Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0097 | 0.2284 | 0.2284 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0707 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0707 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.3541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2284 | 0.1697 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0707 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.3541 | 0.3541 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0707 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.3541 | 0.3049 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0097 | 0.2284 | 0.1697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3541 | 0.3032 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0707 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3541 | 0.3032 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.3541 | 0.3541 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0707 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3541 | 0.3032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3541 | 0.3032 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0707 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3541 | 0.3032 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0707 | 0.0707 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0306 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.3541 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0097 | 0.2284 | 0.2284 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.3541 | 0.3049 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0707 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.3541 | 0.3049 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.6429 | 0.6157 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0257 | 0.8206 | 0.807 |
Schistosoma mansoni | hypothetical protein | 0.0209 | 0.6429 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0257 | 0.8206 | 0.8206 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0209 | 0.6429 | 0.6429 |
Brugia malayi | RNA binding protein | 0.0131 | 0.3541 | 0.3541 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0257 | 0.8206 | 0.807 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.