Detailed information for compound 1537843

Basic information

Technical information
  • TDR Targets ID: 1537843
  • Name: (2-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrim idin-7-yl)methyl 3-(thiophene-2-carbonylamino )benzoate
  • MW: 440.495 | Formula: C20H16N4O4S2
  • H donors: 1 H acceptors: 3 LogP: 2.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nn2c(s1)nc(cc2=O)COC(=O)c1cccc(c1)NC(=O)c1cccs1
  • InChi: 1S/C20H16N4O4S2/c1-2-16-23-24-17(25)10-14(22-20(24)30-16)11-28-19(27)12-5-3-6-13(9-12)21-18(26)15-7-4-8-29-15/h3-10H,2,11H2,1H3,(H,21,26)
  • InChiKey: KQUWZSUMQBXNST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[oxo-(2-thienyl)methyl]amino]benzoic acid (2-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • 3-(thiophene-2-carbonylamino)benzoic acid (2-ethyl-5-keto-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • (2-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl 3-(thiophen-2-ylcarbonylamino)benzoate
  • G357-0587
  • NCGC00130690-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0328 0.4589
Mycobacterium tuberculosis Conserved protein 0.0036 0.0328 0.0652
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0174 0.0829
Mycobacterium tuberculosis Conserved protein 0.0036 0.0328 0.0652
Schistosoma mansoni hypothetical protein 0.0047 0.0459 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0267 0.0678
Toxoplasma gondii ABC1 family protein 0.0036 0.0328 0.524
Schistosoma mansoni hypothetical protein 0.0024 0.0182 0.0155
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0163 0.2668
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0068 0.0106
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0068 0.0106
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0267 0.0241
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0267 0.5468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0107 0.0448
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0227
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0539 1
Schistosoma mansoni nuclear receptor 0.0015 0.0068 0.0042
Brugia malayi hypothetical protein 0.0016 0.009 0.016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0328 0.0652
Schistosoma mansoni hypothetical protein 0.0047 0.0459 0.0433
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0356 1
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0163 0.0163
Echinococcus multilocularis GPCR, family 2 0.0047 0.0459 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0267 0.0614
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0227
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0459 0.1166
Echinococcus granulosus importin subunit beta 1 0.0029 0.0241 0.0241
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0267 0.0241
Loa Loa (eye worm) TAR-binding protein 0.0333 0.3936 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.268 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0267 0.0267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0267 0.0614
Brugia malayi chromobox protein homolog 3 0.0038 0.0356 0.0843
Schistosoma mansoni ran 0.0021 0.0148 0.0122
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0328 0.0652
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0267 0.5468
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0267 0.0241
Schistosoma mansoni cpg binding protein 0.0031 0.0263 0.0237
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1589 0.3997
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0047 0.0119
Schistosoma mansoni zinc finger protein 0.0015 0.0068 0.0042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0399 0.2089
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0356 1
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0068 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0068 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0107 0.0448
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0267 0.0241
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Schistosoma mansoni hypothetical protein 0.0047 0.0459 0.0433
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0267 0.0241
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0399 0.6482
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1118 0.2791
Brugia malayi Heterochromatin protein 1 0.0068 0.0721 0.1776
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0356 0.6438
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1686 0.4244
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0241 0.2363
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0027
Brugia malayi hypothetical protein 0.0016 0.009 0.016
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0267 0.0267
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0068 0.0173
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0328 0.0832
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0068 0.0068
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1618 0.1618
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0328 0.0769
Loa Loa (eye worm) helicase 0.0011 0.0027 0.0068
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0539 1
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0158 0.1807 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0328 0.0328
Brugia malayi Importin beta-1 subunit 0.0029 0.0241 0.0547
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0328 0.0652
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0539 1
Brugia malayi SET domain containing protein 0.0012 0.0035 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0267 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3936 0.392
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0267 0.0267
Brugia malayi Inositol-1 0.0036 0.0331 0.0778
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0163 0.2668
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0163 0.5
Onchocerca volvulus 0.0015 0.0068 0.0944
Schistosoma mansoni inositol monophosphatase 0.0036 0.0331 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0267 0.0614
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0068 0.0106
