Detailed information for compound 1539506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.447 | Formula: C23H23N3O3
  • H donors: 0 H acceptors: 2 LogP: 5.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc2n(c1N(C(=O)c1ccco1)C)cccc2OCc1ccccc1C
  • InChi: 1S/C23H23N3O3/c1-4-18-22(25(3)23(27)20-12-8-14-28-20)26-13-7-11-19(21(26)24-18)29-15-17-10-6-5-9-16(17)2/h5-14H,4,15H2,1-3H3
  • InChiKey: CCXMRHALADLJIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0175 0.0163
Brugia malayi glutaminase DH11.1 0.0311 0.6513 0.7423
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0665
Schistosoma mansoni hypothetical protein 0.0034 0.0565 0.0643
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0634 0.1211
Schistosoma mansoni cpg binding protein 0.003 0.0485 0.0549
Schistosoma mansoni hypothetical protein 0.0191 0.3941 0.4598
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0215 0.0227
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0037 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0215 0.0205
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0239 0.0402
Loa Loa (eye worm) hypothetical protein 0.0028 0.0449 0.0494
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0215 0.0205
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0634 0.0637
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0119 0.0121
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0215 0.0227
Schistosoma mansoni cpg binding protein 0.003 0.0485 0.0549
Loa Loa (eye worm) glutaminase 2 0.0311 0.6513 0.7423
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0119 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0215 0.0227
Brugia malayi Pip kinase protein 1 0.0013 0.0119 0.0118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0215 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0634 0.0637
Trichomonas vaginalis set domain proteins, putative 0.0473 1 1
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0291 0.0314
Mycobacterium tuberculosis Conserved protein 0.0024 0.0361 0.0649
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0291 0.0283
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0215 0.0205
Trypanosoma brucei hypothetical protein, conserved 0.0211 0.4374 1
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0119 0.0106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0239 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0215 0.0227
Echinococcus multilocularis geminin 0.0191 0.3941 0.4043
Mycobacterium ulcerans hypothetical protein 0.0024 0.0361 0.0193
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0634 0.1211
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0361 0.0193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0175 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0634 0.0521
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0215 0.0205
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0215 0.0227
Echinococcus granulosus leucine aminopeptidase protein 0.0106 0.211 0.2157
Toxoplasma gondii leucyl aminopeptidase LAP 0.0106 0.211 0.6662
Brugia malayi CXXC zinc finger family protein 0.0029 0.045 0.0496
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.1131 0.1148
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0215 0.0205
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0037 0.0022
Loa Loa (eye worm) hypothetical protein 0.0163 0.3337 0.3794
Brugia malayi Importin beta-1 subunit 0.0033 0.0536 0.0595
Schistosoma mansoni hypothetical protein 0.0191 0.3941 0.4598
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0634 0.0521
Schistosoma mansoni ap endonuclease 0.0019 0.0239 0.0261
Onchocerca volvulus 0.0018 0.0215 0.0199
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0037 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.4374 1
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0186
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0536 0.1227
Schistosoma mansoni importin beta-1 0.0033 0.0536 0.061
Loa Loa (eye worm) hypothetical protein 0.0033 0.0536 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0215 0.0227
Schistosoma mansoni coup transcription factor 0.0018 0.0215 0.0233
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1131 0.3385
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0152 0.3107 0.7022
Plasmodium vivax SET domain protein, putative 0.006 0.1131 0.5081
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0352 0.0346
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0215 0.0233
Trichomonas vaginalis ran, putative 0.0024 0.0352 0.0236
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0361 0.0649
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0404
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0352 0.0805
Echinococcus multilocularis leucine aminopeptidase protein 0.0106 0.211 0.2157
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0361 0.0568
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0119 0.0118
Echinococcus granulosus cpg binding protein 0.003 0.0485 0.0483
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.9724 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0352 0.0548
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0901 0.1011
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0361 0.0568
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0106 0.211 1
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0291 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.4374 1
Echinococcus multilocularis snurportin 1 0.0347 0.7291 0.7493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0215 0.0227
Brugia malayi photoreceptor-specific nuclear receptor 0.0252 0.5244 0.5974
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0352 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0215 0.0227
Brugia malayi Pre-SET motif family protein 0.0416 0.8768 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0106 0.211 0.4679
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0291 0.0322
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0449 0.1655
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0152 0.3107 1
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0291 0.0322
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0119 0.0121
Echinococcus granulosus snurportin 1 0.0347 0.7291 0.7493
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0291 0.0283
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0119 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0215 0.0227
Loa Loa (eye worm) hypothetical protein 0.005 0.0901 0.1011
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0634 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.107 0.1086
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0013 0.0119 0.0273
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0361 0.0193
Entamoeba histolytica hypothetical protein 0.0026 0.0404 0.5537
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0215 0.0205
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0449 0.1026
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0106 0.211 0.5
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0352 0.117
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0112 0.0099
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0152 0.3107 0.7022
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0361 0.0568
