Detailed information for compound 1539001

Basic information

Technical information
  • TDR Targets ID: 1539001
  • Name: 61295-73-6
  • MW: 345.486 | Formula: C16H19N5S2
  • H donors: 5 H acceptors: 0 LogP: 4.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NNc1ccccc1)NNC(=S)Nc1ccc(c(c1)C)C
  • InChi: 1S/C16H19N5S2/c1-11-8-9-14(10-12(11)2)17-15(22)19-21-16(23)20-18-13-6-4-3-5-7-13/h3-10,18H,1-2H3,(H2,17,19,22)(H2,20,21,23)
  • InChiKey: WVSPHRHPGDIFKT-UHFFFAOYSA-N  

Network

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Synonyms

  • NSC146569

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0023 0.0037
Brugia malayi MH2 domain containing protein 0.0017 0.0021 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0023 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0028 0.0047
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0386 0.3809
Echinococcus granulosus dna polymerase kappa 0.002 0.0038 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0135 0.0261
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.007 0.0349 0.0485
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.0879 0.0875
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0107 0.0574 0.0852
Echinococcus multilocularis GPCR, family 2 0.0019 0.0033 0.0029
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0182 0.1736
Leishmania major cathepsin L-like protease 0.0034 0.0124 0.0934
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0174 0.0993 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Brugia malayi MH2 domain containing protein 0.0251 0.1466 0.1816
Mycobacterium leprae conserved hypothetical protein 0.007 0.0349 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0028 0.0034
Echinococcus granulosus Smad4 0.0017 0.0021 0.0034
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.003 0.0012
Mycobacterium ulcerans polyketide synthase 0.0738 0.4476 0.705
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0043 0.0182 0.0229
Plasmodium vivax vivapain-2 0.0034 0.0124 0.104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0288 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0386 0.3122
Mycobacterium ulcerans fatty acid synthase Fas 0.0218 0.1264 0.1948
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0121 0.1008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Entamoeba histolytica hypothetical protein 0.0025 0.0072 0.1362
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0038 0.0382
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0559 0.337 0.5313
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0055 0.0101
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0044 0.0187 0.178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0033 0.0042
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0024 0.0016
Echinococcus granulosus cathepsin L 0.0017 0.0023 0.0037
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0568 0.3427 0.5384
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0324 0.032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0028 0.003
Onchocerca volvulus 0.0043 0.0182 0.0203
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0344 0.068
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0014 0.0009
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Onchocerca volvulus 0.1209 0.7389 0.965
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0187 0.0365
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0023 0.0111
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0052 0.0238 0.0329
Loa Loa (eye worm) acyl carrier protein 0.0319 0.189 0.2647
Echinococcus granulosus smad 0.0017 0.0021 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0033 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.007 0.0349 0.0495
Mycobacterium ulcerans Type I modular polyketide synthase 0.0695 0.4209 0.6627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Leishmania major protein kinase, putative 0.002 0.0037 0.0212
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.003 0.018
Schistosoma mansoni Smad4 0.0017 0.0021 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0649 0.3927 0.5507
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0695 0.4209 0.6627
Mycobacterium ulcerans dehydrogenase 0.0043 0.0182 0.0229
Mycobacterium tuberculosis Conserved protein 0.0209 0.1209 0.186
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0024 0.002
Echinococcus multilocularis musashi 0.0027 0.008 0.0076
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0043 0.0182 0.0229
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0043 0.0182 0.0229
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0386 0.0763
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0028 0.003
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0044 0.0187 0.0227
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0182 0.0178
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0182 0.1736
Schistosoma mansoni cpg binding protein 0.0061 0.0293 0.0578
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0043 0.0182 0.0229
Leishmania major zinc-binding dehydrogenase-like protein 0.0043 0.0182 0.1423
Onchocerca volvulus 0.0058 0.0273 0.0321
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0124 0.2782
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0285
Leishmania major hypothetical protein, conserved 0.0209 0.1209 1
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0142 0.0171
Schistosoma mansoni cpg binding protein 0.0058 0.0273 0.0537
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0121 0.1216
Onchocerca volvulus Putative alcohol dehydrogenase 0.0043 0.0182 0.0203
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0024 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Brugia malayi Cathepsin L-like precursor 0.0034 0.0124 0.0149
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0028 0.0047
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0043 0.0182 0.0229
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0386 0.0763
Brugia malayi AMP-binding enzyme family protein 0.0214 0.1236 0.153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.0182 0.0229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0046 0.006
Toxoplasma gondii exonuclease III APE 0.0021 0.0046 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0043 0.0182 0.0229
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0119 0.0144
Brugia malayi Cathepsin L-like precursor 0.0034 0.0124 0.0149
Schistosoma mansoni hypothetical protein 0.0534 0.3217 0.6428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.0349 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0028 0.003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0046 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0124 0.0934
