Detailed information for compound 1539563

Basic information

Technical information
  • TDR Targets ID: 1539563
  • Name: ethyl 1-phenylsulfonylazetidine-3-carboxylate
  • MW: 269.317 | Formula: C12H15NO4S
  • H donors: 0 H acceptors: 3 LogP: 1.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CN(C1)S(=O)(=O)c1ccccc1
  • InChi: 1S/C12H15NO4S/c1-2-17-12(14)10-8-13(9-10)18(15,16)11-6-4-3-5-7-11/h3-7,10H,2,8-9H2,1H3
  • InChiKey: OKTRFNWQZBAQPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-phenylsulfonyl-3-azetidinecarboxylic acid ethyl ester
  • 1-phenylsulfonylazetidine-3-carboxylic acid ethyl ester
  • ZINC04105398
  • MLS000549390
  • SMR000168973
  • ethyl 1-(phenylsulfonyl)-3-azetanecarboxylate
  • MS-1013

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.004 0.0275 0.0378
Brugia malayi MH1 domain containing protein 0.0027 0.0078 0.0078
Brugia malayi MH2 domain containing protein 0.0048 0.0392 0.0392
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0433 0.6648
Loa Loa (eye worm) hypothetical protein 0.0144 0.1798 0.1798
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.1307 0.1307
Brugia malayi Cell death protein 3 precursor 0.003 0.0135 0.0135
Echinococcus granulosus tar DNA binding protein 0.0518 0.7265 1
Echinococcus granulosus snurportin 1 0.0307 0.4188 0.5766
Echinococcus multilocularis Smad4 0.0048 0.0392 0.054
Echinococcus granulosus inhibitor of apoptosis protein 0.004 0.0275 0.0378
Schistosoma mansoni importin beta-1 0.0029 0.0111 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0651 0.0896
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0216 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0461 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0498 0.0686
Echinococcus multilocularis tar DNA binding protein 0.0518 0.7265 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0367 0.0506
Echinococcus granulosus calpain A 0.0061 0.0587 0.0808
Loa Loa (eye worm) hypothetical protein 0.0037 0.0235 0.0235
Echinococcus multilocularis calpain family protein 1, d 0.012 0.144 0.1983
Echinococcus multilocularis inhibitor of apoptosis protein 0.004 0.0275 0.0378
Echinococcus multilocularis hypothetical protein 0.0061 0.0587 0.0808
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0162 0.2068 0.2846
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0135 0.056
Brugia malayi MH1 domain containing protein 0.0048 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0239 0.3184 0.4383
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0111
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.004 0.0275 0.0378
Schistosoma mansoni hypothetical protein 0.0111 0.1307 0.18
Schistosoma mansoni tar DNA-binding protein 0.0518 0.7265 1
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0651 1
Brugia malayi mbt repeat family protein 0.0046 0.0367 0.0367
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0216 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0651 0.0896
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0433 0.6648
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0651 0.0651
Echinococcus multilocularis mothers against decapentaplegic 2 0.0021 0.0004 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0216 0.3319
Schistosoma mansoni tar DNA-binding protein 0.0518 0.7265 1
Onchocerca volvulus 0.004 0.0275 0.1156
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0651 0.0651
Brugia malayi hypothetical protein 0.0033 0.0169 0.0169
Brugia malayi Latrophilin receptor protein 2 0.0111 0.1307 0.1307
Echinococcus granulosus geminin 0.0169 0.2166 0.2982
Onchocerca volvulus 0.003 0.0135 0.056
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0587 0.0808
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.02 0.0276
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.2359 0.3248
Echinococcus granulosus calpain 5 0.0061 0.0587 0.0808
Loa Loa (eye worm) calpain family protein 1 0.012 0.144 0.144
Brugia malayi MH1 domain containing protein 0.0027 0.0078 0.0078
Leishmania major hypothetical protein, conserved 0.0036 0.0216 0.3319
Loa Loa (eye worm) Smad1 0.0048 0.0392 0.0392
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0111 0.1709
Echinococcus granulosus mothers against decapentaplegic 5 0.0048 0.0392 0.054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.1307 0.18
Schistosoma mansoni smad 0.0048 0.0392 0.054
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0651 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0461 0.0461
Schistosoma mansoni calpain C (C02 family) 0.0061 0.0587 0.0808
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0651 0.0896
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0433 0.6648
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0216 0.0216
Entamoeba histolytica calpain large subunit domain III containing protein 0.0043 0.0317 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0461 0.0635
