Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0816 | 0.1143 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0816 | 0.0695 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0472 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.106 | 0.1143 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0491 | 0.0612 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0753 | 0.1034 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0287 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0816 | 0.088 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0149 | 0.0161 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0472 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0379 | 0.0239 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.6838 | 0.7371 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0174 | 0.0187 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0753 | 0.1034 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0379 | 0.0239 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0816 | 0.1168 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.014 | 0.4403 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3967 | 0.3977 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0149 | 0.3163 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.6838 | 0.7371 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.3553 | 0.383 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0149 | 0.0161 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0182 | 0.5988 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0149 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.106 | 0.1143 |
Brugia malayi | RNA binding protein | 0.0129 | 0.3967 | 0.4277 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0753 | 0.0629 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.106 | 0.1584 |
Loa Loa (eye worm) | RNA binding protein | 0.0129 | 0.3967 | 0.4277 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0753 | 0.0811 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 0.9276 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0149 | 0.3163 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0816 | 0.088 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0174 | 0.0042 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0149 | 0.0028 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 0.9276 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0281 | 0.9749 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.1898 | 0.1821 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3967 | 0.3977 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.2283 | 0.4608 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.3553 | 0.383 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.2283 | 0.4608 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0174 | 0.0187 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.2283 | 0.4608 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0472 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.2633 | 0.4269 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0174 | 0.007 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.0816 | 0.1143 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 0.9276 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.106 | 0.156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3967 | 0.3977 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.3553 | 0.383 |
Onchocerca volvulus | 0.0046 | 0.0816 | 0.0859 | |
Echinococcus granulosus | peregrin | 0.0029 | 0.0149 | 0.0028 |
Onchocerca volvulus | 0.0233 | 0.7913 | 1 | |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.106 | 0.1143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3967 | 0.3977 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.0816 | 0.1168 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0753 | 0.0629 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.2643 | 0.5524 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0816 | 0.0859 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0753 | 0.1059 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0472 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.2283 | 0.4608 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.2643 | 0.1698 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0491 | 0.0585 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0174 | 0.0025 |
Loa Loa (eye worm) | TAR-binding protein | 0.0129 | 0.3967 | 0.4277 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0379 | 0.0408 |
Onchocerca volvulus | 0.0029 | 0.0174 | 0.0031 | |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0287 | 1 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0149 | 0.0161 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.1311 | 0.1414 |
Brugia malayi | TAR-binding protein | 0.0129 | 0.3967 | 0.4277 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0472 | 0.0509 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0472 | 0.0509 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0174 | 0.0042 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0472 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0577 | 0.0758 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0472 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0174 | 0.0025 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0379 | 0.0393 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0287 | 1 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0816 | 0.0695 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0174 | 0.368 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0753 | 0.1059 |
Echinococcus multilocularis | tar DNA binding protein | 0.0129 | 0.3967 | 0.6539 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.2633 | 0.4253 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 0.9276 | 0.6534 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0929 | 0.1001 |
Schistosoma mansoni | glutaminase | 0.0268 | 0.9276 | 0.9508 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0816 | 0.0695 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0472 | 0.0509 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.2633 | 0.2838 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0472 | 0.0509 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.2643 | 0.5524 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0753 | 0.0811 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0816 | 0.088 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0129 | 0.3967 | 0.4277 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0174 | 0.0025 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0379 | 0.0421 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.2643 | 0.5524 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.106 | 0.156 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0472 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0753 | 0.0629 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0816 | 0.088 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0379 | 0.0408 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0174 | 0.368 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0182 | 0.5988 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.2283 | 0.4608 |
Echinococcus granulosus | tar DNA binding protein | 0.0129 | 0.3967 | 0.6549 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3967 | 0.3977 |
Brugia malayi | glutaminase DH11.1 | 0.0268 | 0.9276 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.106 | 0.1584 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0174 | 0.0025 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0577 | 0.0732 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0149 | 0.3163 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0129 | 0.3967 | 0.4277 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.2283 | 0.4608 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.106 | 0.0949 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.014 | 0.4403 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0149 | 0.3163 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0472 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.