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0386 0.3019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Leishmania major cathepsin L-like protease 0.0128 0.0709 0.5822
Echinococcus multilocularis cysteine protease 0.0034 0.0124 0.012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0121 0.0116
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0038 0.0382
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0028 0.0047
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.007 0.0349 0.0345
Schistosoma mansoni alcohol dehydrogenase 0.0043 0.0182 0.0356
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0386 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Brugia malayi hypothetical protein 0.0035 0.0135 0.0163
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0107 0.0574 0.0852
Brugia malayi AMP-binding enzyme family protein 0.0649 0.3927 0.4874
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.005 0.0391
Onchocerca volvulus 0.0034 0.0124 0.0126
Brugia malayi PAS domain containing protein 0.0016 0.0012 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.0058
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0649 0.3927 0.6178
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.0349 0.0495
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0344 0.0478
Mycobacterium ulcerans oxidoreductase 0.0043 0.0182 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0135 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0028 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Loa Loa (eye worm) ctsf protein 0.0034 0.0124 0.0169
Toxoplasma gondii type I fatty acid synthase, putative 0.0738 0.4476 1
Echinococcus granulosus AMP dependent ligase 0.007 0.0349 0.069
Leishmania major cathepsin L-like protease 0.0128 0.0709 0.5822
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0349 0.0495
Brugia malayi intermediate filament protein 0.0027 0.008 0.0095
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.007 0.0349 0.0495
Echinococcus multilocularis smad 0.0017 0.0021 0.0017
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.018
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0021 0.0017
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0043 0.0182 0.1836
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.003 0.0299
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0024 0.0029
Plasmodium falciparum acyl carrier protein 0.007 0.0349 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0451 0.2701 0.6013
Mycobacterium ulcerans quinone oxidoreductase 0.0043 0.0182 0.0229
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0028 0.0047
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0174 0.0993 0.8198
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0014 0.0019
Echinococcus granulosus acyl carrier protein mitochondrial 0.007 0.0349 0.069
Schistosoma mansoni hypothetical protein 0.0035 0.0135 0.0261
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0182 0.0229
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0695 0.4209 0.5224
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0386 0.0382
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0043 0.0182 0.0251
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0175 0.4199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0028 0.003
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1038 0.6333 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0028 0.003
Leishmania major acyl carrier protein, putative 0.007 0.0349 0.2818
Toxoplasma gondii cathepsin CPL 0.0034 0.0124 0.0223
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0023 0.0111
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0115 0.1153
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0043 0.0182 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.003 0.0051
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0038 0.0217
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.1089 0.1392
Onchocerca volvulus 0.0034 0.0124 0.0126
Onchocerca volvulus 0.0027 0.008 0.0069
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0324 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0028 0.0023
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0046 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0281 0.1652 0.2564
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0673 0.4078 0.6417
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0115 0.0856
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0182 0.0229
Onchocerca volvulus Protein cycle homolog 0.0037 0.0142 0.015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0182 0.0251
Schistosoma mansoni thyroid hormone receptor 0.0151 0.0848 0.1687
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0124 0.0239
Mycobacterium leprae Probable oxidireductase 0.0043 0.0182 0.0269
Schistosoma mansoni smad1 5 8 and 0.0017 0.0021 0.0034
Trypanosoma cruzi acyl transferase-like protein, putative 0.0044 0.0187 0.178
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Onchocerca volvulus 0.0052 0.0238 0.0275
Echinococcus granulosus geminin 0.0534 0.3217 0.6428
Echinococcus granulosus phd:f box containing protein 0.0018 0.0024 0.004
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.003 0.0036
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0386 0.3884
Schistosoma mansoni DNA polymerase eta 0.002 0.0038 0.0067
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0043 0.0182 0.0355
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0175 0.157
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0182 0.1836
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0349 0.8995
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0124 0.012
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.0349 0.0429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0257 0.0506
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.1328 0.1859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0257 0.0506
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0124 0.0149
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0169
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0121 0.0116
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0043 0.0182 0.0229
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.0555 0.5479
Echinococcus granulosus expressed protein 0.0033 0.0119 0.023
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0124 0.2782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Brugia malayi Cathepsin L-like precursor 0.0023 0.0055 0.0064
Onchocerca volvulus 0.0043 0.0182 0.0203
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0736 0.1463
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0021 0.0025
Onchocerca volvulus 0.0034 0.0124 0.0126
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0038 0.0382
