TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.531 | Formula: C25H30N4O2
H donors: 1 H acceptors: 4 LogP: 4.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(n1ncc(n1)C(c1ccccc1)(c1ccccc1)O)N1CCC(CC1)C(C)(C)C
InChi: 1S/C25H30N4O2/c1-24(2,3)19-14-16-28(17-15-19)23(30)29-26-18-22(27-29)25(31,20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-13,18-19,31H,14-17H2,1-3H3
InChiKey: LPTMHNPBMQCQPG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	abhydrolase domain containing 11	Starlite/ChEMBL	No references
Homo sapiens	abhydrolase domain containing 11	Starlite/ChEMBL	References
Homo sapiens	lysophospholipase I	Starlite/ChEMBL	References
Homo sapiens	lysophospholipase II	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Toxoplasma gondii	phospholipase/carboxylesterase	Get druggable targets OG5_127329	All targets in OG5_127329
Cryptosporidium hominis	carboxylesterase	Get druggable targets OG5_127329	All targets in OG5_127329
Schistosoma mansoni	acyl-protein thioesterase 12 (lysophospholipase III)	Get druggable targets OG5_127329	All targets in OG5_127329
Plasmodium knowlesi	alpha/beta hydrolase, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Plasmodium berghei	alpha/beta hydrolase, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Chlamydia trachomatis	lysophospholipase esterase	Get druggable targets OG5_127329	All targets in OG5_127329
Mycobacterium ulcerans	hydrolase	Get druggable targets OG5_128173	All targets in OG5_128173
Echinococcus granulosus	acyl protein thioesterase 12	Get druggable targets OG5_127329	All targets in OG5_127329
Echinococcus multilocularis	acyl protein thioesterase 1	Get druggable targets OG5_127329	All targets in OG5_127329
Schistosoma mansoni	acyl-protein thioesterase 12 (lysophospholipase III)	Get druggable targets OG5_127329	All targets in OG5_127329
Leishmania braziliensis	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Trypanosoma brucei	Alpha/beta hydrolase family, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Schistosoma mansoni	acyl-protein thioesterase 12 (lysophospholipase III)	Get druggable targets OG5_127329	All targets in OG5_127329
Plasmodium vivax	alpha/beta hydrolase, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127329	All targets in OG5_127329
Brugia malayi	hydrolase, alpha/beta fold family protein	Get druggable targets OG5_128173	All targets in OG5_128173
Candida albicans	match to pfam alpha/beta hydrolase fold	Get druggable targets OG5_128173	All targets in OG5_128173
Candida albicans	similar to S. cerevisiae YGR031W	Get druggable targets OG5_128173	All targets in OG5_128173
Candida albicans	similar to S. cerevisiae YGR031W	Get druggable targets OG5_128173	All targets in OG5_128173
Echinococcus multilocularis	abhydrolase domain containing protein 11	Get druggable targets OG5_128173	All targets in OG5_128173
Wolbachia endosymbiont of Brugia malayi	esterase	Get druggable targets OG5_127329	All targets in OG5_127329
Trypanosoma cruzi	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Candida albicans	likely Phospholipase/Carboxylesterase similar to S. cerevisiae YLR118C	Get druggable targets OG5_127329	All targets in OG5_127329
Leishmania donovani	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Mycobacterium tuberculosis	Possible hydrolase	Get druggable targets OG5_128173	All targets in OG5_128173
Plasmodium falciparum	alpha/beta hydrolase, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Candida albicans	likely Phospholipase/Carboxylesterase similar to S. cerevisiae YLR118C	Get druggable targets OG5_127329	All targets in OG5_127329
Plasmodium yoelii	putative esterase/lipase hi0193	Get druggable targets OG5_128173	All targets in OG5_128173
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_128173	All targets in OG5_128173
Neospora caninum	hydrolase, alpha/beta fold family domain- containing protein, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Leishmania donovani	Alpha/beta hydrolase family, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Leishmania major	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Brugia malayi	Phospholipase/Carboxylesterase family protein	Get druggable targets OG5_127329	All targets in OG5_127329
Trypanosoma brucei	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128173	All targets in OG5_128173
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_128173	All targets in OG5_128173
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_128173	All targets in OG5_128173
Echinococcus granulosus	acyl protein thioesterase 1	Get druggable targets OG5_127329	All targets in OG5_127329
Loa Loa (eye worm)	phospholipase/Carboxylesterase	Get druggable targets OG5_127329	All targets in OG5_127329
Leishmania mexicana	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Trypanosoma congolense	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Candida albicans	match to pfam alpha/beta hydrolase fold	Get druggable targets OG5_128173	All targets in OG5_128173
Trypanosoma cruzi	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Schistosoma japonicum	ko:K01175 ABHD11,abhydrolase domain containing 11 [EC:3.1.-.-], putative	Get druggable targets OG5_128173	All targets in OG5_128173
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	Get druggable targets OG5_128173	All targets in OG5_128173
Echinococcus multilocularis	acyl protein thioesterase 12	Get druggable targets OG5_127329	All targets in OG5_127329
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_128173	All targets in OG5_128173
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_128173	All targets in OG5_128173
Neospora caninum	hypothetical protein	Get druggable targets OG5_127329	All targets in OG5_127329
Trypanosoma congolense	Alpha/beta hydrolase family, putative	Get druggable targets OG5_128173	All targets in OG5_128173
Echinococcus granulosus	abhydrolase domain containing protein 11	Get druggable targets OG5_128173	All targets in OG5_128173
Schistosoma mansoni	family S33 non-peptidase homologue (S33 family)	Get druggable targets OG5_128173	All targets in OG5_128173
Trypanosoma brucei gambiense	lysophospholipase, putative,alpha/beta hydrolase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Leishmania infantum	lysophospholipase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Schistosoma japonicum	ko:K06130 lysophospholipase II, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Cryptosporidium parvum	carboxylesterase, putative	Get druggable targets OG5_127329	All targets in OG5_127329
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_127329	All targets in OG5_127329

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Possible peroxidase BpoB (non-haem peroxidase)	abhydrolase domain containing 11	227 aa	238 aa	26.9 %
Trypanosoma brucei	lysophospholipase, putative	lysophospholipase I	196 aa	207 aa	29.9 %
Leishmania major	hypothetical protein, conserved	abhydrolase domain containing 11	159 aa	130 aa	28.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.05	0.05
