TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 479.654 | Formula: C29H41N3O3
H donors: 1 H acceptors: 3 LogP: 3.68 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC1CC(=C(N(C1=O)CCC1=CCCCC1)C)C(=O)N(C)C)NCCCCc1ccccc1
InChi: 1S/C29H41N3O3/c1-22-26(29(35)31(2)3)20-25(28(34)32(22)19-17-24-14-8-5-9-15-24)21-27(33)30-18-11-10-16-23-12-6-4-7-13-23/h4,6-7,12-14,25H,5,8-11,15-21H2,1-3H3,(H,30,33)
InChiKey: WAIPVMAFVCWOOA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed), eta	Starlite/ChEMBL	No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	ImpB/MucB/SamB family protein	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus granulosus	dna polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Schistosoma mansoni	DNA polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania infantum	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma brucei	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania mexicana	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Candida albicans	similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions	Get druggable targets OG5_128521	All targets in OG5_128521
Cryptosporidium parvum	DinB/family X-type DNA polymerase	Get druggable targets OG5_128521	All targets in OG5_128521
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania infantum	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania major	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania braziliensis	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128521	All targets in OG5_128521
Neospora caninum	Pc21g17280 protein, related	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania mexicana		Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania major	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma cruzi	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K03509 DNA polymerase eta subunit, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma cruzi	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Candida albicans	similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K03509 DNA polymerase eta subunit, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma congolense	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania braziliensis	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Toxoplasma gondii	ImpB/MucB/SamB family protein	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus multilocularis	dna polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma brucei gambiense	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Brugia malayi	Tyrosine-protein kinase PR2	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/Met protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK/RYK protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Onchocerca volvulus		0.013	0.5384	0.2964
Echinococcus multilocularis	transfer RNA-Thr	0.0091	0.344	0.344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK/ACK protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.006	0.1862	0.1862
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.013	0.5384	0.2964
Entamoeba histolytica	ankyrin repeat protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0091	0.344	0.344
Schistosoma mansoni	nck2/grb4	0.013	0.5384	0.5384
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	tensin	0.013	0.5384	0.5384
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0091	0.344	0.344
Echinococcus multilocularis	N chimaerin	0.013	0.5384	0.5384
Trichomonas vaginalis	protein kinase atn1, putative	0.0091	0.344	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Brugia malayi	SRC-1	0.0221	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.013	0.5384	0.5384
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1862	0.1862
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Trypanosoma brucei	Pseudokinase, putative	0.0091	0.344	1
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0091	0.344	1
Echinococcus multilocularis	protein tyrosine kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Echinococcus granulosus	activin receptor type	0.0091	0.344	0.344
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Schistosoma mansoni	growth factor receptor-bound protein	0.013	0.5384	0.5384
Leishmania major	hypothetical protein, conserved	0.0091	0.344	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0091	0.344	1
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	SH2 domain containing adapter protein F	0.013	0.5384	0.5384
Echinococcus granulosus	tyrosine protein kinase pr2	0.0091	0.344	0.344
Schistosoma mansoni	suppressor of cytokine signaling	0.013	0.5384	0.5384
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Brugia malayi	RhoGAP domain containing protein	0.013	0.5384	0.5384
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0221	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	C-terminal src kinase protein 1	0.0091	0.344	0.344
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0091	0.344	0.344
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1862	0.1862
Echinococcus granulosus	tyrosine protein kinase Src42A	0.013	0.5384	0.5384
Brugia malayi	cytokine inducible SH2-containing protein 5	0.013	0.5384	0.5384
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Brugia malayi	ImpB/MucB/SamB family protein	0.0054	0.1552	0.1552
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0221	1	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Brugia malayi	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	tensin	0.013	0.5384	0.5384
Schistosoma mansoni	suppressor of cytokine signaling	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0741	0.2155
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Brugia malayi	Tensin	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	protein-tyrosine kinase	0.0221	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0091	0.344	1
Schistosoma mansoni	tyrosine protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	STE family protein kinase	0.0091	0.344	1
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5384	0.5384
Entamoeba histolytica	serine/threonine kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	tyrosin kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.013	0.5384	0.5384
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0091	0.344	0.344
Loa Loa (eye worm)	SRC-1	0.0221	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0091	0.344	0.344