Echinococcus multilocularis aryl hydrocarbon receptor 0.0052 0.0238 0.0234
Loa Loa (eye worm) intermediate filament protein 0.0027 0.008 0.0107
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0124 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0257 0.0506
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0021 0.0034
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0386 0.0382
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0038 0.0264
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.064 0.6401
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0072 0.0136
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0182 0.1736
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0135 0.0261
Schistosoma mansoni hypothetical protein 0.0133 0.0736 0.1463
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.018
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.0349 0.0495
Echinococcus granulosus cpg binding protein 0.0061 0.0293 0.0578
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.0879 0.175
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0028 0.0034
Trichomonas vaginalis rotamase, putative 0.0033 0.0119 0.0897
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0028 0.0047
Brugia malayi MH1 domain containing protein 0.0017 0.0021 0.0022
Onchocerca volvulus 0.0027 0.008 0.0069
Mycobacterium ulcerans thioesterase TesA 0.0579 0.3494 0.549
Leishmania major cathepsin L-like protease 0.0034 0.0124 0.0934
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0187 0.0365
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0187 0.0182
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0028 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0072 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Brugia malayi jmjC domain containing protein 0.0069 0.0344 0.0423
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0028 0.003
Onchocerca volvulus Fatty acid synthase homolog 0.1252 0.7656 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Loa Loa (eye worm) hypothetical protein 0.019 0.1089 0.1524
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0043 0.0182 0.4393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Brugia malayi nuclear hormone receptor 0.0018 0.0028 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0124 0.0239
Loa Loa (eye worm) hypothetical protein 0.006 0.0288 0.0399
Mycobacterium tuberculosis Probable thioesterase TesA 0.0579 0.3494 0.549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trypanosoma cruzi acyl transferase-like protein 0.0044 0.0187 0.178
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0028 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0038 0.0048
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0024 0.004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0121 0.1108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0119 0.0162
Brugia malayi MH2 domain containing protein 0.0017 0.0021 0.0022
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0386 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0072
Mycobacterium leprae Probable polyketide synthase Pks1 0.0738 0.4476 0.7062
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0174 0.0993 1
Schistosoma mansoni methyltransferase-related 0.0209 0.1209 0.241
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0174 0.0993 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0182 0.4393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0029
Schistosoma mansoni hypothetical protein 0.0041 0.017 0.0331
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.0233
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0084
Echinococcus multilocularis lamin dm0 0.0027 0.008 0.0076
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0024 0.0127
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0021 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.003 0.0299
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.0349 0.0495
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0738 0.4476 0.705
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0021 0.0034
Echinococcus granulosus NADH dehydrogenase 0.007 0.0349 0.069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0115 0.1045
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0351 0.2086 0.463
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0174 0.0993 0.1979
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0555 0.5479
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0285
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0539 0.5372
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0046 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0182 0.4393
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0038 0.0034
Mycobacterium ulcerans short-chain dehydrogenase 0.0047 0.0206 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0028 0.0023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0046 0.0042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0038 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0028 0.003
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0344 0.068
Schistosoma mansoni smad1 5 8 and 0.0017 0.0021 0.0034
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0273 0.0378
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.003 0.0183
Echinococcus granulosus cysteine protease 0.0017 0.0023 0.0037
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0459 0.2755 0.4316
Brugia malayi ecdysteroid receptor 0.0018 0.0028 0.003
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0182 0.1423
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.003 0.018
Leishmania major oxidoreductase-like protein 0.0043 0.0182 0.1423
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0043 0.0182 0.1438
Leishmania major oxidoreductase, putative 0.0043 0.0182 0.1423
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0499 0.3 0.4705
Loa Loa (eye worm) fibroinase 0.0034 0.0124 0.0169
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0182 0.1736
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.0465
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0121 0.0116
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0023 0.0111
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0142 0.0194
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0044 0.0187 0.1687
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0174 0.0993 0.2176
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0673 0.4078 0.6417
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0121 0.0164
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0024 0.004
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0174 0.0993 0.1229
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1038 0.6333 1
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0182 0.0229
