Detailed information for compound 1538308

Basic information

Technical information
  • TDR Targets ID: 1538308
  • Name: N-tert-butyl-1-(2-chloro-4-morpholin-4-ylsulf onylphenyl)piperidine-4-carboxamide
  • MW: 443.988 | Formula: C20H30ClN3O4S
  • H donors: 1 H acceptors: 3 LogP: 2.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)c1ccc(cc1Cl)S(=O)(=O)N1CCOCC1)NC(C)(C)C
  • InChi: 1S/C20H30ClN3O4S/c1-20(2,3)22-19(25)15-6-8-23(9-7-15)18-5-4-16(14-17(18)21)29(26,27)24-10-12-28-13-11-24/h4-5,14-15H,6-13H2,1-3H3,(H,22,25)
  • InChiKey: YGMTTXSFUUMZIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-tert-butyl-1-(2-chloro-4-morpholinosulfonyl-phenyl)piperidine-4-carboxamide
  • N-tert-butyl-1-(2-chloro-4-morpholinosulfonylphenyl)-4-piperidinecarboxamide
  • N-tert-butyl-1-(2-chloro-4-morpholinosulfonyl-phenyl)isonipecotamide
  • N-tert-butyl-1-(2-chloro-4-morpholin-4-ylsulfonyl-phenyl)piperidine-4-carboxamide
  • ASN 07160599
  • MLS000715414
  • SMR000275393
  • ZINC01328944

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0176 0.0436
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0136 0.1507 0.1507
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0025 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0051 0.0078
Loa Loa (eye worm) hypothetical protein 0.0056 0.0569 0.0897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0333 0.0525
Toxoplasma gondii aldose reductase, putative 0.0009 0.0032 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Loa Loa (eye worm) hypothetical protein 0.0136 0.1502 0.237
Brugia malayi Augmenter of liver regeneration 0.0037 0.0349 0.055
Onchocerca volvulus 0.0011 0.0051 0.0339
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0176 0.0278
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0025 0.0037
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0025 0.004
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.035 0.3981 0.6282
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0333 0.0776
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0025 0.0025
Mycobacterium ulcerans lipase LipD 0.0035 0.0333 0.0487
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0118 0.0142
Onchocerca volvulus 0.0035 0.0333 0.2214
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0787 0.1207
Brugia malayi follicle stimulating hormone receptor 0.023 0.2593 0.4092
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0176 0.0276
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0094 0.0145
Echinococcus multilocularis aldo keto reductase 0.0009 0.0032 0.0032
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Brugia malayi Heterochromatin protein 1 0.0068 0.0708 0.1117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1024 0.1024
Giardia lamblia Pyruvate kinase 0.0018 0.0128 0.0297
Echinococcus granulosus snurportin 1 0.0372 0.4238 0.5084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0333 0.0399
Echinococcus multilocularis transcription factor Dp 1 0.012 0.1312 0.1312
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Giardia lamblia Pyruvate kinase 0.0035 0.0323 0.0861
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0141 0.0292
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0025 0.0025
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0323 0.0753
Giardia lamblia DINP protein human, muc B family 0.0021 0.0171 0.0421
Loa Loa (eye worm) glutaminase 2 0.0553 0.6337 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0327 0.0327
Leishmania major prostaglandin f synthase, putative 0.0009 0.0032 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0542 0.0855
Leishmania major pyruvate kinase 0.0035 0.0323 0.0753
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0207 0.2323 0.5807
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0569 0.1373
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0011 0.0051 0.0074
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0323 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.0118
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1024 0.1616
Loa Loa (eye worm) hypothetical protein 0.003 0.0268 0.0422
Brugia malayi hypothetical protein 0.0136 0.1502 0.237
Loa Loa (eye worm) hypothetical protein 0.0056 0.0569 0.0897
Toxoplasma gondii ABC1 family protein 0.0035 0.0333 0.0776
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0136 0.1507 0.2376
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0176 0.0381
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0051 0.0065
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0032 0.0019
Chlamydia trachomatis pyruvate kinase 0.0035 0.0323 0.5484
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0051 0.008
Echinococcus multilocularis pyruvate kinase 0.0027 0.0239 0.0239
Echinococcus granulosus geminin 0.0181 0.2028 0.2433
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0025 0.004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0787 0.1242
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0025 0.0025
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0202 0.051
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0176 0.0239
Echinococcus multilocularis lamin dm0 0.0028 0.0251 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0171 0.0171
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0333 0.0522
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0051 0.008
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Brugia malayi beta-lactamase family protein 0.0035 0.0333 0.0525
Trypanosoma brucei aldo/keto reductase, putative 0.0009 0.0032 0.0017
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0136 0.1507 0.4282
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3486 1
Onchocerca volvulus 0.0022 0.0176 0.1174
Schistosoma mansoni hypothetical protein 0.0181 0.2028 0.2433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1024 0.1228
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0323 0.051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0171 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Leishmania major hypothetical protein, conserved 0.0035 0.0333 0.0776
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0025 0.0031
Brugia malayi MH2 domain containing protein 0.0124 0.1357 0.2142
Trichomonas vaginalis importin beta-1, putative 0.0028 0.025 0.0392
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0333 0.0525
