Detailed information for compound 1539761

Basic information

Technical information
  • TDR Targets ID: 1539761
  • Name: but-2-enedioic acid; 1-(2-dimethylaminoethyla mino)-2-methoxy-4-methylthioxanthen-9-one
  • MW: 458.527 | Formula: C23H26N2O6S
  • H donors: 3 H acceptors: 5 LogP: 1.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C/C(=O)O.COc1cc(C)c2c(c1NCCN(C)C)c(=O)c1c(s2)cccc1
  • InChi: 1S/C19H22N2O2S.C4H4O4/c1-12-11-14(23-4)17(20-9-10-21(2)3)16-18(22)13-7-5-6-8-15(13)24-19(12)16;5-3(6)1-2-4(7)8/h5-8,11,20H,9-10H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
  • InChiKey: REHIDBKFPHFTPN-WLHGVMLRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • but-2-enedioic acid; 1-(2-dimethylaminoethylamino)-2-methoxy-4-methyl-thioxanthen-9-one
  • but-2-enedioic acid; 1-(2-dimethylaminoethylamino)-2-methoxy-4-methyl-9-thioxanthenone
  • NSC320249

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens Wolf-Hirschhorn syndrome candidate 1 Starlite/ChEMBL No references
Homo sapiens perilipin 1 Starlite/ChEMBL No references
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens RAD54-like (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) type III restriction enzyme Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Cryptosporidium hominis DNA repair protein RAD54-like Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus DNA repair and recombination protein RAD54B Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RAD54 like SWI/SNF2 ATpase Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01529 RAD54L, GdRAD54; RAD54-like [EC:3.6.1.-], putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax DNA repair protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Histone-lysine N-methyltransferase NSD3, putative Get druggable targets OG5_130029 All targets in OG5_130029
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130029 All targets in OG5_130029
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii DNA repair protein RAD54-like-related Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR000299,Band 4.1,domain-containing Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma mansoni SET domain protein Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Babesia bovis DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Brugia malayi recombination factor GdRad54 Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA repair and recombination protein RAD54B, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva DNA repair protein rad54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ATP-dependent RNA helicase DDX1, putative Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Type III restriction enzyme, res subunit family protein Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania braziliensis DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major hypothetical protein, conserved RAD54-like (S. cerevisiae) 747 aa 633 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0269 0.0814
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Brugia malayi TAR-binding protein 0.0071 0.1585 0.4776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0121 0.0342
Echinococcus multilocularis hepatoma derived growth factor protein 0.0011 0.0136 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2312 1
Echinococcus granulosus hepatoma derived growth factor protein 0.0011 0.0136 0.0218
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0136 0.4155
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0319 0.5963
Loa Loa (eye worm) hypothetical protein 0.0037 0.0745 0.2188
Echinococcus multilocularis dna repair and recombination protein rad54 0.001 0.0091 0.0015
Schistosoma mansoni hypothetical protein 0.0017 0.0269 0.114
Schistosoma mansoni hepatoma derived growth factor 0.0011 0.0136 0.0565
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.2312 0.6828
Echinococcus multilocularis GPCR, family 2 0.0017 0.0269 0.0814
Echinococcus granulosus peregrin 0.0011 0.0136 0.0218
Schistosoma mansoni Smad4 0.0009 0.0087 0.0355
Loa Loa (eye worm) TAR-binding protein 0.0071 0.1585 0.4675
Brugia malayi RNA binding protein 0.0071 0.1585 0.4776
Entamoeba histolytica DNA repair protein, putative 0.001 0.0091 0.0091
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0326 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0087 0.0242
Echinococcus multilocularis peregrin 0.0011 0.0136 0.0218
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0474 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0136 0.0386
Echinococcus granulosus SPRY domain containing protein 0.001 0.0091 0.0015
Echinococcus multilocularis 0.001 0.0091 0.0015
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0319 0.1042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0121 0.0342
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0411 0.1759
Echinococcus multilocularis SPRY domain containing protein 0.001 0.0091 0.0015
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0011 0.0136 0.4155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0121 0.0151
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0121 0.0151
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0147 0.0269
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.2312 0.7095
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0121 0.0151
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0006 0.5
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.001 0.0091 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1585 0.6847
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0121 0.0107
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0147 0.147
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0269 0.0577
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0319 0.5
Entamoeba histolytica hypothetical protein 0.0119 0.2744 0.2744
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1585 0.6847
Loa Loa (eye worm) hypothetical protein 0.0146 0.3383 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0253
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.001 0.0091 0.0371
