Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1004 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1004 | 0.2022 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.1004 | 0.2022 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1004 | 0.2022 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2503 | 0.2503 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.1004 | 0.2022 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.1004 | 0.2022 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.1004 | 0.2022 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4963 | 0.4963 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1004 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1004 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2503 | 0.5043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.1004 | 0.2022 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.1004 | 0.2022 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.1004 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1004 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.1004 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1004 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.1004 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2503 | 0.5043 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2503 | 0.5043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1004 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1004 | 0.1004 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1004 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2503 | 0.5043 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.1004 | 0.2022 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.