Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.128 | 0.3031 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.06 | 0.0919 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.06 | 0.0919 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.128 | 0.3031 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0527 | 0.069 | 0.2276 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.128 | 0.3031 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.128 | 0.3031 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.128 | 0.3031 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.128 | 0.3031 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.06 | 0.0919 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.06 | 0.0919 | 1 |
Schistosoma mansoni | patched 1 | 0.0527 | 0.069 | 0.2276 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0527 | 0.069 | 0.2276 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.128 | 0.3031 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0527 | 0.069 | 0.2276 |
Loa Loa (eye worm) | hypothetical protein | 0.128 | 0.3031 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.128 | 0.3031 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.128 | 0.3031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.069 | 0.2276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 50 % | Tested for inhibition of rat glial cell gap junction at the concentration of 20 microM | ChEMBL. | 10328303 |
Inhibition (functional) | = 100 % | Inhibition of rat glial cell gap junction at the concentration of 50 microM | ChEMBL. | 10328303 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.