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1618 0.1595
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0392 0.2049
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0328 0.0998
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0328 0.4589
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3936 0.392
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3936 0.392
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0832
Echinococcus granulosus Chromobox protein 3 0.0011 0.0027 0.0027
Loa Loa (eye worm) beta-lactamase 0.0036 0.0328 0.0832
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0832
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0267 0.0267
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0267 0.0241
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0227
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.007 0.0241
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0267 0.0614
Plasmodium falciparum importin beta, putative 0.0029 0.0241 0.4175
Echinococcus multilocularis chromobox protein 2 0.0011 0.0027 0.0027
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0068 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.009 0.016
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0068 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1589 0.1589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1589 0.1567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0267 0.0678
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0328 0.1689
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0241 0.2363
Mycobacterium ulcerans beta-lactamase 0.0036 0.0328 0.0998
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.4678
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0267 0.0678
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0068 0.0106
Loa Loa (eye worm) DR-78 0.0015 0.0068 0.0173
Mycobacterium ulcerans hypothetical protein 0.0158 0.1807 1
Brugia malayi nuclear receptor RXR 0.0016 0.009 0.016
Echinococcus multilocularis chromobox protein 1 0.0068 0.0721 0.0721
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0267 0.0267
Schistosoma mansoni hypothetical protein 0.0346 0.4094 0.4078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0328 0.0998
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0267 0.0614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1686 0.4283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0107 0.0448
Brugia malayi steroid hormone receptor 0.0031 0.0267 0.0614
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0267 0.0614
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0267 0.0241
Onchocerca volvulus 0.0015 0.0068 0.0944
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0101 0.1118 0.284
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0068 0.0106
Echinococcus multilocularis tar DNA binding protein 0.0333 0.3936 0.3936
Brugia malayi beta-lactamase family protein 0.0036 0.0328 0.0769
Schistosoma mansoni hypothetical protein 0.0047 0.0459 0.0433
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0328 0.1689
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0331 0.1708
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1589 0.1567
Echinococcus multilocularis snurportin 1 0.0308 0.3623 0.3623
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1686 0.4244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0227
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0399 0.7264
Echinococcus granulosus geminin 0.0346 0.4094 0.4094
Schistosoma mansoni hypothetical protein 0.0101 0.1118 0.1094
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Onchocerca volvulus 0.0036 0.0328 0.6853
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0331 0.1708
Brugia malayi CXXC zinc finger family protein 0.0029 0.0243 0.0554
Echinococcus granulosus Chromo domain 0.0011 0.0027 0.0027
Mycobacterium tuberculosis Probable aminotransferase 0.0158 0.1807 0.6532
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0163 0.238
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0267 0.0241
Echinococcus granulosus chromobox protein 2 0.0011 0.0027 0.0027
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0068 0.0068
Schistosoma mansoni importin beta-1 0.0029 0.0241 0.0214
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0331 0.1708
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0068 0.0042
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.022 0.1087
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0107 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0267 0.0614
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.007 0.0241
Trichomonas vaginalis esterase, putative 0.0036 0.0328 0.1689
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0399 0.2089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0029 0.0241 0.0611
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0163 0.0163
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0148 0.2117
Brugia malayi nuclear receptor NHR-88 0.0031 0.0267 0.0614
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.4678
Brugia malayi conserved hypotetical protein 0.0015 0.0068 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0035 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.009 0.016
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0331 1
Brugia malayi RNA recognition motif domain containing protein 0.0333 0.3936 1
Echinococcus granulosus snurportin 1 0.0308 0.3623 0.3623
Onchocerca volvulus 0.0012 0.0035 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Schistosoma mansoni hypothetical protein 0.0346 0.4094 0.4078
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.009 0.009
Mycobacterium ulcerans lipase LipD 0.0036 0.0328 0.0998
Echinococcus multilocularis cpg binding protein 0.0031 0.0263 0.0263
Brugia malayi nuclear hormone receptor 0.0031 0.0267 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0267 0.0614
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0331 0.0331