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0363 0.2415
Plasmodium falciparum pyruvate kinase 0.0035 0.0323 0.0753
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0051 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1024 0.1228
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0032 0.0051
Trypanosoma brucei unspecified product 0.0021 0.0171 0.0369
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Brugia malayi CHD4 protein 0.0013 0.0071 0.0112
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.8336 0.8336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0427 0.0427
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0099 0.0155
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0043 0.0427 0.0512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0128
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0333 0.0776
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0171 0.0369
Brugia malayi hypothetical protein 0.0011 0.0051 0.008
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0032 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.051
Echinococcus multilocularis geminin 0.0181 0.2028 0.2028
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0136 0.1507 0.2376
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0136 0.1507 0.1808
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0025 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0787 0.1926
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0025 0.0025
Echinococcus granulosus smad 0.0008 0.002 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1024 0.1024
Brugia malayi Smad1 0.0008 0.002 0.0032
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0025 0.0031
Echinococcus multilocularis pyruvate kinase 0.0018 0.0128 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0533 0.1284
Echinococcus granulosus aldo keto reductase 0.0009 0.0032 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0145
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0071 0.0071
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.035 0.3981 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0533 0.1284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.013 0.0203
Trypanosoma cruzi aldo-keto reductase 0.0009 0.0032 0.0017
Echinococcus granulosus dnaJ subfamily B 0.043 0.4909 0.5889
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0053 0.0542 0.0855
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0136 0.1507 0.2376
Leishmania major hypothetical protein, conserved 0.0037 0.0349 0.0817
Loa Loa (eye worm) calcium ATPase 0.0009 0.0025 0.004
Echinococcus multilocularis snurportin 1 0.0372 0.4238 0.4238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0207 0.2323 0.5807
Loa Loa (eye worm) glutaminase 0.0553 0.6337 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0136 0.1507 0.1507
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0349 0.0817
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.002 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0009 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0037
Schistosoma mansoni cpg binding protein 0.0032 0.0292 0.0351
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0251 0.0396
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0349 0.055
Onchocerca volvulus 0.003 0.0268 0.1782
Trichomonas vaginalis esterase, putative 0.0035 0.0333 0.0522
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Schistosoma mansoni chromobox protein 0.0068 0.0708 0.0849
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0171 0.0369
Loa Loa (eye worm) hypothetical protein 0.0024 0.0202 0.0319
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0333 0.0525
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0051 0.0078
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.8336 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0787 0.1926
Schistosoma mansoni pyruvate kinase 0.0035 0.0323 0.0388
Onchocerca volvulus 0.0035 0.0333 0.2214
Schistosoma mansoni lamin 0.0028 0.0251 0.0301
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.002 0.0024
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0025 0.0025
Leishmania major dihydroorotate dehydrogenase 0.035 0.3981 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0118 0.0142
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0171 0.0205
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0787 0.1926
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0025 0.0031
Echinococcus multilocularis tyrosine protein kinase Abl 0.0083 0.0888 0.0888
Echinococcus multilocularis Smad4 0.0008 0.002 0.002
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Schistosoma mansoni cpg binding protein 0.003 0.0273 0.0327
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0327 0.0762
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0025 0.004
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0787 0.1242
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.013 0.0203
Onchocerca volvulus 0.0074 0.0787 0.5241
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0176 0.0381
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0136 0.1507 0.3746
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0176 0.0239
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0323 0.0753
Onchocerca volvulus 0.0035 0.0333 0.2214
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0094 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0094 0.0173
Plasmodium falciparum importin beta, putative 0.0035 0.0327 0.0762
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.035 0.3981 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0176 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0363 0.057
Echinococcus granulosus aldo keto reductase 0.0009 0.0032 0.0038
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0051 0.0065
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0787 0.2201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0118 0.0187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0396 0.0623
Schistosoma mansoni hypothetical protein 0.0011 0.0051 0.0061
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0032 0.0017
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.035 0.3981 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0074 0.0787 0.1242
Loa Loa (eye worm) hypothetical protein 0.0035 0.0333 0.0525