Mycobacterium ulcerans oxidoreductase FadB5 0.0043 0.0182 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Mycobacterium ulcerans thioesterase 0.0579 0.3494 0.549
Trichomonas vaginalis rotamase, putative 0.0032 0.0115 0.0856
Schistosoma mansoni single-minded 0.0016 0.0012 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0038 0.0264
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0043 0.0182 0.0229
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0182 0.1736
Loa Loa (eye worm) hypothetical protein 0.0107 0.0574 0.0801
Loa Loa (eye worm) hypothetical protein 0.0389 0.2321 0.3253
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0025 0.0026
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0695 0.4209 0.664
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.008 0.0107
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0288 0.0353
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0084
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0695 0.4209 0.6627
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0182 0.1736
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0038 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0023 0.0091
Leishmania major cathepsin L-like protease 0.0034 0.0124 0.0934
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.007 0.0349 0.3201
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.007 0.0349 0.0429
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0065
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.003 0.0025
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0182 0.1423
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0695 0.4209 0.6627
Echinococcus granulosus GPCR family 2 0.0019 0.0033 0.0058
Schistosoma mansoni cpg binding protein 0.0061 0.0293 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0072 0.0504
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0038 0.0264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Brugia malayi MH1 domain containing protein 0.0017 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0029
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0024 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0214 0.1236 0.1903
Brugia malayi nuclear receptor NHR-88 0.0018 0.0028 0.003
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0182 0.1836
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.003 0.0051
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0738 0.4476 0.7062
Loa Loa (eye worm) cysteine protease 0.0034 0.0124 0.0169
Brugia malayi Cathepsin L-like precursor 0.0023 0.0055 0.0064
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0736 0.0731
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0043 0.0182 0.0229
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0107 0.0574 0.0889
Loa Loa (eye worm) hypothetical protein 0.0043 0.0182 0.0251
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0055 0.0885
Echinococcus multilocularis NADH dehydrogenase 0.007 0.0349 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0046 0.0139
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0024 0.004
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0199 0.0392
Mycobacterium ulcerans acyl carrier protein 0.007 0.0349 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.1209 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0199 0.1561
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0038 0.0217
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0038 0.0382
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0028 0.003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0124 0.0169
Brugia malayi Alcohol dehydrogenase class III 0.0043 0.0182 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0028 0.0047
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.003 0.0051
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0072 0.0615
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0024 0.002
Brugia malayi hypothetical protein 0.0037 0.0142 0.0171
Echinococcus granulosus aryl hydrocarbon receptor 0.0052 0.0238 0.0468
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0028 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0028 0.0034
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0021 0.0034
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.0349 0.0534
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0028 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0026 0.0022
Echinococcus multilocularis cysteine protease 0.0034 0.0124 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0124 0.104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0023 0.0231
Schistosoma mansoni intermediate filament proteins 0.0027 0.008 0.0152
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0028 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Echinococcus granulosus tumor protein p63 0.0356 0.2116 0.4225
Brugia malayi Cathepsin L-like precursor 0.0034 0.0124 0.0149
Entamoeba histolytica cysteine protease, putative 0.0034 0.0124 0.2782
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0386 0.0382
Mycobacterium ulcerans Type I modular polyketide synthase 0.0695 0.4209 0.6627
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0174 0.0993 0.1518
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0024 0.0029
Schistosoma mansoni zinc binding dehydrogenase 0.0043 0.0182 0.0356
Leishmania major hypothetical protein, conserved 0.0018 0.0024 0.0104
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.0879 0.1087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Mycobacterium tuberculosis Hypothetical protein 0.0209 0.1209 0.186
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.003 0.0051
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.003 0.0299
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.003 0.0148
Trypanosoma brucei unspecified product 0.002 0.0038 0.0382
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0182 0.0222
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.0848 0.0844
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Schistosoma mansoni smad 0.0017 0.0021 0.0034
Brugia malayi hypothetical protein 0.0052 0.0237 0.0289
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0115 0.1045
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0579 0.3494 0.5508
Brugia malayi Smad1 0.0017 0.0021 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0023 0.0024
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0174 0.0993 1
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0043 0.0182 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.1466 0.2052
Leishmania major DNA polymerase kappa, putative 0.002 0.0038 0.0217
Schistosoma mansoni thyroid hormone receptor 0.0151 0.0848 0.1687
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0386 0.3809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0182 0.0222
