Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | oxidoreductase | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0379 | 0.4092 | 0.4866 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0752 | 0.8409 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0752 | 0.8409 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0087 | 0.0104 |
Leishmania major | oxidoreductase-like protein | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0166 | 0.0094 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0288 | 0.3037 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0074 | 0.0087 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0288 | 0.3037 | 0.3544 |
Leishmania major | nitrate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0752 | 0.8409 | 1 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0086 | 0.0698 | 0.0698 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0752 | 0.8409 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0166 | 0.0094 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0086 | 0.0698 | 0.0733 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0288 | 0.3037 | 0.5 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0752 | 0.8409 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0086 | 0.0698 | 0.083 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0087 | 0.0104 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0752 | 0.8409 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0288 | 0.3037 | 0.3033 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0086 | 0.0698 | 0.0698 |
Trypanosoma brucei | nitrate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0166 | 0.0094 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0752 | 0.8409 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0752 | 0.8409 | 1 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0086 | 0.0698 | 0.0646 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0086 | 0.0698 | 0.083 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0166 | 0.0094 |
Onchocerca volvulus | 0.0086 | 0.0698 | 0.257 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0166 | 0.0094 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0166 | 0.0197 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0288 | 0.3037 | 0.3483 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0034 | 0.01 | 0.01 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0405 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.4032 | 0.474 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.8409 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.5656 | 0.6692 |
Giardia lamblia | Hypothetical protein | 0.0667 | 0.742 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0228 | 0.235 | 0.2795 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0086 | 0.0698 | 0.083 |
Chlamydia trachomatis | sulfite reductase | 0.0464 | 0.5081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0166 | 0.0094 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0087 | 0.0104 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0288 | 0.3037 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.026 | 0.2715 | 0.3093 |
Leishmania major | p450 reductase, putative | 0.0752 | 0.8409 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0752 | 0.8409 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0087 | 0.0104 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0228 | 0.235 | 0.2719 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0086 | 0.0698 | 0.2161 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0405 | 0.0481 |
Onchocerca volvulus | 0.004 | 0.0166 | 0.061 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.01 | 0.0015 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0752 | 0.8409 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0117 | 0.1059 | 0.1259 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0288 | 0.3037 | 0.3483 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0087 | 0.0087 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0109 | 0.097 | 0.0976 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0086 | 0.0698 | 0.0646 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0086 | 0.0698 | 0.2161 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.01 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0185 | 0.0117 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0109 | 0.097 | 0.0976 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0166 | 0.0094 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0288 | 0.3037 | 0.3483 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0464 | 0.5081 | 0.6001 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0034 | 0.01 | 0.01 |
Echinococcus granulosus | methionine synthase reductase | 0.0464 | 0.5081 | 0.6042 |
Onchocerca volvulus | 0.004 | 0.0166 | 0.061 | |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0086 | 0.0698 | 0.083 |
Brugia malayi | beta-lactamase | 0.004 | 0.0166 | 0.0197 |
Brugia malayi | flavodoxin family protein | 0.0752 | 0.8409 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0166 | 0.0198 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0086 | 0.0698 | 0.2161 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0288 | 0.3037 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0752 | 0.8409 | 1 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0288 | 0.3037 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0373 | 0.4026 | 1 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | cytochrome B5 | 0.0086 | 0.0698 | 0.083 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0373 | 0.4026 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0166 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.4032 | 0.474 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.01 | 0.0119 |
Mycobacterium ulcerans | monooxygenase | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma cruzi | p450 reductase, putative | 0.0752 | 0.8409 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | diaphorase | 0.0086 | 0.0698 | 0.0733 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0166 | 0.0166 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0667 | 0.742 | 0.8811 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0127 | 0.1183 | 0.1406 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0166 | 0.0197 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.5656 | 0.6692 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0752 | 0.8409 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0086 | 0.0698 | 0.0646 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0086 | 0.0698 | 0.2161 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0374 | 0.4032 | 0.4794 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0288 | 0.3037 | 0.3483 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0667 | 0.742 | 1 |
Brugia malayi | diaphorase | 0.0086 | 0.0698 | 0.083 |
Treponema pallidum | flavodoxin | 0.0288 | 0.3037 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0752 | 0.8409 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.088 | 0.0953 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0288 | 0.3037 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0166 | 0.0197 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0086 | 0.0698 | 0.0733 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0166 | 0.0197 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0087 | 0.0104 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0086 | 0.0698 | 0.155 |
Echinococcus multilocularis | methionine synthase reductase | 0.0464 | 0.5081 | 0.5081 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0166 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0752 | 0.8409 | 1 |
Leishmania major | reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0752 | 0.8409 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0405 | 0.0381 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0087 | 0.0087 |
Brugia malayi | FAD binding domain containing protein | 0.0464 | 0.5081 | 0.6042 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0166 | 0.5 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0086 | 0.0698 | 0.083 |
Brugia malayi | flavodoxin family protein | 0.0288 | 0.3037 | 0.3611 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0288 | 0.3037 | 0.3483 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0086 | 0.0698 | 0.0646 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0288 | 0.3037 | 0.3483 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0373 | 0.4026 | 0.4787 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0252 | 0.2628 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0166 | 0.0197 |
Onchocerca volvulus | 0.004 | 0.0166 | 0.061 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0117 | 0.1059 | 0.1059 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0117 | 0.1059 | 0.1259 |
Brugia malayi | FAD binding domain containing protein | 0.0752 | 0.8409 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0087 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0185 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0405 | 0.0381 |
Echinococcus granulosus | voltage gated potassium channel | 0.0034 | 0.01 | 0.0119 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0752 | 0.8409 | 1 |
Onchocerca volvulus | 0.0033 | 0.0087 | 0.0322 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0034 | 0.01 | 0.0119 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0127 | 0.1183 | 0.1406 |
Schistosoma mansoni | amine GPCR | 0.0416 | 0.4519 | 0.5374 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0086 | 0.0698 | 0.0733 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0752 | 0.8409 | 0.8409 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0166 | 0.0094 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0464 | 0.5081 | 0.6042 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0117 | 0.1059 | 0.1167 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0086 | 0.0698 | 0.155 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0288 | 0.3037 | 0.3483 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0086 | 0.0698 | 0.0646 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0752 | 0.8409 | 0.8409 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Plasmodium vivax | hypothetical protein, conserved | 0.0288 | 0.3037 | 0.3544 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0374 | 0.4032 | 0.4794 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0086 | 0.0698 | 0.2161 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0185 | 0.0219 |
Onchocerca volvulus | 0.026 | 0.2715 | 1 | |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0667 | 0.742 | 0.88 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0086 | 0.0698 | 0.0646 |
Mycobacterium ulcerans | oxygenase | 0.0086 | 0.0698 | 0.0646 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0034 | 0.01 | 0.0119 |
Leishmania major | cytochrome P450 reductase, putative | 0.0667 | 0.742 | 0.88 |
Trypanosoma cruzi | p450 reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0288 | 0.3037 | 0.3483 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0086 | 0.0698 | 0.0646 |
Leishmania major | hypothetical protein, conserved | 0.0288 | 0.3037 | 0.3483 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0166 | 0.0094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.