Loa Loa (eye worm) hypothetical protein 0.0136 0.1502 0.237
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0273 0.043
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0171 0.0231
Brugia malayi MH1 domain containing protein 0.0008 0.002 0.0032
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0051 0.0065
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0044 0.0069
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0032 0.0051
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0176 0.0381
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0176 0.0381
Schistosoma mansoni ATPase 0.0009 0.0025 0.0031
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Schistosoma mansoni chromobox protein 0.0011 0.0051 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0009 0.0032 0.0017
Echinococcus granulosus dna polymerase eta 0.0021 0.0171 0.0205
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0333 0.0776
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0251 0.0396
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0032 0.0051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2543 0.6364
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1663 0.2595
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0176 0.0239
Schistosoma mansoni amine GPCR 0.0365 0.4164 0.4995
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Onchocerca volvulus Huntingtin homolog 0.0136 0.1502 1
Plasmodium falciparum aldo-keto reductase, putative 0.0009 0.0032 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0171 0.0268
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Echinococcus granulosus pyruvate kinase 0.0018 0.0128 0.0154
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0051 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0171 0.0205
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0032 0.0051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0171 0.0369
Echinococcus granulosus microtubule associated protein 2 0.0725 0.8336 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0333 0.0525
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1357 0.2142
Trypanosoma brucei unspecified product 0.0015 0.0094 0.0173
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0136 0.1507 0.2376
Loa Loa (eye worm) beta-lactamase 0.0035 0.0333 0.0525
Echinococcus multilocularis dna polymerase eta 0.0021 0.0171 0.0171
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0051 0.008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0787 0.1207
Brugia malayi hypothetical protein 0.0043 0.0427 0.0673
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0207 0.2323 0.2323
Echinococcus granulosus pyruvate kinase 0.0035 0.0323 0.0388
Loa Loa (eye worm) hypothetical protein 0.0093 0.0997 0.1573
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0025 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0787 0.1926
Mycobacterium leprae Possible oxidoreductase 0.0009 0.0032 0.0017
Schistosoma mansoni importin beta-1 0.0035 0.0327 0.0392
Echinococcus multilocularis aldo keto reductase 0.0009 0.0032 0.0032
Schistosoma mansoni ATPase 0.0009 0.0025 0.0031
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0787 0.1926
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1357 0.2142
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0025 0.0031
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0333 0.0333
Leishmania major DNA polymerase eta, putative 0.0021 0.0171 0.0369
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0032 0.0051
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0128 0.026
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0333 0.0399
Schistosoma mansoni cpg binding protein 0.0032 0.0292 0.0351
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.004
Loa Loa (eye worm) oxidoreductase 0.0009 0.0032 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0171 0.027
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0333 0.0525
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0349 0.0817
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1663 0.414
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0176 0.0381
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0031
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0176 0.0381
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.002 0.002
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.002 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Echinococcus multilocularis dnaJ subfamily B 0.043 0.4909 0.4909
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0051 0.0065
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.3486 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0171 0.0369
Mycobacterium tuberculosis Conserved protein 0.0009 0.0032 0.0017
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4238 0.6688
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Entamoeba histolytica hypothetical protein 0.0043 0.0427 0.116
Schistosoma mansoni aldo-keto reductase 0.0009 0.0032 0.0038
Brugia malayi hypothetical protein 0.0093 0.0997 0.1573
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0009 0.0032 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Leishmania major aldo-keto reductase-like protein 0.0009 0.0032 0.0017
Brugia malayi Zinc finger, C2H2 type family protein 0.0136 0.1507 0.2378
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0569 0.1373
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0025 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0333 0.0522
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0333 0.0487
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.035 0.3981 1
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0051 0.0078
Schistosoma mansoni hypothetical protein 0.043 0.4909 0.5889
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0176 0.0278
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0032 0.0051
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0025 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0665 0.0798
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.013 0.0203
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0327 0.0762
Mycobacterium leprae Probable lipase LipE 0.0035 0.0333 0.0776
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0051 0.0065
Echinococcus multilocularis Chromo domain 0.0011 0.0051 0.0051
Mycobacterium ulcerans hypothetical protein 0.0009 0.0032 0.001