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Echinococcus multilocularis dna repair and recombination protein rad54 0.001 0.0091 0.0015
Schistosoma mansoni SET domain protein 0.0013 0.0168 0.0704
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0319 0.9781
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0121 0.0501
Echinococcus multilocularis PWWP domain containing protein 2A 0.0011 0.0136 0.0218
Echinococcus granulosus bloom syndrome protein 0.0029 0.0559 0.2118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0121 0.0107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0269 0.0778
Schistosoma mansoni DNA helicase recq1 0.0012 0.0147 0.0615
Loa Loa (eye worm) type III restriction enzyme 0.001 0.0091 0.0253
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.004 0.0814 0.3267
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0011 0.0136 0.4155
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0147 0.0269
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0232 0.7233
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0319 1
Brugia malayi hypothetical protein 0.0011 0.0136 0.0154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0121 0.0501
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0319 0.0739
Schistosoma mansoni hepatoma derived growth factor 0.0011 0.0136 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0121 0.0342
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0147 0.0269
Echinococcus granulosus SPRY domain containing protein 0.001 0.0091 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0121 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0121 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0253
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0147 0.4422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0269 0.0778
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0121 0.0151
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0121 0.0342
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0319 0.1042
Schistosoma mansoni hypothetical protein 0.0011 0.0136 0.0565
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0232 0.6195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2312 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0147 0.042
Loa Loa (eye worm) hypothetical protein 0.0054 0.1155 0.3402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0121 0.0342
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0121 0.0151
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0011 0.0136 0.4155
Echinococcus multilocularis 0.001 0.0091 0.0016
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0319 0.136
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0121 0.0501
Schistosoma mansoni phd finger protein 0.0011 0.0136 0.0565
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0121 0.0151
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0232 0.0232
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0269 0.0814
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0147 0.0191
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0319 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0559 1
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.001 0.0091 0.2728
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0147 0.0191
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0319 0.9781
Schistosoma mansoni smad1 5 8 and 0.0009 0.0087 0.0355
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0559 0.2118
Loa Loa (eye worm) RecQ helicase 0.0029 0.0559 0.1637
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.3223 0.9524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2312 1
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.001 0.0091 0.0016
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0168 0.0362
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0087 0.0242
Schistosoma mansoni hypothetical protein 0.0011 0.0136 0.0565
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0559 0.1503
Brugia malayi hypothetical protein 0.0011 0.0136 0.0154
Echinococcus granulosus PWWP domain containing protein 2A 0.0011 0.0136 0.0218
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0121 0.0501
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0121 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2312 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0319 0.962
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0147 0.0269
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0121 0.0107
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0121 0.0501
Onchocerca volvulus 0.0011 0.0136 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0319 0.1042
Toxoplasma gondii hypothetical protein 0.0011 0.0136 0.4064
Brugia malayi MH2 domain containing protein 0.0139 0.3223 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0121 0.0501
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0121 0.0151
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0319 0.0928
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2312 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0121 0.0151
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0559 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0121 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0121 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1155 0.3402
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.3223 0.9524
Schistosoma mansoni SET domain protein 0.004 0.0814 0.3506
Echinococcus granulosus tar DNA binding protein 0.0071 0.1585 0.6731
Echinococcus multilocularis SPRY domain containing protein 0.001 0.0091 0.0015
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0006 0.0006
Loa Loa (eye worm) PWWP domain-containing protein 0.0011 0.0136 0.0386
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0253
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0269 0.0577
Entamoeba histolytica DNA repair protein, putative 0.001 0.0091 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0121 0.0107
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0319 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0269 0.0814