Loa Loa (eye worm) hypothetical protein 0.0036 0.0216 0.0216
Echinococcus multilocularis geminin 0.0169 0.2166 0.2982
Brugia malayi beta-lactamase 0.0036 0.0216 0.0216
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.017 0.2175 0.2994
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Leishmania major importin beta-1 subunit, putative 0.0023 0.0032 0.0485
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0367 0.0506
Loa Loa (eye worm) TAR-binding protein 0.0518 0.7265 0.7265
Brugia malayi calpain 5 0.0043 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.012 0.144 0.144
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0367 0.0506
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0461 0.0635
Mycobacterium ulcerans hypothetical protein 0.0036 0.0216 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0651 1
Brugia malayi RNA binding protein 0.0518 0.7265 0.7265
Brugia malayi Smad1 0.0048 0.0392 0.0392
Echinococcus multilocularis snurportin 1 0.0307 0.4188 0.5766
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0216 0.5
Schistosoma mansoni tar DNA-binding protein 0.0518 0.7265 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.3052 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0651 0.0896
Loa Loa (eye worm) calpain 5 0.0043 0.0317 0.0317
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0048 0.0392 0.054
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0135 0.0186
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0433 0.6648
Echinococcus multilocularis mothers against decapentaplegic 5 0.0048 0.0392 0.054
Schistosoma mansoni calpain (C02 family) 0.0061 0.0587 0.0808
Echinococcus multilocularis calpain 5 0.0061 0.0587 0.0808
Echinococcus granulosus calpain 0.0061 0.0587 0.0808
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0651 0.0896
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0135 0.0186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.1307 0.18
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0651 0.0896
Trypanosoma brucei antigen, putative 0.0061 0.0587 0.9015
Brugia malayi Importin beta-1 subunit 0.0029 0.0111 0.0111
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0538 0.074
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2349 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0021 0.0004 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0216 1
Plasmodium vivax calpain, putative 0.0061 0.0587 0.9015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0216 0.0216
Brugia malayi N-terminal motif family protein 0.0182 0.2349 0.2349
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.017 0.2175 0.2994
Echinococcus granulosus importin subunit beta 1 0.0029 0.0111 0.0153
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0651 1
Echinococcus multilocularis calpain 0.0061 0.0587 0.0808
Schistosoma mansoni tar DNA-binding protein 0.0518 0.7265 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0538 0.074
Schistosoma mansoni Smad4 0.0048 0.0392 0.054
Brugia malayi MH1 domain containing protein 0.0048 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0101 0.1171 0.1171
Echinococcus granulosus Smad4 0.0048 0.0392 0.054
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0367 0.0506
Schistosoma mansoni smad1 5 8 and 0.0048 0.0392 0.054
Schistosoma mansoni hypothetical protein 0.0023 0.0023 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0048 0.0392 0.0392
Schistosoma mansoni smad1 5 8 and 0.0048 0.0392 0.054
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0587 0.9015
Schistosoma mansoni smad1 5 8 and 0.0048 0.0392 0.054
Echinococcus multilocularis calpain A 0.017 0.2175 0.2994
Schistosoma mansoni hypothetical protein 0.003 0.0135 0.0186
Brugia malayi beta-lactamase family protein 0.0036 0.0216 0.0216
Brugia malayi mothers against decapentaplegic homolog 3 0.0021 0.0004 0.0004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.02 0.0276
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0367 0.0367
Brugia malayi latrophilin 2 splice variant baaae 0.0239 0.3184 0.3184
Echinococcus granulosus TGF beta signal transducer SmadC 0.0048 0.0392 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0498 0.0686
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0651 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.1307 0.18
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0032 0.1461
Loa Loa (eye worm) hypothetical protein 0.0036 0.0216 0.0216
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0587 0.9015
Echinococcus granulosus mothers against decapentaplegic 6 0.0021 0.0004 0.0005
Echinococcus granulosus smad 0.0048 0.0392 0.054
Schistosoma mansoni hypothetical protein 0.004 0.0275 0.0378
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0216 1
Loa Loa (eye worm) nuclear factor I 0.0027 0.0078 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0498 0.0498
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.2359 0.3248
Echinococcus granulosus calpain 7 C02 family 0.0061 0.0587 0.0808