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0176 0.0278
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0025 0.0037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0333 0.0487
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0202 0.0319
Entamoeba histolytica hypothetical protein 0.0028 0.025 0.065
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0032 0.0038
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0025 0.0037
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0176 0.0381
Entamoeba histolytica aldose reductase, putative 0.0009 0.0032 0.0019
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0009 0.0032 0.0017
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0327 0.0762
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0171 0.0369
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0136 0.1507 0.1808
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0787 0.1207
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Loa Loa (eye worm) oxidoreductase 0.0009 0.0032 0.0051
Loa Loa (eye worm) Smad1 0.0008 0.002 0.0032
Onchocerca volvulus 0.0022 0.0176 0.1174
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0176 0.0381
Leishmania major importin beta-1 subunit, putative 0.0028 0.025 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Brugia malayi SET domain containing protein 0.0012 0.0059 0.0092
Brugia malayi chromobox protein homolog 3 0.0038 0.0363 0.0572
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Mycobacterium ulcerans hypothetical protein 0.0035 0.0333 0.0487
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0025 0.0025
Onchocerca volvulus 0.0028 0.0251 0.1672
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0009 0.0011
Echinococcus granulosus GPCR family 2 0.0017 0.0118 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0059 0.007
Onchocerca volvulus 0.0009 0.0025 0.0169
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0009 0.0011
Schistosoma mansoni chromobox protein 0.0011 0.0051 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0787 0.1207
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0025 0.0031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0569 0.0861
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0346 0.0546
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.002 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.013 0.0203
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0323 0.0753
Schistosoma mansoni tyrosine kinase 0.0201 0.2257 0.2708
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Echinococcus granulosus pyruvate kinase 0.0035 0.0323 0.0388
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0025 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0136 0.1507 0.2376
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.1359 0.2144
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0176 0.0381
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0051 0.0061
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0142
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0176 0.0211
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0245 0.0387
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0032 0.0019
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0323 0.2152
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0025 0.0037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0071 0.0085
Leishmania major DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0204 0.2291 0.2291
Brugia malayi glutaminase DH11.1 0.0553 0.6337 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0032 0.0048
Entamoeba histolytica hypothetical protein 0.0011 0.0051 0.0074
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.0427 0.116
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0025 0.0037
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0323 0.051
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0176 0.0211
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0025 0.0031
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0025 0.004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0176 0.0278
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0207 0.2323 0.6638
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0025 0.0037
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0032 0.0032
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Echinococcus multilocularis pyruvate kinase 0.0035 0.0323 0.0323
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0176 0.0239
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0586 0.1417
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0032 0.0048
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0025 0.0037
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0009 0.0032 0.0017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0572
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0051
Onchocerca volvulus 0.0009 0.0032 0.0213
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Entamoeba histolytica hypothetical protein 0.0043 0.0427 0.116
Schistosoma mansoni aldo-keto reductase 0.0009 0.0032 0.0038
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0051 0.0065
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0051 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0051 0.0078
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0207 0.2323 0.2786
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0011 0.0051 0.0074
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0142
Onchocerca volvulus 0.0022 0.0176 0.1174
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0051 0.0065
Schistosoma mansoni dihydroorotate dehydrogenase 0.035 0.3981 0.4776
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0099 0.0155
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0176 0.0176
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Echinococcus granulosus chromobox protein 1 0.0068 0.0708 0.0849
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0323 0.2152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3486 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0176 0.0381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1024 0.1228
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0051 0.0061
Loa Loa (eye worm) oxidoreductase 0.0009 0.0032 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0171 0.027