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.2398	1	1
Entamoeba histolytica	p21-activated kinase	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	casein kinase I isoform delta, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase DCAMKL3, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Echinococcus multilocularis	abhydrolase domain containing protein 11	0.0141	0.05	0.05
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2398	1	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Echinococcus multilocularis	mitogen activated protein kinase	0.2398	1	1
Trypanosoma brucei	protein kinase, putative	0.2398	1	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2398	1	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	mitogen-activated protein kinase	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0139	0.0492	0.0492
Entamoeba histolytica	casein kinase, putative	0.0022	0	0.5
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.2398	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Toxoplasma gondii	phospholipase/carboxylesterase	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2398	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Echinococcus granulosus	mitogen activated protein kinase	0.2398	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0101	0.0101
Echinococcus granulosus	acyl protein thioesterase 12	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase 2, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0139	0.0492	0.0492
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Plasmodium vivax	alpha/beta hydrolase, putative	0.0141	0.05	1
Entamoeba histolytica	hypothetical protein, conserved	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2398	1	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	cell division protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Wolbachia endosymbiont of Brugia malayi	esterase	0.0073	0.0216	0.5
Entamoeba histolytica	protein kinase with WD repeats	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase 3, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0022	0	0.5
Entamoeba histolytica	HEAT repeat domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Trypanosoma brucei	lysophospholipase, putative	0.0073	0.0216	0.0216
Schistosoma mansoni	acyl-protein thioesterase 12 (lysophospholipase III)	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Echinococcus granulosus	abhydrolase domain containing protein 11	0.0141	0.05	0.05
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	Rab GTPase activating protein, putative	0.0022	0	0.5
Loa Loa (eye worm)	phospholipase/Carboxylesterase	0.0073	0.0216	0.0216
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2398	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase C823.03, putative	0.0022	0	0.5
Entamoeba histolytica	cell division protein kinase 2, putative	0.0022	0	0.5
Schistosoma mansoni	acyl-protein thioesterase 12 (lysophospholipase III)	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2398	1	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Chlamydia trachomatis	lysophospholipase esterase	0.0073	0.0216	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	predicted protein	0.0022	0	0.5
Schistosoma mansoni	family S33 non-peptidase homologue (S33 family)	0.0141	0.05	0.05
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Leishmania major	hypothetical protein, conserved	0.0139	0.0492	0.0492
Leishmania major	lysophospholipase, putative	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Echinococcus multilocularis	acyl protein thioesterase 1	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2398	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2398	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	cell division protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Schistosoma mansoni	acyl-protein thioesterase 12 (lysophospholipase III)	0.0073	0.0216	0.0216
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Echinococcus granulosus	mitogen activated protein kinase 3	0.2398	1	1
Onchocerca volvulus	Transmembrane 9 superfamily member 4 homolog	0.0046	0.0101	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Trypanosoma cruzi	lysophospholipase, putative	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Mycobacterium tuberculosis	Possible hydrolase	0.0139	0.0492	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2398	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	casein kinase II alpha subunit, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.2398	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0022	0	0.5
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0139	0.0492	0.0492
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	cyclin-dependent kinase protein, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase STE20, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0139	0.0492	0.0492
Trichomonas vaginalis	CMGC family protein kinase	0.2398	1	1
Trypanosoma cruzi	lysophospholipase, putative	0.0073	0.0216	0.0216
Entamoeba histolytica	cell division protein kinase 2, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Brugia malayi	Phospholipase/Carboxylesterase family protein	0.0073	0.0216	0.0216
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.2398	1	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0022	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0022	0	0.5
Echinococcus granulosus	acyl protein thioesterase 1	0.0073	0.0216	0.0216
Giardia lamblia	Kinase, CMGC MAPK	0.2398	1	1
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0139	0.0492	0.0492
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase , putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	casein kinase 1, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0022	0	0.5
Echinococcus multilocularis	acyl protein thioesterase 12	0.0073	0.0216	0.0216
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2398	1	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0022	0	0.5
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0141	0.05	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Mycobacterium ulcerans	hydrolase	0.0139	0.0492	1
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0022	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0022	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 17 nM	Inhibition of human APT1	ChEMBL.	25558349
IC50 (binding)	< 30 nM	Inhibition of ABHD11 (unknown origin)	ChEMBL.	25558349
IC50 (binding)	= 30 nM	Inhibition of human APT2	ChEMBL.	25558349
IC50 (functional)	0.01 uM	PUBCHEM_BIOASSAY: Late stage assay provider results from the probe development effort to identify inhibitors of LYPLA1 and LYPLA2: Gel-based Activity-Based Protein Profiling (ABPP) IC50 for off-target ABHD11. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2174, AID2202, AID2203, AID2233, AID504482, AID504498, AID504505, AID504507, AID504510, AID504520, AID504522, AID504892]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1903566

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1537252