plasmodium falciparum	cysteine--tRNA ligase	0.0024	0.011	0.7057
Mycobacterium tuberculosis	Probable oxidoreductase	0.0025	0.0111	0.0102
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0022	0.0096	0.0087
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.001	0.0021	0.0012
Loa Loa (eye worm)	thymidylate synthase	0.0023	0.0099	0.126
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0022	0.0096	0.0087
Echinococcus granulosus	dihydrofolate reductase	0.0009	0.0019	0.0156
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0023	0.0102	0.0093
Echinococcus multilocularis	UDP N acetylglucosamine dolichyl phosphate	0.0007	0.0003	0.0022
Brugia malayi	glutathione reductase	0.001	0.0021	0.0274
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0013	0.0038	0.0035
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	0.0036	0.018	0.0884
Treponema pallidum	phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY)	0.006	0.0319	1
Schistosoma mansoni	dihydrofolate reductase	0.0009	0.0019	0.0156
Echinococcus granulosus	para nitrobenzyl esterase	0.0023	0.0102	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0024	0.011	0.1397
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0024	0.011	0.0107
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0024	0.011	0.7057
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0024	0.011	0.7106
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0025	0.0111	0.0102
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.1678	1	1
Echinococcus multilocularis	acetylcholinesterase	0.0137	0.0785	0.6609
Loa Loa (eye worm)	carboxylesterase	0.0137	0.0785	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0421	0.5363
Echinococcus granulosus	leucyl tRNA synthetase	0.0024	0.011	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0154	0.1963
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0024	0.011	0.0923
Trypanosoma brucei	trypanothione reductase	0.001	0.0021	0.1246
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0354
Mycobacterium tuberculosis	Probable dehydrogenase	0.0022	0.0096	0.0087
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0421	0.5363
Brugia malayi	Thioredoxin reductase	0.001	0.0021	0.0274
Trichomonas vaginalis	spcc417.12 protein, putative	0.0023	0.0102	0.394
Schistosoma mansoni	hypothetical protein	0.0205	0.1187	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0421	0.3544
Trichomonas vaginalis	set domain proteins, putative	0.0049	0.0255	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Mycobacterium ulcerans	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0036	0.018	0.0177
Plasmodium vivax	thioredoxin reductase, putative	0.001	0.0021	0.1392
Echinococcus multilocularis	neuroligin	0.0023	0.0102	0.0859
Brugia malayi	Dihydrofolate reductase	0.0009	0.0019	0.0236
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0032	0.0154	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0013	0.0038	0.2337
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0024	0.011	0.7057
Brugia malayi	RNA binding protein	0.0076	0.0421	0.5363
Brugia malayi	Carboxylesterase family protein	0.0023	0.0102	0.13
Onchocerca volvulus		0.0023	0.0102	0.4001
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0032	0.0154	1
Onchocerca volvulus		0.0023	0.0102	0.4001
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Echinococcus granulosus	UDP N acetylglucosamine dolichyl phosphate	0.0007	0.0003	0.0022
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0007	0.0003	0.0022
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0102	0.13
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0024	0.011	0.7106
Mycobacterium ulcerans	carboxylesterase, LipT	0.0023	0.0102	0.0099
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0022	0.0096	0.0087
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0023	0.0102	0.0859
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0022	0.0096	0.0087
Plasmodium vivax	glutathione reductase, putative	0.001	0.0021	0.1392
Echinococcus multilocularis	dihydrofolate reductase	0.0009	0.0019	0.0156
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0023	0.0102	0.394
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0785	1
Brugia malayi	Carboxylesterase family protein	0.0023	0.0102	0.13
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0025	0.0111	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0024	0.011	0.7057
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0785	1
Echinococcus granulosus	thymidylate synthase	0.0023	0.0099	0.0833
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0024	0.011	0.1397
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0421	0.3544