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0081 0.0097
Schistosoma mansoni DNA polymerase eta 0.0021 0.0171 0.0205
Mycobacterium tuberculosis Conserved protein 0.0035 0.0333 0.0776
Schistosoma mansoni smad 0.0008 0.002 0.0024
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0396 0.2638
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0025 0.004
Echinococcus granulosus Chromobox protein 3 0.0011 0.0051 0.0061
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0025 0.004
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0708 0.1117
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0333 0.0522
Entamoeba histolytica aldose reductase, putative 0.0009 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0533 0.1284
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0031 0.0048
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0176 0.0381
Echinococcus granulosus pyruvate kinase 0.0018 0.0128 0.0154
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0025 0.0031
Echinococcus multilocularis GPCR, family 2 0.0017 0.0118 0.0118
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0427 0.0512
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0176 0.0381
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0025 0.004
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.035 0.3981 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0118 0.0118
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0032 0.0048
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0207 0.2323 0.3665
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0333 0.0776
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.004
Schistosoma mansoni pol-related 0.0009 0.0032 0.0038
Trypanosoma brucei aldo-keto reductase, putative 0.0009 0.0032 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Onchocerca volvulus 0.0009 0.0032 0.0213
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.008
Plasmodium falciparum aldehyde reductase, putative 0.0009 0.0032 0.0017
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Echinococcus granulosus chromobox protein 2 0.0011 0.0051 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0176 0.0278
Trichomonas vaginalis glutaminase, putative 0.0553 0.6337 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0349 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0363 0.057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0533 0.1284
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0128 0.026
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0128 0.026
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0032 0.0048
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0787 0.2201
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1663 0.414
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0025 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0396 0.0623
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0176 0.0239
Loa Loa (eye worm) hypothetical protein 0.0077 0.0821 0.1296
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0333 0.0776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0787 0.1207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0323 0.0753
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0176 0.0381
Onchocerca volvulus Huntingtin homolog 0.0136 0.1502 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0176 0.0278
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0323 0.0753
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0787 0.1207
Giardia lamblia Aldose reductase 0.0009 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0074 0.0787 0.1242
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0025 0.0025
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0176 0.0381
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.035 0.3981 1
Echinococcus granulosus hypothetical protein 0.0009 0.0032 0.0038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.025 0.0392
Brugia malayi MH2 domain containing protein 0.0008 0.002 0.0032
Schistosoma mansoni intermediate filament proteins 0.0028 0.0251 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0787 0.1242
Echinococcus granulosus transcription factor Dp 1 0.012 0.1312 0.1574
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0333 0.0776
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0171 0.0369
Schistosoma mansoni pyruvate kinase 0.0018 0.0128 0.0154
Onchocerca volvulus 0.0009 0.0032 0.0213
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0025 0.0031
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0569 0.1373
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0333 0.0776
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0171 0.0268
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0333 0.0776
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0171 0.0369
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.035 0.3981 1
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0025 0.0025
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0032 0.0017
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0349 0.0817
Echinococcus multilocularis musashi 0.0028 0.0251 0.0251
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0176 0.0381
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0025 0.0031
Echinococcus multilocularis lamin 0.0028 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.004
Echinococcus multilocularis pyruvate kinase 0.0035 0.0323 0.0323
Brugia malayi beta-lactamase family protein 0.0035 0.0333 0.0525
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0708 0.1115
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0787 0.1207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.013 0.0203
Brugia malayi Tyrosine-protein kinase abl-1 0.0083 0.0888 0.1401
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.013 0.0203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0088 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Trichomonas vaginalis hypothetical protein 0.0011 0.0051 0.0078
Echinococcus multilocularis smad 0.0008 0.002 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0009 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0333 0.0776
Echinococcus multilocularis aldo keto reductase 0.0009 0.0032 0.0032
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0032 0.0048
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.035 0.3981 0.6282