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0267 0.0267
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0539 0.8923
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0832
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0459 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0267 0.0678
Loa Loa (eye worm) hypothetical protein 0.0047 0.0459 0.1166
Brugia malayi hypothetical protein 0.0232 0.2708 0.6859
Brugia malayi nuclear receptor NHR-67 0.0015 0.0068 0.0106
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0027 0.0027
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0158 0.1807 0.6532
Schistosoma mansoni ran 0.0021 0.0148 0.0122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0459 0.0459
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0068 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0064 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0267 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0267 0.0614
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0068 0.0173
Brugia malayi beta-lactamase 0.0036 0.0328 0.0769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0267 0.0267
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0285 0.0739
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0267 0.0678
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.065
Brugia malayi ecdysteroid receptor 0.0031 0.0267 0.0614
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0267 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0267 0.0614
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2708 0.2708
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3936 0.392
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0459 0.1105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0148 0.2372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0267 0.0678
Brugia malayi ecdysone receptor 0.0015 0.0068 0.0106
Loa Loa (eye worm) hypothetical protein 0.0148 0.1686 0.4283
Schistosoma mansoni coup transcription factor 0.0031 0.0267 0.0241
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0328 0.1689
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0328 0.5872
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0356 0.7508
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1618 0.4069
Echinococcus multilocularis Chromo domain 0.0011 0.0027 0.0027
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.009 0.009
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0047 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Leishmania major hypothetical protein, conserved 0.0053 0.0539 1
Leishmania major hypothetical protein, conserved 0.0036 0.0328 0.4589
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0148 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0068 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0267 0.0614
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0163 0.0137
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0328 0.0328
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0148 0.0311
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0148 0.0377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Brugia malayi hypothetical protein 0.0015 0.0068 0.0106
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0068 0.0068
Onchocerca volvulus 0.0029 0.0243 0.4932
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0107 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0328 0.4589
Brugia malayi RNA, U transporter 1 0.0082 0.0885 0.2196
Brugia malayi hypothetical protein 0.0053 0.0539 0.131
Loa Loa (eye worm) RNA binding protein 0.0333 0.3936 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0068 0.0068
Schistosoma mansoni survival motor neuron protein 0.0047 0.0466 0.044
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0832
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0328 0.1689
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0107 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0241 0.3725
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0267 0.0241
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0328 0.0652
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0068 0.0944
Brugia malayi beta-lactamase family protein 0.0036 0.0328 0.0769
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0241 0.0241
Brugia malayi tailless protein 0.0015 0.0068 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0267 0.0614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0267 0.0678
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0107 0.0448
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0267 0.0267
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0068 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0832
Echinococcus granulosus cpg binding protein 0.0031 0.0263 0.0263
Leishmania major importin beta-1 subunit, putative 0.0023 0.0174 0.067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0068
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0174 0.067
Echinococcus granulosus chromobox protein 1 0.0068 0.0721 0.0721
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.009 0.0063
Schistosoma mansoni nuclear receptor 0.0015 0.0068 0.0042
Brugia malayi nuclear receptor RXR 0.0015 0.0068 0.0106
Echinococcus granulosus GPCR family 2 0.0047 0.0459 0.0459
Onchocerca volvulus 0.0047 0.0466 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0267 0.0678
Echinococcus granulosus Aminotransferase class III 0.0022 0.0163 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0328 0.1689
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0158 0.1807 1
Schistosoma mansoni hypothetical protein 0.0308 0.3623 0.3606
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0328 0.0652
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0392 0.2049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0174 0.0829
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0267 0.0267
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0721 0.3899
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0331 0.1019
