Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0153 | 0.6617 | 0.6617 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0153 | 0.6617 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0153 | 0.6617 | 0.6617 |
Brugia malayi | Cytochrome P450 family protein | 0.0153 | 0.6617 | 0.6617 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0153 | 0.6617 | 0.6617 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0153 | 0.6617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1627 | 0.1627 |
Trypanosoma brucei | cytochrome P450, putative | 0.0153 | 0.6617 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0153 | 0.6617 | 0.6617 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0153 | 0.6617 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0153 | 0.6617 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.