Echinococcus granulosus GPCR family 2 0.0017 0.0269 0.0814
Brugia malayi isocitrate dehydrogenase 0.0019 0.0319 0.0739
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1585 0.6847
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0121 0.0342
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0121 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0121 0.0151
Schistosoma mansoni DNA helicase recq5 0.0012 0.0147 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0121 0.0107
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0147 0.042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0121 0.0151
Brugia malayi steroid hormone receptor 0.0011 0.0121 0.0107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0121 0.0151
Trypanosoma brucei transcription elongation factor s-II, putative 0.0011 0.0136 0.1962
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0121 0.0501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1155 0.3404
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1585 0.6847
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0121 0.0501
Brugia malayi Type III restriction enzyme, res subunit family protein 0.001 0.0091 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0121 0.0107
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.1585 0.4675
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0269 0.0814
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0121 0.0501
Brugia malayi nuclear hormone receptor 0.0011 0.0121 0.0107
Loa Loa (eye worm) Smad1 0.0009 0.0087 0.0242
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0121 0.0501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2312 1
Echinococcus multilocularis tar DNA binding protein 0.0071 0.1585 0.6731
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2312 1
Entamoeba histolytica hypothetical protein 0.0011 0.0136 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0121 0.0107
Onchocerca volvulus 0.0011 0.0136 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0232 0.6195
Plasmodium vivax DNA repair protein RAD54, putative 0.001 0.0091 0.2747
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.2744 0.2744
Schistosoma mansoni hypothetical protein 0.0017 0.0269 0.114
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0319 0.1042
Echinococcus granulosus PWWP domain containing protein 2A 0.0011 0.0136 0.0218
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0319 0.1042
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0253
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0121 0.0151
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0087 0.0355
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0332 1
Brugia malayi PWWP domain containing protein 0.0011 0.0136 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0121 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0121 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0121 0.0107
Echinococcus multilocularis dna repair and recombination protein rad54 0.001 0.0091 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0121 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0121 0.0342
Giardia lamblia DNA repair protein RAD52 0.042 1 1
Loa Loa (eye worm) RNA binding protein 0.0071 0.1585 0.4675
Schistosoma mansoni smad 0.0009 0.0087 0.0355
Schistosoma mansoni hypothetical protein 0.0037 0.0745 0.3204
Brugia malayi nuclear receptor NHR-88 0.0011 0.0121 0.0107
Echinococcus granulosus dna repair and recombination protein rad54 0.001 0.0091 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0121 0.0501
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0745 0.2096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1155 0.3404
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0136 0.4155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0121 0.0107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0121 0.0501
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1585 0.6847
Brugia malayi recombination factor GdRad54 0.001 0.0091 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Schistosoma mansoni smad1 5 8 and 0.0009 0.0087 0.0355
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0121 0.0107
Brugia malayi ecdysteroid receptor 0.0011 0.0121 0.0107
Schistosoma mansoni hypothetical protein 0.0011 0.0136 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0121 0.0342
Echinococcus multilocularis PWWP domain containing protein 2A 0.0011 0.0136 0.0218
Leishmania major hypothetical protein, conserved 0.0011 0.0136 0.1962
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0121 0.0151
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0319 1
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.001 0.0091 0.2728
Schistosoma mansoni hypothetical protein 0.0017 0.0269 0.114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0319 0.1042
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0168 0.0362
Echinococcus granulosus SPRY domain containing protein 0.001 0.0091 0.0015
Schistosoma mansoni hypothetical protein 0.0017 0.0269 0.114
Schistosoma mansoni smad1 5 8 and 0.0009 0.0087 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0121 0.0107
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0147 0.4422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0121 0.0151
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.1585 0.4776
Loa Loa (eye worm) hypothetical protein 0.0011 0.0121 0.0342
Schistosoma mansoni coup transcription factor 0.0011 0.0121 0.0501
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.004 0.0814 0.3267

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.07 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 2.7 uM PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) 5.29 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 6.301 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 36.128 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 71.39 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.1821 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 24.1489 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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