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.309
Mycobacterium ulcerans acyl carrier protein 0.007 0.0349 0.0495
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0072 0.0728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.024
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.1466 0.2052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0028 0.0047
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0072 0.0136
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0038 0.0042
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0182 0.1423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0257 0.0253
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0395 0.2357 0.3683
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0043 0.0182 0.0229
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0124 0.104
Loa Loa (eye worm) hypothetical protein 0.0052 0.0238 0.0328
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.0852 0.1696
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0174 0.0993 0.1389
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.003 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Mycobacterium ulcerans hypothetical protein 0.007 0.0349 0.0495
Echinococcus multilocularis dna polymerase eta 0.002 0.0038 0.0034
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0024 0.002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0386 0.3122
Leishmania major nuclear receptor binding factor-like protein 0.0043 0.0182 0.1423
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0349 0.0495
Loa Loa (eye worm) Smad1 0.0017 0.0021 0.0025
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0148
Echinococcus multilocularis cpg binding protein 0.0061 0.0293 0.0289
Brugia malayi Phosphopantetheine attachment site family protein 0.007 0.0349 0.0429
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0038 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0023 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0121 0.0145
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.003 0.0148
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0024 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.017 0.0965 0.1472
Schistosoma mansoni smad1 5 8 and 0.0017 0.0021 0.0034
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0046 0.0641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0124 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0028 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0115 0.0202
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.008 0.0095
Brugia malayi follicle stimulating hormone receptor 0.0229 0.1328 0.1645
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0182 0.1736
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0021 0.0017
Echinococcus multilocularis dna polymerase kappa 0.002 0.0038 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0257 0.0506
Mycobacterium ulcerans polyketide synthase MbtC 0.0174 0.0993 0.1518
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0182 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0344 0.068
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0182 0.0356
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0709 0.7102
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0028 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0045 0.004
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0182 0.0229
Brugia malayi hypothetical protein 0.0036 0.014 0.0169
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0121 0.0116
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0121 0.0216
Toxoplasma gondii acyl carrier protein ACP 0.007 0.0349 0.073
Loa Loa (eye worm) hypothetical protein 0.1167 0.7129 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0124 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0124 0.0239
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0257 0.0506
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0257 0.0315
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.309
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0182 0.1736
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0044 0.0187 0.1687
Onchocerca volvulus 0.0023 0.0055 0.0036
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0182 0.1423
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0043 0.0182 0.0229
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0174 0.0993 0.1518
Toxoplasma gondii acyl transferase domain-containing protein 0.0044 0.0187 0.0364
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0559 0.337 0.5294
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0121 0.0116
Brugia malayi Methyltransferase-like protein 4 0.0209 0.1209 0.1497
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0038 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Mycobacterium ulcerans polyketide synthase Pks9 0.0459 0.2755 0.4316
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.007 0.0349 0.0422
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0124 0.114
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0044 0.0187 0.1483
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0459 0.2755 0.4339
Onchocerca volvulus 0.0074 0.0373 0.0453
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0024 0.0127
Mycobacterium ulcerans oxidoreductase 0.0043 0.0182 0.0229
Echinococcus granulosus lamin 0.0027 0.008 0.0152
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0121 0.1108
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0107 0.0574 0.0852
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0043 0.0182 0.0269
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0238 0.0467
Plasmodium vivax acyl carrier protein, putative 0.007 0.0349 0.3364
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0174 0.0993 1
Schistosoma mansoni acyl carrier protein 0.007 0.0349 0.069
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.003 0.0188
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0738 0.4476 0.705
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0738 0.4476 0.705
Echinococcus multilocularis expressed protein 0.0033 0.0119 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0673 0.1338
Loa Loa (eye worm) hypothetical protein 0.0043 0.0182 0.0251
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.017 0.0207
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0038 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0028 0.0047
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.014 0.0169
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.007 0.0349 0.0495
Plasmodium vivax vivapain-2 0.0034 0.0124 0.104
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0121 0.0908
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0218 0.1264 0.1948