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.022 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0356 0.185
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0721 0.3899
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0285 0.0483
Loa Loa (eye worm) inositol-1 0.0036 0.0331 0.0841
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0158 0.1807 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0148 0.2372
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0392 0.8313
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0227
Schistosoma mansoni hypothetical protein 0.0047 0.0466 0.044
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0267 0.5468
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0721 0.1832
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0267 0.0267
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0459 0.1105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0638 0.0613
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0163 0.0163
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0068 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0267 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0267 0.0267
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0331 0.9228
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0331 0.5301
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0163 0.0163
Schistosoma mansoni cpg binding protein 0.0029 0.0243 0.0217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0267 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0243 0.0618
Schistosoma mansoni chromobox protein 0.0068 0.0721 0.0696
Brugia malayi CHD4 protein 0.0013 0.0047 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0267 0.0614
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0068 0.0068
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0068 0.0068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0068 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0459 0.0459
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0107 0.0448
Brugia malayi nuclear receptor NHR-88 0.0015 0.0068 0.0106
Entamoeba histolytica Ran family GTPase 0.0021 0.0148 0.3684
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0163 0.0349
Schistosoma mansoni inositol monophosphatase 0.0036 0.0331 0.0305
Echinococcus multilocularis geminin 0.0346 0.4094 0.4094
Brugia malayi nuclear hormone receptor 0.0015 0.0068 0.0106
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0328 0.0652
Loa Loa (eye worm) hypothetical protein 0.0232 0.2708 0.688
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0832
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0267 0.0267
Trichomonas vaginalis ran, putative 0.0021 0.0148 0.0682
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0068 0.0944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1589 0.1589
Echinococcus multilocularis chromobox protein 1 0.0068 0.0721 0.0721
Onchocerca volvulus 0.003 0.0256 0.5217
Brugia malayi hypothetical protein 0.0034 0.0309 0.0722
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0174 0.0829
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.4678
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0328 0.0301
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0267 0.0241
Mycobacterium tuberculosis Conserved protein 0.0036 0.0328 0.0652
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0267 0.0614
Schistosoma mansoni cpg binding protein 0.0031 0.0263 0.0237
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0328 0.0998
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1569 0.1569
Schistosoma mansoni chromobox protein 0.0068 0.0721 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0267 0.0614
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0399 0.6482
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0267 0.0241
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0068 0.0068
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0678
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0267 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0356 0.185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0328 0.0301
Brugia malayi RNA binding protein 0.0333 0.3936 1
Onchocerca volvulus 0.0031 0.0267 0.5468
Mycobacterium leprae Probable lipase LipE 0.0036 0.0328 0.0998
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.4678
Plasmodium vivax importin-beta 2, putative 0.0029 0.0241 0.4175
Loa Loa (eye worm) acetyltransferase 0.0142 0.1618 0.411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1589 0.1567
Brugia malayi TAR-binding protein 0.0333 0.3936 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0328 0.0652
Echinococcus granulosus chromobox protein 1 0.0068 0.0721 0.0721
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1589 0.4038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.009 0.0063
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0333 0.3936 1
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2708 0.2708
Mycobacterium ulcerans hypothetical protein 0.0036 0.0328 0.0998
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0182 0.0182
Echinococcus granulosus tar DNA binding protein 0.0333 0.3936 0.3936
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0068 0.0173
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0601 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0182 0.0182
Brugia malayi hypothetical protein 0.0015 0.0068 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3936 0.392
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0905
Loa Loa (eye worm) hypothetical protein 0.0053 0.0539 0.1369
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.3623 0.9205
Onchocerca volvulus 0.0036 0.0328 0.6853
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0466 0.1122
Onchocerca volvulus 0.0036 0.0328 0.6853
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0173
Entamoeba histolytica hypothetical protein 0.0023 0.0174 0.4479

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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