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0787 0.1926
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0071 0.0085
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Giardia lamblia Aldose reductase 0.0009 0.0032 0.0019
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0025 0.0031
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.035 0.3981 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0349 0.0817
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0118 0.0187
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0171 0.0205
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0176 0.0276
Echinococcus multilocularis pyruvate kinase 0.0018 0.0128 0.0128
Toxoplasma gondii aldo-keto reductase 0.0009 0.0032 0.0017
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0323 0.0508
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0025 0.0031
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0323 0.0753
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0333 0.0776
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.013 0.0203
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0032 0.0038
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0051 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0427 0.0512
Echinococcus granulosus lamin 0.0028 0.0251 0.0301
Echinococcus multilocularis pyruvate kinase 0.0018 0.0128 0.0128
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0051 0.0061
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0025 0.0037
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0051 0.0065
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.002 0.0024
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Onchocerca volvulus 0.003 0.0273 0.1815
Schistosoma mansoni hypothetical protein 0.0181 0.2028 0.2433
Echinococcus granulosus intermediate filament protein 0.0028 0.0251 0.0301
Brugia malayi Protein cec-1. 0.0011 0.0051 0.008
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0349 0.0418
Echinococcus granulosus pyruvate kinase 0.0018 0.0128 0.0154
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0093 0.0997 0.1573
Trypanosoma brucei unspecified product 0.0015 0.0094 0.0173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.013 0.0203
Onchocerca volvulus 0.0009 0.0032 0.0213
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0025 0.0031
Echinococcus granulosus cpg binding protein 0.0032 0.0292 0.0351
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0025 0.004
Schistosoma mansoni hypothetical protein 0.0372 0.4238 0.5084
Echinococcus granulosus chromobox protein 1 0.0068 0.0708 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Entamoeba histolytica aldose reductase, putative 0.0009 0.0032 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0234 0.0367
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0032 0.0017
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Brugia malayi hypothetical protein 0.0009 0.0025 0.004
Echinococcus granulosus lamin dm0 0.0028 0.0251 0.0301
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0176 0.0381
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0176 0.0381
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.035 0.3981 0.5
Onchocerca volvulus 0.0012 0.0059 0.039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0333 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.0333 0.0525
Loa Loa (eye worm) hypothetical protein 0.0056 0.0569 0.0897
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0333 0.0522
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0176 0.0278
Leishmania major pyruvate kinase 0.0035 0.0323 0.0753
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0025 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0051 0.0078
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0349 0.0817
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0323 0.051
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0071 0.0112
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0708 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Brugia malayi MH2 domain containing protein 0.0008 0.002 0.0032
Brugia malayi MH1 domain containing protein 0.0008 0.002 0.0032
Brugia malayi Importin beta-1 subunit 0.0035 0.0327 0.0515
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.025 0.0392
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0176 0.0239
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0118 0.0118
Mycobacterium ulcerans beta-lactamase 0.0035 0.0333 0.0487
Echinococcus granulosus tyrosine protein kinase ABL1 0.0204 0.2291 0.2749
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0171 0.0369
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0025 0.0037
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0051 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0094 0.0173
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0051 0.0078
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0207 0.2323 0.2786
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0171 0.0171
Mycobacterium ulcerans oxidoreductase 0.0009 0.0032 0.001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0176 0.0239
Loa Loa (eye worm) pyruvate kinase 0.0007 0.0007 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0234 0.0367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1024 0.1228
Echinococcus multilocularis chromobox protein 1 0.0068 0.0708 0.0708
Schistosoma mansoni potassium channel beta 0.0009 0.0032 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0333 0.0776
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0171 0.0369
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0032 0.0051
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0176 0.0239
Loa Loa (eye worm) hypothetical protein 0.0056 0.0569 0.0897
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0569 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0176 0.0278
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Brugia malayi RNA, U transporter 1 0.0099 0.1072 0.1692
Echinococcus granulosus Chromo domain 0.0011 0.0051 0.0061
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0176 0.0381
Mycobacterium ulcerans glutaminase 0.0553 0.6337 1
Brugia malayi pyruvate kinase 0.0007 0.0007 0.0011
Onchocerca volvulus 0.0028 0.0251 0.1672
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0142