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0028 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0055 0.0359
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0124 0.012
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0349 0.0534
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0026
Echinococcus multilocularis AMP dependent ligase 0.007 0.0349 0.0345
Brugia malayi N-terminal motif family protein 0.019 0.1089 0.1348
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0028 0.003
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0121 0.1008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0121 0.0233
Plasmodium vivax JmjC domain containing protein 0.0018 0.0024 0.0016
Onchocerca volvulus 0.0649 0.3927 0.5112
Onchocerca volvulus 0.0034 0.0124 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0738 0.4476 0.7062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Echinococcus multilocularis cathepsin L 0.0017 0.0023 0.0019
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0386 0.0763
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0121 0.0233
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0028 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0028 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.003 0.0036
Onchocerca volvulus 0.0052 0.0237 0.0274
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.003 0.0188
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0072 0.0068
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0695 0.4209 0.664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0028 0.0034
Leishmania major cathepsin L-like protease 0.0034 0.0124 0.0934
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0026
Mycobacterium ulcerans Type I modular polyketide synthase 0.0695 0.4209 0.6627
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0709 0.7102
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0559 0.337 0.5294
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0386 0.0475
Leishmania major d-xylulose reductase, putative 0.0043 0.0182 0.1423
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0043 0.0182 0.0229
Echinococcus multilocularis Smad4 0.0017 0.0021 0.0017
Schistosoma mansoni lamin 0.0027 0.008 0.0152
Onchocerca volvulus 0.0034 0.0124 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0119 0.0897
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.007 0.0349 0.0495
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0076 0.0386 0.0536
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0709 0.7102
Schistosoma mansoni lamin 0.0027 0.008 0.0152
Schistosoma mansoni hypothetical protein 0.0823 0.5002 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0191
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0046 0.0013
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.007 0.0349 0.3437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Schistosoma mansoni hypothetical protein 0.0534 0.3217 0.6428
Echinococcus granulosus lamin dm0 0.0027 0.008 0.0152
Schistosoma mansoni rotamase 0.0033 0.0119 0.023
Echinococcus granulosus dna polymerase eta 0.002 0.0038 0.0067
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0695 0.4209 0.6627
Giardia lamblia Methyltransferase like 2 0.0209 0.1209 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0038 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0023 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0182 0.0251
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.4124 0.8243
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0026 0.0031
Echinococcus granulosus cathepsin l1 0.0034 0.0124 0.0239
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0121 0.0132
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0174 0.0993 1
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0121 0.0216
Leishmania major quinone oxidoreductase, putative 0.0043 0.0182 0.1423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0028 0.0034
Onchocerca volvulus 0.0034 0.0124 0.0126
Leishmania major cathepsin L-like protease 0.0128 0.0709 0.5822
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0187 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0033 0.0037
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0043 0.0182 0.0229
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0028 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.0348
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0014 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0028 0.0047
Loa Loa (eye worm) acetyltransferase 0.0156 0.0879 0.1228
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0026 0.0044
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0044 0.0187 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0174 0.0993 0.1979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0023 0.0037
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.0349 0.0495
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0107 0.0574 0.0852
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0174 0.0993 1
Brugia malayi isocitrate dehydrogenase 0.0033 0.0121 0.0145
Chlamydia trachomatis acyl carrier protein 0.007 0.0349 0.3437
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0738 0.4476 0.705
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.003 0.018
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.003 0.0148
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0124 0.104
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0055 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0028 0.0023
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0124 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0024 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.0029
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0024 0.002
Echinococcus multilocularis tumor protein p63 0.0356 0.2116 0.2113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Giardia lamblia DINP protein human, muc B family 0.002 0.0038 0.007
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0386 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0032
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0386 0.3122
Toxoplasma gondii type I fatty acid synthase, putative 0.0494 0.2972 0.6621
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.309
Echinococcus granulosus microtubule associated protein 2 0.0681 0.4124 0.8243
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.0709 0.7102
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0038 0.0217
Loa Loa (eye worm) hypothetical protein 0.0027 0.008 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0028 0.0023
Loa Loa (eye worm) fatty acid synthase 0.0685 0.4152 0.5822
Brugia malayi jmjC domain containing protein 0.0066 0.0324 0.0398
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0028 0.0047
