Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.2512 | 0.3862 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2185 | 0.3066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2185 | 0.3066 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.6506 | 0.9131 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2185 | 0.3066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2185 | 0.3066 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2185 | 0.3358 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.7125 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.6506 | 0.9131 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.2512 | 0.3526 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0055 | 0.2175 | 0.3343 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.6506 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.3526 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2185 | 0.3066 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2185 | 0.2185 |
Schistosoma mansoni | lipoxygenase | 0.0055 | 0.2175 | 0.3052 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.7125 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2185 | 0.3358 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.3526 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.2512 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2185 | 0.2185 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.7125 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2512 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0055 | 0.2175 | 0.3052 |
Onchocerca volvulus | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.