Giardia lamblia	Kinase, NEK	0.0091	0.344	1
Schistosoma mansoni	tensin-related	0.013	0.5384	0.5384
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0091	0.344	0.344
Plasmodium falciparum	protein kinase, putative	0.0091	0.344	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.013	0.5384	0.5384
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase shark	0.0221	1	1
Brugia malayi	Protein kinase domain containing protein	0.0221	1	1
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5384	0.5384
Echinococcus multilocularis	signal transduction protein lnk realted	0.013	0.5384	0.5384
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0091	0.344	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.013	0.5384	0.5384
Schistosoma mansoni	tyrosine kinase	0.0221	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0091	0.344	0.344
Echinococcus granulosus	protein tyrosine kinase	0.0091	0.344	0.344
Echinococcus multilocularis		0.013	0.5384	0.5384
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Brugia malayi	Receptor family ligand binding region containing protein	0.0091	0.344	0.344
Schistosoma mansoni	vav2	0.013	0.5384	0.5384
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Echinococcus granulosus	ephrin type A receptor 4 A	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0091	0.344	0.344
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.013	0.5384	0.5384
Entamoeba histolytica	serine/threonine kinase, putative	0.0091	0.344	0.344
Onchocerca volvulus		0.0221	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0091	0.344	0.344
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.344	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0221	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0221	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	tyrosine kinase	0.0221	1	1
Toxoplasma gondii	protein kinase	0.0091	0.344	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0221	1	1
Brugia malayi	SH2 domain containing protein	0.0221	1	1
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	protein tyrosine kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0221	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Entamoeba histolytica	SH2 domain containing protein	0.013	0.5384	0.5384
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Leishmania major	protein kinase, putative	0.0091	0.344	1
Schistosoma mansoni	shc transforming protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Trypanosoma cruzi	protein kinase, putative	0.0091	0.344	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Echinococcus granulosus	natriuretic peptide receptor 1	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase csk	0.0091	0.344	0.344
Entamoeba histolytica	serine/threonine kinase, putative	0.0091	0.344	0.344
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0091	0.344	0.344
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0091	0.344	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0091	0.344	1
Echinococcus multilocularis	tensin	0.013	0.5384	0.5384
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Entamoeba histolytica	serine/threonine kinase, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0091	0.344	0.344
Echinococcus granulosus	SH2 motif	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.013	0.5384	0.5384
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0091	0.344	0.344
Echinococcus multilocularis	integrin linked protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Brugia malayi	Sex muscle abnormal protein 5	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	cysteine surface protein, putative	0.0091	0.344	0.344
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	SH2 domain-containing protein	0.013	0.5384	0.5384
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Schistosoma mansoni	hypothetical protein	0.013	0.5384	0.5384
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0221	1	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Echinococcus granulosus	dna polymerase eta	0.0054	0.1552	0.1552
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0221	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0091	0.344	0.344
Loa Loa (eye worm)	STAT protein	0.013	0.5384	0.5384
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.013	0.5384	0.5384
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0221	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0091	0.344	0.344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.013	0.5384	0.5384
Echinococcus granulosus	receptor type guanylyl cyclase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0221	1	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0054	0.1552	0.4512
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Onchocerca volvulus		0.013	0.5384	0.2964
Echinococcus granulosus	growth factor receptor bound protein 2	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.6098	0.6098
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.013	0.5384	0.5384
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0221	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0221	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0091	0.344	1
Giardia lamblia	Kinase, NEK	0.0091	0.344	1
Brugia malayi	Raf kinase	0.0091	0.344	0.344
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0091	0.344	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0221	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0091	0.344	0.344
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0091	0.344	0.344
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.013	0.5384	0.5384
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0091	0.344	0.344
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.013	0.5384	0.5384
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0091	0.344	0.344
Brugia malayi	ephrin receptor 1 precursor	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Brugia malayi	STAT protein, DNA binding domain containing protein	0.013	0.5384	0.5384
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0091	0.344	0.344
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0091	0.344	0.344
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0091	0.344	0.344
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0091	0.344	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0091	0.344	0.344
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0091	0.344	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0091	0.344	1
