Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Nischarin homolog | 0.0202 | 0.6523 | 0.9966 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0202 | 0.6523 | 0.9966 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.7366 | 0.8007 |
Echinococcus granulosus | geminin | 0.0165 | 0.5066 | 0.7547 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5066 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0791 | 0.1178 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0271 | 0.92 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0203 | 0.6545 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0203 | 0.6545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.6545 | 1 |
Echinococcus multilocularis | nischarin | 0.0207 | 0.6713 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.6523 | 0.9966 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0791 | 0.1561 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | nischarin | 0.0207 | 0.6713 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0791 | 0.1178 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5066 | 0.7547 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0791 | 0.1561 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0791 | 0.1561 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5066 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0291 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0791 | 0.1178 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0791 | 0.1208 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0791 | 0.1178 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0791 | 0.1208 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.