Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0621 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2389 | 0.2389 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3472 | 0.3472 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0621 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0621 | 0.1789 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0621 | 0.0621 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2389 | 0.2389 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2389 | 0.688 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2389 | 0.2389 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2389 | 0.2389 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2389 | 0.688 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0621 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2389 | 0.2389 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0621 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0621 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0621 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0621 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0621 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0621 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2389 | 0.2389 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3472 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0621 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3472 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3472 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0621 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3472 | 0.3472 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0621 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0621 | 0.0621 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0621 | 0.0621 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3472 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0621 | 0.0621 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3472 | 0.3472 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0621 | 0.1789 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0621 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2389 | 0.2389 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3472 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0621 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3472 | 0.3472 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3472 | 0.3472 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0621 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3472 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3472 | 0.3472 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3472 | 0.3472 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1458 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.