Giardia lamblia	Protein 21.1	0.0091	0.344	1
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	SH2 motif	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0221	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	SH2 domain-containing protein	0.013	0.5384	0.5384
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Echinococcus multilocularis	protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine kinase	0.0091	0.344	0.344
Echinococcus granulosus	signal transduction protein lnk realted	0.013	0.5384	0.5384
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0091	0.344	0.344
Echinococcus multilocularis	heat shock protein 70	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Plasmodium falciparum	tyrosine kinase-like protein	0.0091	0.344	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	SH2A	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	tyrosin kinase, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	SH2 domain-containing protein	0.013	0.5384	0.5384
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	c src tyrosine kinase	0.0221	1	1
Schistosoma mansoni	adapter molecule crk	0.013	0.5384	0.5384
Schistosoma mansoni	tensin-related	0.013	0.5384	0.5384
Echinococcus multilocularis	protein kinase	0.0091	0.344	0.344
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.013	0.5384	0.2964
Echinococcus multilocularis	dna polymerase eta	0.0054	0.1552	0.1552
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0091	0.344	0.344
Trypanosoma brucei	protein kinase, putative	0.0091	0.344	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0221	1	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0221	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Brugia malayi	MH2 domain containing protein	0.0144	0.6098	0.6098
Schistosoma mansoni	ephrin receptor	0.0091	0.344	0.344
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0901	0.0901
Echinococcus multilocularis	tyrosine protein kinase csk	0.0091	0.344	0.344
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	NCK adaptor protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0091	0.344	0.344
Schistosoma mansoni	tensin	0.013	0.5384	0.5384
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Onchocerca volvulus		0.013	0.5384	0.2964
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0221	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0221	1	1
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.013	0.5384	0.5384
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.013	0.5384	0.5384
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	integrin-linked kinase	0.0091	0.344	0.344
Entamoeba histolytica	serine/threonine kinase, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0091	0.344	0.344
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0221	1	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0221	1	1
Schistosoma mansoni	tyrosine kinase	0.0221	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.6098	0.6098
Giardia lamblia	Kinase	0.0091	0.344	1
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Echinococcus granulosus	SH2 motif	0.013	0.5384	0.5384
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1862	0.1862
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0221	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0221	1	1
Echinococcus granulosus	SHC transforming protein 3	0.013	0.5384	0.5384
Brugia malayi	Guanylyl cyclase protein 23	0.0091	0.344	0.344
Echinococcus multilocularis	tensin	0.013	0.5384	0.5384
Echinococcus multilocularis	tyrosine protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	SH2 motif	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/INSR protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK protein kinase	0.0221	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.344	1
Schistosoma mansoni	hypothetical protein	0.013	0.5384	0.5384
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase shark	0.0221	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0221	1	1
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	insulin receptor	0.0091	0.344	0.344
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK/CSK protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0221	1	1
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0091	0.344	0.344
Schistosoma mansoni	hypothetical protein	0.0041	0.0901	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1552	0.1552
Onchocerca volvulus		0.0221	1	1
Trichomonas vaginalis	TK family protein kinase	0.0091	0.344	1
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0221	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Echinococcus multilocularis	c src tyrosine kinase	0.0221	1	1
Schistosoma mansoni	GTPase activating protein	0.013	0.5384	0.5384
Plasmodium falciparum	tyrosine kinase-like protein	0.0091	0.344	0.5
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Schistosoma mansoni	signal transduction protein lnk-related	0.013	0.5384	0.5384
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.013	0.5384	0.5384
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0091	0.344	0.344
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0091	0.344	0.344
Leishmania major	DNA polymerase eta, putative	0.0038	0.0741	0.2155
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0901	0.0901
Echinococcus multilocularis	activin receptor type	0.0091	0.344	0.344
Plasmodium falciparum	protein kinase, putative	0.0091	0.344	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus granulosus	activated cdc42 kinase 1	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0221	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Entamoeba histolytica	serine/threonine kinase, putative	0.0091	0.344	0.344
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	growth factor receptor bound protein 2	0.013	0.5384	0.5384
Schistosoma mansoni	growth factor receptor-bound protein	0.013	0.5384	0.5384
Echinococcus granulosus	NCK adaptor protein	0.013	0.5384	0.5384
Onchocerca volvulus		0.013	0.5384	0.2964
Onchocerca volvulus		0.0221	1	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0091	0.344	0.344
Entamoeba histolytica	tyrosin kinase, putative	0.0091	0.344	0.344
Schistosoma mansoni	ephrin receptor	0.0091	0.344	0.344
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0221	1	1
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0221	1	1
