Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 0.043 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0047 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0047 | 0.043 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0047 | 0.043 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.043 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 0.043 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0.043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0047 | 0.043 | 0.043 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.