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0587 0.9015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.4188 0.4188
Trypanosoma brucei kinesin, putative 0.0043 0.0317 0.4872
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0032 0.0485
Loa Loa (eye worm) transcription factor SMAD2 0.0704 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0296 0.0296
Loa Loa (eye worm) beta-lactamase 0.0036 0.0216 0.0216
Brugia malayi calpain 7 0.0061 0.0587 0.0587
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0216 1
Onchocerca volvulus 0.0036 0.0216 0.0905
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0349 0.4802 0.4802
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0498 0.0686
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0023 0.0032
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0367 0.0506
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0 0.5
Echinococcus multilocularis calpain 7 (C02 family) 0.0061 0.0587 0.0808
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0216 0.0297
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0023 0.0032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0498 0.0498
Loa Loa (eye worm) MH2 domain-containing protein 0.0704 1 1
Schistosoma mansoni hypothetical protein 0.0111 0.1307 0.18
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0216 0.0297
Loa Loa (eye worm) hypothetical protein 0.004 0.0268 0.0268
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0651 0.0896
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0349 0.4802 0.4802
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0216 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0651 1
Brugia malayi MH2 domain containing protein 0.0021 0.0004 0.0004
Schistosoma mansoni inhibitor of apoptosis protein 0.004 0.0275 0.0378
Loa Loa (eye worm) hypothetical protein 0.0053 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0046 0.0367 0.0367
Echinococcus multilocularis GPCR, family 2 0.0111 0.1307 0.18
Brugia malayi calpain family protein 1 0.0162 0.2068 0.2068
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0216 0.5
Echinococcus granulosus caspase 2 0.003 0.0135 0.0186
Brugia malayi hypothetical protein 0.0051 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0036 0.0216 0.0216
Schistosoma mansoni Smad4 0.0021 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0275 0.0275
Schistosoma mansoni hypothetical protein 0.0281 0.3808 0.5242
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0216 0.0297
Brugia malayi Bromodomain containing protein 0.0073 0.0755 0.0755
Echinococcus granulosus calpain A 0.017 0.2175 0.2994
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0004 0.0004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.001 0.0014
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0587 0.9015
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0032 0.1461
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Schistosoma mansoni hypothetical protein 0.0307 0.4188 0.5766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0498 0.0686
Brugia malayi RNA recognition motif domain containing protein 0.0518 0.7265 0.7265
Entamoeba histolytica protein kinase, putative 0.0043 0.0317 1
Plasmodium falciparum importin beta, putative 0.0029 0.0111 0.1709
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0162 0.2068 0.2068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0518 0.7265 0.7265
Brugia malayi calpain family protein 1 0.0162 0.2068 0.2068
Onchocerca volvulus 0.0101 0.1171 0.4976
Mycobacterium ulcerans beta-lactamase 0.0036 0.0216 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0651 1
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0587 0.0808
Brugia malayi beta-lactamase family protein 0.0036 0.0216 0.0216
Onchocerca volvulus 0.0036 0.0216 0.0905
Entamoeba histolytica hypothetical protein 0.0023 0.0032 0.0995
Onchocerca volvulus 0.0046 0.0367 0.155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0111 0.0153
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0367 0.155
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0461 0.0635
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0433 0.6648
Leishmania major hypothetical protein, conserved 0.0051 0.0433 0.6648
Schistosoma mansoni tar DNA-binding protein 0.0518 0.7265 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Loa Loa (eye worm) hypothetical protein 0.004 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0036 0.0216 0.0216
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0587 0.9015
Brugia malayi isocitrate dehydrogenase 0.0066 0.0651 0.0651
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0111 0.1709
Schistosoma mansoni bromodomain containing protein 0.0061 0.0589 0.081
Echinococcus granulosus baculoviral IAP repeat containing protein 0.004 0.0275 0.0378
Schistosoma mansoni Mername-AA248 (C02 family) 0.0061 0.0587 0.0808
