Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | nuclear receptor subfamily 1, group H, member 4 | 476 aa | 402 aa | 28.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.004 | 0.0398 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.004 | 0.0398 | 0.0398 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.1549 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1549 | 0.1549 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0375 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.301 | 0.301 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.1549 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.301 | 0.301 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.301 | 0.301 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.301 | 0.301 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.029 | 0.029 |
Brugia malayi | Peptidase family M1 containing protein | 0.004 | 0.0398 | 0.0137 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.004 | 0.0398 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.004 | 0.0398 | 0.0398 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0375 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.004 | 0.0398 | 0.0137 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0726 | 0.0474 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0398 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.004 | 0.0398 | 0.2568 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0111 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0375 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.2797 | 0.2797 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.301 | 0.301 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.1549 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.1549 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.004 | 0.0398 | 0.0398 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0398 |
Trypanosoma cruzi | aminopeptidase, putative | 0.004 | 0.0398 | 0.2568 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.1549 | 1 |
Onchocerca volvulus | 0.004 | 0.0398 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.301 | 0.2802 |
Echinococcus granulosus | aminopeptidase N | 0.004 | 0.0398 | 0.0111 |
Brugia malayi | hypothetical protein | 0.008 | 0.1549 | 0.1319 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0264 | 0.0264 |
Onchocerca volvulus | 0.004 | 0.0398 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0726 | 0.0726 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.004 | 0.0398 | 0.2568 |
Brugia malayi | RNA binding protein | 0.0131 | 0.301 | 0.2821 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.004 | 0.0398 | 0.0398 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.1549 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0111 |
Brugia malayi | hypothetical protein | 0.004 | 0.0398 | 0.0137 |
Entamoeba histolytica | aminopeptidase, putative | 0.004 | 0.0398 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.004 | 0.0398 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.301 | 0.301 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.1549 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.004 | 0.0398 | 0.0398 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.301 | 0.301 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0375 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0375 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.301 | 0.301 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0726 | 0.0474 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.2797 | 0.2797 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.1549 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0036 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0726 | 0.0726 |
Brugia malayi | hypothetical protein | 0.0051 | 0.074 | 0.0489 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.301 | 0.2821 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0398 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0375 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.301 | 0.301 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0264 | 0.0264 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.301 | 0.2821 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.2797 | 0.2602 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.004 | 0.0398 | 0.0111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0079 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of farnesoid X receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.