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.003 0.0025
Toxoplasma gondii type I fatty acid synthase 0.0107 0.0574 0.1235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0124 0.0934
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0257 0.0253
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0327
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0028 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0023 0.0091
Loa Loa (eye worm) hypothetical protein 0.0107 0.0574 0.0801
Mycobacterium ulcerans polyketide synthase Pks13 0.1038 0.6333 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.0349 0.0495
Schistosoma mansoni jumonji domain containing protein 0.0066 0.0324 0.0639
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0239 0.1392 0.215
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0187 0.0365
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0124 0.0239
Echinococcus granulosus dnaJ subfamily B 0.0823 0.5002 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0349 0.8995
Brugia malayi Cathepsin L-like precursor 0.0034 0.0124 0.0149
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0199 0.1561
Mycobacterium ulcerans quinone oxidoreductase 0.0043 0.0182 0.0229
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0043 0.0182 0.0229
Mycobacterium ulcerans polyketide synthase 0.0695 0.4209 0.6627
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0115 0.2525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0055 0.0359
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0257
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.007 0.0349 0.3517
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0043 0.0182 0.0269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0103
Mycobacterium leprae Polyketide synthase Pks13 0.1038 0.6333 1
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0182 0.1736
Echinococcus multilocularis dnaJ subfamily B 0.0823 0.5002 0.5
Echinococcus granulosus intermediate filament protein 0.0027 0.008 0.0152
Echinococcus multilocularis geminin 0.0534 0.3217 0.3214
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0046 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.4124 0.4122
Toxoplasma gondii quinone oxidoreductase, putative 0.0043 0.0182 0.0355
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0124 0.0126
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0124 0.012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0028 0.0047
Echinococcus multilocularis lamin 0.0027 0.008 0.0076
Leishmania major hypothetical protein, conserved 0.0044 0.0187 0.1459
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0386 0.3122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0124 0.0934
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0023 0.0231
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0738 0.4476 0.705
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0121 0.1216
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0142 0.0275
Brugia malayi CXXC zinc finger family protein 0.0058 0.0273 0.0334
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0174 0.0993 1
Leishmania major cathepsin L-like protease 0.0034 0.0124 0.0934
Leishmania major DNA polymerase eta, putative 0.002 0.0038 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Schistosoma mansoni coup transcription factor 0.0018 0.0028 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0028 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0012
Treponema pallidum acyl carrier protein 0.007 0.0349 1
Onchocerca volvulus 0.0034 0.0124 0.0126
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0028 0.0047
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0257 0.0356
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0024 0.0029
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0038 0.0042
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0028 0.0047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0382
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0175 0.1234
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0142 0.0171
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0043 0.0182 0.0269
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0218 0.1264 0.1981
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0046 0.0285
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0023 0.0037
Schistosoma mansoni hypothetical protein 0.007 0.0349 0.069
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.0349 0.0495
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0045 0.0081
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0199 0.0392
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0349 0.0495
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0028 0.0047
Loa Loa (eye worm) acyl carrier protein 0.007 0.0349 0.0485
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0616 0.1329
Leishmania major zinc binding dehydrogenase-like protein 0.0043 0.0182 0.1423
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1317 0.8054 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0024 0.004
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0072 0.0108
Mycobacterium ulcerans polyketide synthase MbtD 0.0214 0.1236 0.1903
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0288 0.0399
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0124 0.0934
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0199 0.1813
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0028 0.003
Brugia malayi Cathepsin L-like precursor 0.0034 0.0124 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0148
Brugia malayi cathepsin L-like precursor 0.0023 0.0055 0.0064
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0148
Mycobacterium ulcerans quinone reductase Qor 0.0043 0.0182 0.0229
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0043 0.0182 0.0229
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0028 0.0047
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0124 0.012
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0324 0.0639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0709 0.7138
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.007 0.0349 0.0495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0028 0.003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.0349 0.0495
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0058
Brugia malayi steroid hormone receptor 0.0018 0.0028 0.003
Echinococcus granulosus cathepsin l1 0.0023 0.0055 0.0101
Trypanosoma brucei acyl transferase-like protein 0.0044 0.0187 0.1879
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0191
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0199 0.0389

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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