Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.1937 | 0.0008 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.042 | 0.042 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0012 | 0.0438 | 0.0438 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.2067 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.042 | 0.042 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.042 | 0.042 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0022 | 0.193 | 0.193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9292 | 0.9292 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.042 | 0.042 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2067 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.042 | 0.042 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.9292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.042 | 0.0452 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.003 | 0.3209 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.042 | 0.0452 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.2067 | 0.0169 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0012 | 0.0438 | 0.0471 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.042 | 0.042 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Echinococcus granulosus | serine protein kinase ATM | 0.003 | 0.3209 | 0.3209 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.2067 | 0.2225 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.9292 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.042 | 0.0452 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.042 | 0.0452 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9292 | 0.9292 |
Brugia malayi | RNA binding protein | 0.0069 | 0.9292 | 1 |
Echinococcus multilocularis | serine protein kinase ATM | 0.003 | 0.3209 | 0.3209 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.042 | 0.042 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.9292 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.255 | 0.2745 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2067 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2067 | 0.6441 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.042 | 0.042 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0022 | 0.193 | 0.193 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.042 | 0.042 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.042 | 0.042 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.042 | 0.042 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.003 | 0.3209 | 0.3454 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.003 | 0.3209 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.042 | 0.042 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0014 | 0.0659 | 0.2052 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.9292 | 0.9292 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0022 | 0.193 | 0.5386 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.042 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.2067 | 0.5879 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9292 | 0.9292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.042 | 0.0452 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.042 | 0.0452 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0022 | 0.193 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.042 | 0.0452 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.042 | 0.042 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0022 | 0.193 | 0.5386 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0012 | 0.0438 | 0.0438 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0022 | 0.193 | 0.5386 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.9292 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0022 | 0.193 | 0.2078 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0022 | 0.193 | 0.193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0659 | 0.2052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9292 | 0.9292 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.042 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.042 | 0.0452 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.042 | 0.042 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2067 | 0.5523 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.042 | 0.042 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2067 | 0.2067 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.042 | 0.0452 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.3209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0438 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.042 | 0.042 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.003 | 0.3209 | 0.3209 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.042 | 0.042 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.2067 | 0.2067 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.2067 | 0.2225 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.3209 | 1 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.1937 | 0.541 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.042 | 0.0452 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.9292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.042 | 0.042 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0022 | 0.193 | 0.5386 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.042 | 0.042 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.042 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.042 | 0.042 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0012 | 0.0438 | 0.0438 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Toxoplasma gondii | FATC domain-containing protein | 0.003 | 0.3209 | 0.273 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0022 | 0.193 | 0.5386 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2067 | 0.5879 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0022 | 0.193 | 0.4987 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.2067 | 0.5879 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0022 | 0.193 | 0.193 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.042 | 0.0452 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.042 | 0.0452 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.042 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0022 | 0.193 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.2067 | 0.2067 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.042 | 0.042 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0022 | 0.193 | 0.2078 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.042 | 0.5 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0022 | 0.193 | 0.4987 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.042 | 0.042 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0022 | 0.193 | 0.4987 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.042 | 0.0452 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0022 | 0.193 | 0.2078 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.042 | 0.0452 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0022 | 0.193 | 0.5386 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0022 | 0.193 | 0.193 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0022 | 0.193 | 0.5386 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.042 | 0.0452 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.9292 | 0.9292 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9292 | 0.9292 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.042 | 0.042 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0022 | 0.193 | 0.2078 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.042 | 0.0452 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.042 | 0.042 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.042 | 0.042 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.2067 | 0.1508 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2067 | 0.2067 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.042 | 0.042 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.042 | 0.0452 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0022 | 0.193 | 0.193 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.042 | 0.042 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.255 | 0.7623 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0659 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0022 | 0.193 | 0.1362 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2067 | 0.6441 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.042 | 0.0452 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0438 | 0.1365 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.042 | 0.0452 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.2067 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.042 | 0.0452 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.042 | 0.042 |
Onchocerca volvulus | 0.0012 | 0.042 | 0.5 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.193 | 0.6016 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.042 | 0.042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.