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Onchocerca volvulus		0.013	0.5384	0.2964
Onchocerca volvulus		0.0221	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.013	0.5384	0.5384
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Brugia malayi	SH2 domain containing protein	0.0221	1	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	DNA polymerase eta	0.0054	0.1552	0.1552
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	activated cdc42 kinase 1	0.0091	0.344	0.344
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0221	1	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0091	0.344	0.344
Echinococcus multilocularis	SH2 motif	0.013	0.5384	0.5384
Toxoplasma gondii	STE kinase	0.0091	0.344	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Brugia malayi	Protein kinase domain containing protein	0.0221	1	1
Brugia malayi	hypothetical protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0091	0.344	1
Onchocerca volvulus		0.0221	1	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.013	0.5384	0.5384
Echinococcus granulosus	epidermal growth factor receptor	0.0091	0.344	0.344
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trypanosoma cruzi	protein kinase, putative	0.0091	0.344	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0091	0.344	0.344
Leishmania major	protein kinase, putative	0.0091	0.344	1
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0221	1	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0054	0.1552	0.4512
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.013	0.5384	0.5384
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	receptor protein kinase, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0221	1	1
Echinococcus granulosus	tyrosine kinase	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0091	0.344	1
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Plasmodium vivax	protein kinase, putative	0.0091	0.344	0.5
Schistosoma mansoni	serine/threonine RGC	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0091	0.344	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Onchocerca volvulus		0.0221	1	1
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein kinase csk	0.0091	0.344	0.344
Echinococcus granulosus	suppressor of cytokine signaling 7	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Brugia malayi	hypothetical protein	0.0091	0.344	0.344
Echinococcus granulosus	insulin receptor	0.0091	0.344	0.344
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5384	0.5384
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/FER protein kinase	0.0221	1	1
Echinococcus granulosus	N chimaerin	0.013	0.5384	0.5384
Echinococcus granulosus	tyrosine protein kinase Srms	0.0221	1	1
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	FL cytokine receptor	0.0091	0.344	0.344
Echinococcus multilocularis	tyrosine kinase	0.0221	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	tyrosine kinase	0.0221	1	1
Plasmodium falciparum	protein kinase, putative	0.0091	0.344	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.013	0.5384	0.5384
Echinococcus granulosus	SH2 domain containing protein 7	0.013	0.5384	0.5384
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus multilocularis	SHC transforming protein 3	0.013	0.5384	0.5384
Echinococcus multilocularis	activated cdc42 kinase 1	0.0091	0.344	0.344
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.013	0.5384	0.5384
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0091	0.344	0.344
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0091	0.344	0.344
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.013	0.5384	0.5384
Echinococcus granulosus	tyrosine protein kinase Blk	0.0221	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0091	0.344	1
Loa Loa (eye worm)	TK protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Entamoeba histolytica	hypothetical protein, conserved	0.0091	0.344	0.344
Brugia malayi	SH2 domain containing protein	0.013	0.5384	0.5384
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5384	0.5384
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Echinococcus granulosus	hypothetical protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Schistosoma mansoni	tensin	0.013	0.5384	0.5384
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.013	0.5384	0.5384
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.013	0.5384	0.5384
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0091	0.344	0.344
Onchocerca volvulus		0.013	0.5384	0.2964
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus granulosus	protein kinase	0.0091	0.344	0.344
Entamoeba histolytica	tyrosine kinase, putative	0.0091	0.344	0.344
Loa Loa (eye worm)	TK/ABL protein kinase	0.0221	1	1
Echinococcus granulosus	tyrosine protein kinase	0.0091	0.344	0.344
Echinococcus granulosus	expressed conserved protein	0.013	0.5384	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.344	0.344
Echinococcus granulosus	integrin linked protein kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Leishmania major	DNA polymerase eta, putative	0.0054	0.1552	0.4512
Entamoeba histolytica	protein kinase, putative	0.0091	0.344	0.344
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Brugia malayi	hypothetical protein	0.0221	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0091	0.344	0.344
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0091	0.344	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0221	1	1
Schistosoma mansoni	tyrosine kinase	0.0221	1	1
Entamoeba histolytica	protein kinase, putative	0.013	0.5384	0.5384
Echinococcus granulosus	tyrosine protein kinase csk	0.0091	0.344	0.344
Entamoeba histolytica	hypothetical protein	0.0091	0.344	0.344
Trichomonas vaginalis	TKL family protein kinase	0.0091	0.344	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0091	0.344	0.344
Brugia malayi	tRNA modification GTPase TrmE family protein	0.013	0.5384	0.5384
Schistosoma mansoni	protein kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0091	0.344	0.344
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0091	0.344	0.344
Echinococcus multilocularis	epidermal growth factor receptor	0.0091	0.344	0.344
Schistosoma mansoni	tyrosine kinase	0.0091	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.013	0.5384	0.5384

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7667 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1905179

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1539039