Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0076 | 0.4313 | 0.4313 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4313 | 0.4313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4313 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4313 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1044 | 0.2421 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1044 | 0.1044 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1343 | 0.3114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4313 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1044 | 0.2421 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4313 | 0.4313 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1044 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2944 | 0.2944 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4313 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1044 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4313 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1044 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4313 | 0.4313 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2944 | 0.2944 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4313 | 0.4313 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1044 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1044 | 0.2421 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2944 | 0.2944 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4313 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4313 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1343 | 0.1343 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4313 | 0.4313 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2944 | 0.2944 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.