Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.0686 | 0.0686 |
Brugia malayi | Hexokinase family protein | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0418 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0129 | 0.2901 | 0.2901 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Treponema pallidum | hexokinase (hxk) | 0.0418 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0418 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.0622 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0418 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0418 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0418 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0133 | 0.2989 | 0.2989 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.0686 | 0.0686 |
Loa Loa (eye worm) | hexokinase type II | 0.0418 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.0622 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2989 | 0.2989 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0558 | 0.0558 |
Toxoplasma gondii | hexokinase | 0.0418 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0418 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0418 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0418 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0418 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0418 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0418 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0418 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0774 | 0.0774 |
Entamoeba histolytica | hexokinase 2 | 0.0418 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0262 | 0.6169 | 0.6169 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2989 | 0.2989 |
Loa Loa (eye worm) | hexokinase | 0.0129 | 0.2901 | 0.2901 |
Echinococcus multilocularis | hexokinase | 0.0418 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0418 | 1 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.0686 | 0.0686 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.0686 | 0.0686 |
Trypanosoma brucei | hexokinase, putative | 0.0418 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0418 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0418 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0262 | 0.6169 | 0.6169 |
Loa Loa (eye worm) | hexokinase | 0.0418 | 1 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Entamoeba histolytica | hexokinase 1 | 0.0418 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0774 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.6732 | 0.6732 |
Leishmania major | hexokinase, putative | 0.0418 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 8 nM | Inhibition of [3H]-AVP binding to recombinant human vasopressin V2 receptor | ChEMBL. | 15125926 |
Ki (binding) | = 8 nM | Inhibition of [3H]-AVP binding to recombinant human vasopressin V2 receptor | ChEMBL. | 15125926 |
Ki (binding) | = 18 nM | Inhibition of [3H]-AVP binding to recombinant human vasopressin V1a receptor | ChEMBL. | 15125926 |
Ki (binding) | = 18 nM | Inhibition of [3H]-AVP binding to recombinant human vasopressin V1a receptor | ChEMBL. | 15125926 |
Ki (functional) | = 0.023 uM | Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor | ChEMBL. | 15125926 |
Ki (functional) | = 0.023 uM | Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor | ChEMBL. | 15125926 |
Ki (binding) | = 14 uM | Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor | ChEMBL. | 15125926 |
Ki (binding) | = 14 uM | Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor | ChEMBL. | 15125926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.