Brugia malayi nuclear hormone receptor 0.0018 0.0215 0.0227
Mycobacterium ulcerans hypothetical protein 0.0024 0.0361 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0215 0.0227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0901 0.1011
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0186
Loa Loa (eye worm) pip kinase 2 0.0163 0.3337 0.3794
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0239 0.023
Onchocerca volvulus 0.0163 0.3337 0.3326
Leishmania major hypothetical protein, conserved 0.0028 0.0449 0.0774
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0291 0.0314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0215 0.0205
Leishmania major importin beta-1 subunit, putative 0.0026 0.0404 0.067
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0075 0.0067
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0634 0.0637
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1131 0.1306
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0901 0.1011
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0215 0.0233
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.3107 0.3024
Chlamydia trachomatis cytosol aminopeptidase 0.0106 0.211 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0215 0.0233
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.1131 0.1148
Schistosoma mansoni ap endonuclease 0.0019 0.0239 0.0261
Echinococcus granulosus neuropeptide s receptor 0.0461 0.9724 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0215 0.0227
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0119 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1131 0.1306
Brugia malayi hypothetical protein 0.0018 0.0232 0.0247
Echinococcus multilocularis mitogen activated protein kinase 0.0152 0.3107 0.3184
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0119 0.0106
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0112 0.0099
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0536 0.1397
Leishmania major hypothetical protein, conserved 0.0211 0.4374 1
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0215 0.0233
Brugia malayi follicle stimulating hormone receptor 0.0232 0.4827 0.5497
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0215 0.0205
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0024
Brugia malayi hypothetical protein 0.0009 0.0037 0.0024
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0361 0.0244
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0215 0.0205
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0022
Trypanosoma brucei protein kinase, putative 0.0152 0.3107 0.7104
Loa Loa (eye worm) hypothetical protein 0.0034 0.0565 0.0627
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0239 0.0282
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0239 0.0282
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.3107 0.3024
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0361 0.0355
Brugia malayi Pre-SET motif family protein 0.006 0.1131 0.1273
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0037 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Schistosoma mansoni ran 0.0024 0.0352 0.0394
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0106 0.211 0.4824
Echinococcus granulosus dnaJ subfamily B 0.0406 0.8552 0.8793
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0152 0.3107 0.7022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0239 0.0547
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0273 0.5708 0.5864
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.8768 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0215 0.0205
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0152 0.3107 0.7104
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.3107 0.3024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0404 0.067
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0361 0.0193
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0215 0.0233
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0037 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0239 0.0122
Trichomonas vaginalis glutaminase, putative 0.0311 0.6513 0.6471
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0634 0.0724
Schistosoma mansoni ran 0.0024 0.0352 0.0394
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.045 0.0496
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0449 0.1655
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0215 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1131 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0215 0.0227
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0352 0.0384
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0239 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0215 0.0227
Loa Loa (eye worm) pip kinase 1 0.0013 0.0119 0.0118
Leishmania major GTP-binding protein, putative 0.0024 0.0352 0.0548
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0163 0.3337 0.3421
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0361 0.0355
Schistosoma mansoni hypothetical protein 0.0013 0.0112 0.0112
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0215 0.0227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0075 0.006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0634 0.0637
Giardia lamblia Kinase, CMGC MAPK 0.0152 0.3107 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0565 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0215 0.0227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0037 0.0025
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0163 0.3337 0.389
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0186
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0634 0.0637
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0215 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0215 0.0227
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0037 0.0022
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0106 0.211 1
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0013 0.0119 0.0273
Loa Loa (eye worm) hypothetical protein 0.006 0.1131 0.1273
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0175 0.0181
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0037 0.0022
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0404
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0634 0.0724
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0449 0.1103
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0119 0.0273
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0215 0.0199
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0239 0.2333
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0152 0.3107 0.7022
Schistosoma mansoni cpg binding protein 0.0029 0.045 0.0509
Echinococcus multilocularis cpg binding protein 0.003 0.0485 0.0483
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0215 0.0205
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0175 0.0181
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0024
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0239 0.0255
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.9724 1
Schistosoma mansoni glutaminase 0.0311 0.6513 0.7611
Schistosoma mansoni hypothetical protein 0.0347 0.7291 0.8522
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0163 0.3337 0.389
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0404
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0352 0.078