Brugia malayi	thymidylate synthase	0.0023	0.0099	0.126
Mycobacterium tuberculosis	Probable reductase	0.0022	0.0096	0.0087
Echinococcus multilocularis	acetylcholinesterase	0.0137	0.0785	0.6609
Loa Loa (eye worm)	thioredoxin reductase	0.001	0.0021	0.0274
Giardia lamblia	Cysteinyl-tRNA synthetase	0.0024	0.011	1
Echinococcus multilocularis	thymidylate synthase	0.0023	0.0099	0.0833
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0032	0.0154	0.1963
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0421	0.3544
Echinococcus granulosus	acetylcholinesterase	0.0137	0.0785	0.6609
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0043	0.022	0.2798
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0024	0.011	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0032	0.0154	0.1298
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0102	0.0859
Loa Loa (eye worm)	norepinephrine transporter	0.0032	0.0154	0.1963
Echinococcus granulosus	carboxylesterase 5A	0.0137	0.0785	0.6609
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0023	0.0099	0.009
Schistosoma mansoni	BC026374 protein (S09 family)	0.0023	0.0102	0.0859
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0024	0.011	0.0923
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0421	0.3544
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0023	0.0102	0.0859
Plasmodium falciparum	glutathione reductase	0.001	0.0021	0.1246
Chlamydia trachomatis	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	0.0036	0.018	0.535
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0013	0.0038	0.0035
Schistosoma mansoni	gliotactin	0.0023	0.0102	0.0859
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0102	0.0859
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0032	0.0154	1
Echinococcus granulosus	neuroligin	0.0023	0.0102	0.0859
Echinococcus multilocularis	carboxylesterase 5A	0.0137	0.0785	0.6609
Chlamydia trachomatis	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.006	0.0319	1
Plasmodium vivax	N-acetylglucosamine-1-phosphate transferase, putative	0.0007	0.0003	0.0167
Loa Loa (eye worm)	serotonin transporter b	0.0032	0.0154	0.1963
Onchocerca volvulus		0.0007	0.0003	0.0101
Echinococcus granulosus	thioredoxin glutathione reductase	0.001	0.0021	0.0181
Mycobacterium tuberculosis	Hypothetical protein	0.0011	0.0028	0.0019
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0421	0.5363
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0032	0.0154	1
Plasmodium falciparum	thioredoxin reductase	0.001	0.0021	0.1246
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0013	0.0038	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0154	0.1963
Echinococcus multilocularis	thioredoxin glutathione reductase	0.001	0.0021	0.0181
Brugia malayi	Carboxylesterase family protein	0.0023	0.0102	0.13
Mycobacterium leprae	ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0026	0.0122	0.0113
Loa Loa (eye worm)	dihydrofolate reductase	0.0009	0.0019	0.0236
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0023	0.0099	0.0833
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0024	0.011	0.0923
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0009	0.0019	0.0016
Onchocerca volvulus		0.0023	0.0102	0.4001
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0024	0.011	0.1397
Mycobacterium leprae	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0157	0.09	0.0892
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0022	0.0096	0.0087
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0032	0.0154	1
Brugia malayi	Carboxylesterase family protein	0.0137	0.0785	1
Onchocerca volvulus		0.0023	0.0099	0.3879
Echinococcus multilocularis	geminin	0.0205	0.1187	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0102	0.13
Toxoplasma gondii	thioredoxin reductase	0.001	0.0021	0.1392
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0013	0.0038	0.0029
Onchocerca volvulus		0.0023	0.0102	0.4001
Onchocerca volvulus		0.0024	0.011	0.4298
Mycobacterium tuberculosis	Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0026	0.0122	0.0113
Onchocerca volvulus		0.0049	0.0255	1
Mycobacterium ulcerans	glycosyltransferase	0.0008	0.0009	0.0006
Echinococcus granulosus	acetylcholinesterase	0.0137	0.0785	0.6609
Brugia malayi	Pre-SET motif family protein	0.0043	0.022	0.2798
Trypanosoma cruzi	trypanothione reductase, putative	0.001	0.0021	0.1246
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0023	0.0102	0.0093

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5174 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1885118

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1537111