Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0171 | 0.1268 | 0.1268 |
Leishmania major | trypanothione reductase | 0.0141 | 0.0956 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0171 | 0.1268 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.101 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0141 | 0.0956 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0171 | 0.1268 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.101 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0171 | 0.1268 | 0.1268 |
Echinococcus multilocularis | acetylcholinesterase | 0.101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Onchocerca volvulus | 0.0171 | 0.1268 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0141 | 0.0956 | 1 |
Onchocerca volvulus | 0.0171 | 0.1268 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.101 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.101 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0049 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0141 | 0.0956 | 0.7542 |
Treponema pallidum | NADH oxidase | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0141 | 0.0956 | 0.0956 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.1268 | 0.1268 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0171 | 0.1268 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0171 | 0.1268 | 0.1268 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0171 | 0.1268 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0171 | 0.1268 | 0.0345 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Schistosoma mansoni | acetylcholinesterase | 0.0171 | 0.1268 | 0.1268 |
Plasmodium vivax | glutathione reductase, putative | 0.0141 | 0.0956 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0141 | 0.0956 | 0.0956 |
Onchocerca volvulus | 0.0171 | 0.1268 | 0.5 | |
Onchocerca volvulus | 0.0171 | 0.1268 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.1268 | 0.1268 |
Brugia malayi | Carboxylesterase family protein | 0.101 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0141 | 0.0956 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0141 | 0.0956 | 0.0956 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0171 | 0.1268 | 0.1268 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0171 | 0.1268 | 0.1268 |
Echinococcus multilocularis | carboxylesterase 5A | 0.101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1268 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Echinococcus granulosus | acetylcholinesterase | 0.101 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0171 | 0.1268 | 1 |
Brugia malayi | glutathione reductase | 0.0141 | 0.0956 | 0.0956 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Schistosoma mansoni | gliotactin | 0.0171 | 0.1268 | 0.1268 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.1268 | 0.1268 |
Plasmodium falciparum | thioredoxin reductase | 0.0141 | 0.0956 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0171 | 0.1268 | 0.0345 |
Trypanosoma brucei | trypanothione reductase | 0.0141 | 0.0956 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.101 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0171 | 0.1268 | 0.1268 |
Echinococcus granulosus | neuroligin | 0.0171 | 0.1268 | 0.1268 |
Toxoplasma gondii | thioredoxin reductase | 0.0141 | 0.0956 | 1 |
Onchocerca volvulus | 0.0171 | 0.1268 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0171 | 0.1268 | 0.1268 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0171 | 0.1268 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.