Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3075 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0084 | 0.1065 | 0.1291 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0526 | 0.0526 |
Brugia malayi | hypothetical protein | 0.0117 | 0.1668 | 0.1668 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0241 | 0.3919 | 0.3674 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0226 | 0.3649 | 0.3444 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3075 | 0.5 |
Brugia malayi | hypothetical protein | 0.0084 | 0.1065 | 0.1065 |
Echinococcus granulosus | presenilin | 0.0241 | 0.3919 | 0.3723 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0241 | 0.3919 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0241 | 0.3919 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0241 | 0.3919 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0575 | 1 | 1 |
Onchocerca volvulus | 0.0195 | 0.3075 | 0.5 | |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.3075 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0315 | 0.0002 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0226 | 0.3649 | 0.3649 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0315 | 0.0315 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0224 | 0.3608 | 0.9205 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0226 | 0.3649 | 0.3444 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0315 | 0.0002 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3075 | 0.7846 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.0117 | 0.1668 | 0.3841 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0224 | 0.3608 | 0.9205 |
Echinococcus multilocularis | Nicastrin | 0.0117 | 0.1668 | 0.1398 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0575 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.3075 | 0.5 |
Echinococcus multilocularis | presenilin | 0.0241 | 0.3919 | 0.3723 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0241 | 0.3919 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0241 | 0.3919 | 1 |
Trypanosoma brucei | Nicastrin, putative | 0.0043 | 0.0313 | 0.08 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0068 | 0.0767 | 0.1958 |
Brugia malayi | hypothetical protein | 0.0117 | 0.1668 | 0.1668 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.3075 | 0.5 |
Echinococcus multilocularis | Nicastrin | 0.0117 | 0.1668 | 0.1398 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.3075 | 0.2851 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0575 | 1 | 1 |
Brugia malayi | Presenilin family protein | 0.0241 | 0.3919 | 0.3919 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1668 | 0.1668 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0084 | 0.1065 | 0.1065 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0241 | 0.3919 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0315 | 0.0315 |
Brugia malayi | hypothetical protein | 0.0084 | 0.1065 | 0.1065 |
Echinococcus granulosus | Nicastrin | 0.0117 | 0.1668 | 0.1398 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 0.0767 | 0.1958 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0575 | 1 | 1 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0084 | 0.1065 | 0.1065 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3075 | 0.7846 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0241 | 0.3919 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3075 | 0.7846 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.3075 | 0.3075 |
Brugia malayi | hypothetical protein | 0.0093 | 0.1215 | 0.1215 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.1668 | 0.1332 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.1215 | 0.2602 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0224 | 0.3608 | 0.9205 |
Trypanosoma cruzi | Nicastrin, putative | 0.0043 | 0.0313 | 0.08 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.3075 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0093 | 0.1215 | 0.3099 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0211 | 0.0211 |
Brugia malayi | Presenilin spe-4 | 0.0084 | 0.1065 | 0.1065 |
Brugia malayi | Presenilin spe-4 | 0.0084 | 0.1065 | 0.1065 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.3075 | 0.3075 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0226 | 0.3649 | 0.3649 |
Brugia malayi | hypothetical protein | 0.0084 | 0.1065 | 0.1065 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.3075 | 0.2851 |
Brugia malayi | Presenilin spe-4 | 0.0084 | 0.1065 | 0.1065 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3075 | 0.2796 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.0117 | 0.1668 | 0.3841 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0241 | 0.3919 | 1 |
Trypanosoma cruzi | Nicastrin, putative | 0.0043 | 0.0313 | 0.08 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.35 uM | In vitro inhibitory activity against thymidylate synthase from L1210 mouse leukemia cells | ChEMBL. | 1495009 |
IC50 (binding) | = 0.35 uM | In vitro inhibitory activity against thymidylate synthase from L1210 mouse leukemia cells | ChEMBL. | 1495009 |
IC50 (functional) | = 4 uM | In vitro inhibition of L1210 mouse leukemia cell growth in culture | ChEMBL. | 1495009 |
IC50 (functional) | = 4 uM | In vitro inhibition of L1210 mouse leukemia cell growth in culture | ChEMBL. | 1495009 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 1495009 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.