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0291 0.0283
Plasmodium vivax importin-beta 2, putative 0.0033 0.0536 0.2096
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0449 0.1655
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0152 0.3107 0.7022
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0215 0.0227
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0215 0.0233
Mycobacterium ulcerans glutaminase 0.0311 0.6513 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0215 0.0227
Entamoeba histolytica Ran family GTPase 0.0024 0.0352 0.4523
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0163 0.3337 0.3421
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0355 0.0388
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0181
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0215 0.0205
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0106 0.211 0.4679
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0634 0.1724
Echinococcus granulosus mitogen activated protein kinase 0.0152 0.3107 0.3184
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0634 0.0637
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0215 0.0199
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0119 0.0106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.4827 0.5497
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0291 0.0314
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0215 0.0205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1131 0.1148
Toxoplasma gondii exonuclease III APE 0.0019 0.0239 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.3107 0.3024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0404 0.0289
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0175 0.0163
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0352 0.0384
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0215 0.0227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0215 0.0233
Brugia malayi steroid hormone receptor 0.0018 0.0215 0.0227
Brugia malayi hypothetical protein 0.0009 0.0037 0.0024
Echinococcus granulosus geminin 0.0191 0.3941 0.4043
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0291 0.0665
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0404
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0449 0.0774
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0119 0.0118
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0634 0.1211
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0239 0.0255
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0536 0.1227
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0239 0.0122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0634 0.0706
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0215 0.0233
Onchocerca volvulus 0.006 0.1131 0.1116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0634 0.0521
Brugia malayi ecdysteroid receptor 0.0018 0.0215 0.0227
Echinococcus granulosus importin subunit beta 1 0.0033 0.0536 0.0536
Brugia malayi RNA, U transporter 1 0.0092 0.1823 0.2065
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0215 0.0233
Echinococcus granulosus mitogen activated protein kinase 3 0.0152 0.3107 0.3184
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.3107 0.3621
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0352 0.0548
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0215 0.0205
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0215 0.0199
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0634 0.145
Mycobacterium ulcerans leucyl aminopeptidase 0.0106 0.211 0.2981
Brugia malayi MAP kinase sur-1 0.0152 0.3107 0.3532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0215 0.0227
Plasmodium falciparum M17 leucyl aminopeptidase 0.0106 0.211 1
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.8552 0.8793
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0152 0.3107 0.3532
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0215 0.0205
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0215 0.0233
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0291 0.0283
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0119 0.0273
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1045 0.3097
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0037 0.0022
Schistosoma mansoni hypothetical protein 0.0406 0.8552 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0404 0.0289
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0352 0.078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0075 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0449 0.0774
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0291 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0215 0.0227
Echinococcus multilocularis GPCR, family 2 0.0016 0.0175 0.0163
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0352 0.117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0215 0.0227
Brugia malayi nuclear receptor RXR 0.0009 0.0037 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Loa Loa (eye worm) hypothetical protein 0.0252 0.5244 0.5974
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0239 0.0604
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0175 0.0181
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0215 0.0205
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0404 0.0289
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0215 0.0233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0227
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0072 0.0064
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.7291 0.8312
Brugia malayi cytosol aminopeptidase 0.0021 0.0291 0.0314
Onchocerca volvulus 0.0029 0.045 0.0435
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0273 0.5708 0.5864
Plasmodium falciparum importin beta, putative 0.0033 0.0536 0.2096
Brugia malayi nuclear receptor NHR-88 0.0018 0.0215 0.0227
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0634 0.0706
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0175 0.0163
Echinococcus granulosus GPCR family 2 0.0016 0.0175 0.0163
Brugia malayi Pip kinase protein 2 0.0163 0.3337 0.3794
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0106 0.211 0.4679
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0119 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1131 0.1306
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0239 0.0604
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0239 0.023
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0152 0.3107 0.7022
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.9724 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0152 0.3107 0.3184
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0106 0.211 1
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0291 0.0283
Brugia malayi hypothetical protein 0.0028 0.0449 0.0494
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0291 0.0404
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0186
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0037 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1183 0.1367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0215 0.0205
Loa Loa (eye worm) glutaminase 0.0311 0.6513 0.7423

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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