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0587 0.9015
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0216 0.3319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0498 0.0686
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0048 0.0392 0.054
Schistosoma mansoni hypothetical protein 0.0111 0.1307 0.18
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.1307 0.18
Brugia malayi PHD-finger family protein 0.0024 0.0044 0.0044
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0651 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0587 0.9015
Schistosoma mansoni Smad4 0.0021 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0051 0.0433 0.0433
Echinococcus granulosus GPCR family 2 0.0111 0.1307 0.18
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.004 0.0275 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0216 0.3319
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0651 1
Trypanosoma cruzi kinesin, putative 0.0043 0.0317 0.4872
Loa Loa (eye worm) hypothetical protein 0.0239 0.3184 0.3184
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Trichomonas vaginalis esterase, putative 0.0036 0.0216 1
Brugia malayi mbt repeat family protein 0.0046 0.0367 0.0367
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0367 0.0506
Loa Loa (eye worm) hypothetical protein 0.0182 0.2349 0.2349
Loa Loa (eye worm) hypothetical protein 0.0036 0.0216 0.0216
Echinococcus multilocularis caspase 2 0.003 0.0135 0.0186
Brugia malayi hypothetical protein 0.003 0.0135 0.0135
Brugia malayi MH2 domain containing protein 0.0048 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0111 0.1307 0.1307
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0135 0.0186
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0587 0.9015
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0461 0.0635
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.004 0.0275 0.0275
Loa Loa (eye worm) MH1 domain-containing protein 0.0048 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0169 0.2166 0.2982
Trypanosoma cruzi kinesin, putative 0.0043 0.0317 0.4872
Brugia malayi TAR-binding protein 0.0518 0.7265 0.7265
Loa Loa (eye worm) hypothetical protein 0.0349 0.4802 0.4802
Loa Loa (eye worm) RNA binding protein 0.0518 0.7265 0.7265
Brugia malayi Bromodomain containing protein 0.0037 0.0234 0.0234
Schistosoma mansoni smad 0.0021 0.0004 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.1307 0.1307
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0587 0.9015
Brugia malayi RNA, U transporter 1 0.0082 0.0888 0.0888
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0216 0.3319
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.001 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0433 0.6648
Schistosoma mansoni hypothetical protein 0.0169 0.2166 0.2982
Echinococcus multilocularis smad 0.0048 0.0392 0.054
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0111 0.1709
Brugia malayi Calcitonin receptor-like protein seb-1 0.0349 0.4802 0.4802
Plasmodium vivax importin-beta 2, putative 0.0029 0.0111 0.1709
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.001 0.0014
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0651 0.1534
Echinococcus multilocularis mothers against decapentaplegic 6 0.0021 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0694 0.0694
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0032 0.1461
Toxoplasma gondii ABC1 family protein 0.0036 0.0216 0.3319
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0587 0.9015
Onchocerca volvulus 0.0036 0.0216 0.0905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0498 0.0686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0498 0.0686
Schistosoma mansoni hypothetical protein 0.0111 0.1307 0.18
Onchocerca volvulus Deterin homolog 0.004 0.0275 0.1156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0216 0.0297
Loa Loa (eye worm) MBCTL1 0.0053 0.0461 0.0461
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Leishmania major kinesin, putative 0.0043 0.0317 0.4872
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0135
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0367 0.0506
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.017 0.2175 0.2994
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0433 0.6648
Mycobacterium ulcerans lipase LipD 0.0036 0.0216 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0004 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0587 0.9015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.017 0.2175 0.2994
Mycobacterium leprae Probable lipase LipE 0.0036 0.0216 0.5
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0587 0.9015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0216 0.0216
Loa Loa (eye worm) calpain family protein 1 0.0162 0.2068 0.2068
Loa Loa (eye worm) calpain 0.0061 0.0587 0.0587

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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