Echinococcus multilocularis chromobox protein 2 0.0011 0.0051 0.0051
Schistosoma mansoni Smad4 0.0008 0.002 0.0024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.025 0.0568
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0349 0.0817
Echinococcus granulosus dna polymerase kappa 0.0021 0.0171 0.0205
Echinococcus multilocularis chromobox protein 1 0.0068 0.0708 0.0708
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.3486 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0333 0.0776
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0176 0.0239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1024 0.1616
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0136 0.1507 0.2376
Brugia malayi beta-lactamase 0.0035 0.0333 0.0525
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0323 0.0508
Schistosoma mansoni pyruvate kinase 0.0035 0.0323 0.0388
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0323 0.0753
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0025 0.0037
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2593 0.4092
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0025 0.0037
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0032 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0323 0.051
Onchocerca volvulus 0.0009 0.0032 0.0213
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0051 0.0065
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0333 0.0776
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0176 0.0239
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0207 0.2323 0.5807
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0032 0.0048
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0025 0.004
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0009 0.0032 0.0017
Loa Loa (eye worm) oxidoreductase 0.0009 0.0032 0.0051
Brugia malayi CXXC zinc finger family protein 0.003 0.0273 0.043
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0051 0.0074
Schistosoma mansoni glutaminase 0.0553 0.6337 0.7602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3486 0.5499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0542 0.0855
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0346 0.0546
Onchocerca volvulus 0.0022 0.0176 0.1174
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0323 0.0753
Loa Loa (eye worm) hypothetical protein 0.0028 0.0251 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Trypanosoma brucei prostaglandin f synthase 0.0009 0.0032 0.0017
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0323 0.2152
Loa Loa (eye worm) TK/ABL protein kinase 0.0204 0.2291 0.3616
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0787 0.1926
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.0118
Loa Loa (eye worm) oxidoreductase 0.0022 0.0176 0.0278
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0333 0.0522
Entamoeba histolytica hypothetical protein 0.0043 0.0427 0.116
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0118 0.0187
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0349 0.0817
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0349 0.0817
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.035 0.3981 0.6267
Onchocerca volvulus 0.0009 0.0032 0.0213
Plasmodium falciparum dihydroorotate dehydrogenase 0.035 0.3981 1
Schistosoma mansoni hypothetical protein 0.0036 0.0346 0.0415
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0171 0.027
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0176 0.0278
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0051 0.0078
Schistosoma mansoni eyes absent homolog 0.0093 0.0997 0.1196
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0056 0.0569 0.0897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0051 0.0078
Loa Loa (eye worm) helicase 0.0011 0.0051 0.008
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0207 0.2323 0.3665
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0032 0.0048
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0176 0.0381
Plasmodium vivax aldehyde reductase, putative 0.0009 0.0032 0.0017
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0207 0.2323 0.5807
Echinococcus granulosus importin subunit beta 1 0.0035 0.0327 0.0392
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0787 0.1242
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0171 0.0231
Mycobacterium ulcerans hypothetical protein 0.0074 0.0787 0.1207
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0024
Echinococcus granulosus Smad4 0.0008 0.002 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0333 0.0776
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0025 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0542 0.0855
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0032 0.0048
Loa Loa (eye worm) oxidoreductase 0.0009 0.0032 0.0051
Schistosoma mansoni lamin 0.0028 0.0251 0.0301
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0032 0.0032
Echinococcus granulosus aldo keto reductase 0.0009 0.0032 0.0038
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0025 0.0025
Onchocerca volvulus 0.0011 0.0051 0.0339
Plasmodium vivax importin-beta 2, putative 0.0035 0.0327 0.0762
Loa Loa (eye worm) hypothetical protein 0.0022 0.0176 0.0278
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0176 0.0381
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0333 0.0525
Brugia malayi pyruvate kinase, muscle isozyme 0.0007 0.0007 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0029 0.0046
Brugia malayi intermediate filament protein 0.0028 0.0251 0.0396
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0032 0.0048
Onchocerca volvulus 0.0009 0.0032 0.0213
Schistosoma mansoni chromobox protein 0.0068 0.0708 0.0849
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0171 0.0421
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0787 0.2201
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0251 0.0396
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0032 0.0038
Echinococcus multilocularis cpg binding protein 0.0032 0.0292 0.0292
Echinococcus multilocularis aldo keto reductase 0.0009 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1024 0.1228
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0323 0.051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0176 0.0381

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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