Detailed information for compound 1539770

Basic information

Technical information
  • TDR Targets ID: 1539770
  • Name: 1-[1-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c ]pyrazine-2-carbonyl)cyclohexyl]-3-(2,6-dimet hylphenyl)urea
  • MW: 398.542 | Formula: C23H34N4O2
  • H donors: 2 H acceptors: 2 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1(CCCCC1)C(=O)N1CCN2C(C1)CCC2)Nc1c(C)cccc1C
  • InChi: 1S/C23H34N4O2/c1-17-8-6-9-18(2)20(17)24-22(29)25-23(11-4-3-5-12-23)21(28)27-15-14-26-13-7-10-19(26)16-27/h6,8-9,19H,3-5,7,10-16H2,1-2H3,(H2,24,25,29)
  • InChiKey: PGWKOKLUPUBLHE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[1-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c]pyrazin-2-yl-oxomethyl)cyclohexyl]-3-(2,6-dimethylphenyl)urea
  • 1-[1-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c]pyrazin-2-ylcarbonyl)cyclohexyl]-3-(2,6-dimethylphenyl)urea
  • ASN 08833595

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0038 0.0258 0.2047
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.062 0.5242 0.6623
Echinococcus multilocularis NADH dehydrogenase 0.0063 0.0465 0.0698
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0038 0.0258 0.4712
Schistosoma mansoni alcohol dehydrogenase 0.0038 0.0258 0.0607
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Schistosoma mansoni DNA polymerase eta 0.0019 0.0089 0.0208
Mycobacterium ulcerans dehydrogenase 0.0038 0.0258 0.0218
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0658 0.5572 0.7047
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0658 0.5572 0.6981
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0089 0.0703
Brugia malayi CXXC zinc finger family protein 0.0028 0.0167 0.0167
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0067 0.0534
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0067 0.0073
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0658 0.5572 0.6981
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0095 0.0743 0.0841
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0067 0.0067
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.062 0.5242 0.5242
Mycobacterium leprae conserved hypothetical protein 0.0063 0.0465 0.0271
Trypanosoma brucei unspecified product 0.0019 0.0089 0.0703
Leishmania major oxidoreductase-like protein 0.0038 0.0258 0.1306
Echinococcus granulosus cpg binding protein 0.0029 0.0181 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium ulcerans oxidoreductase FadB5 0.0038 0.0258 0.0218
Echinococcus multilocularis smad 0.0016 0.0067 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Onchocerca volvulus 0.0579 0.4893 0.5145
Brugia malayi Cathepsin L-like precursor 0.0016 0.0067 0.0067
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0095 0.0743 0.0841
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Echinococcus multilocularis cysteine protease 0.0016 0.0067 0.0101
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0191 0.1562 0.1893
Onchocerca volvulus 0.0011 0.0021 0.0018
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0063 0.0465 0.0271
Loa Loa (eye worm) nuclear factor I 0.0009 0.0005 0.0003
Schistosoma mansoni Smad4 0.0016 0.0067 0.0157
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0548 0.1288
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0038 0.0258 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0156 0.1262 0.1262
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0038 0.0258 0.0218
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0195 0.1597 0.1939
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0926 0.787 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0009
Onchocerca volvulus 0.0016 0.0067 0.0067
Onchocerca volvulus Putative alcohol dehydrogenase 0.0038 0.0258 0.0268
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0067 0.0157
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0009
Mycobacterium tuberculosis Conserved protein 0.0187 0.1529 0.1851
Echinococcus granulosus Smad4 0.0016 0.0067 0.0157
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0499 0.4204 0.5288
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0089 0.058
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0038 0.0258 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Toxoplasma gondii type I fatty acid synthase 0.0095 0.0743 0.1328
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0151 0.1227 0.1462
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0156 0.1262 1
Mycobacterium tuberculosis Possible dehydrogenase 0.0038 0.0258 0.0218
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0021 0.0391
Leishmania major DNA polymerase kappa, putative 0.0019 0.0089 0.0145
Loa Loa (eye worm) hypothetical protein 0.1041 0.8855 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0067 0.0101
Onchocerca volvulus 0.0016 0.0067 0.0067
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.062 0.5242 0.6623
Brugia malayi Cathepsin L-like precursor 0.0016 0.0067 0.0067
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0197 0.1563
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0038 0.0258 0.169
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0197 0.0197
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0004 0.0002
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0197 0.0296
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0063 0.0465 0.0485
Mycobacterium ulcerans acyl carrier protein 0.0063 0.0465 0.0484
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0095 0.0743 0.0841
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0289
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0465 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0089 0.0703
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0063 0.0465 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0089 0.0703
Mycobacterium ulcerans polyketide synthase MbtD 0.0191 0.1562 0.1893
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0038 0.0258 0.0218
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0067 0.0073
Schistosoma mansoni acyl carrier protein 0.0063 0.0465 0.1093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Brugia malayi hypothetical protein 0.0009 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0601 0.5079 0.6413
Entamoeba histolytica cysteine protease, putative 0.0016 0.0067 0.123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0021 0.005
Echinococcus granulosus acyl carrier protein mitochondrial 0.0063 0.0465 0.1093
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0038 0.0258 0.0218
Mycobacterium tuberculosis Possible dehydrogenase 0.0038 0.0258 0.0218
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0004 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0197 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0038 0.0258 0.0218
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0548 0.1288
Leishmania major zinc-binding dehydrogenase-like protein 0.0038 0.0258 0.1306
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0098
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0156 0.1262 0.1893
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0067 0.0534
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0156 0.1262 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0004 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Chlamydia trachomatis acyl carrier protein 0.0063 0.0465 0.2016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0197 0.1563
Brugia malayi Smad1 0.0016 0.0067 0.0067
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1192 0.1192
Trypanosoma cruzi oxidoreductase, putative 0.0038 0.0258 0.2047
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1156 0.2716
Mycobacterium ulcerans polyketide synthase 0.0658 0.5572 0.7047
Echinococcus granulosus cathepsin l1 0.0011 0.0021 0.005
Schistosoma mansoni zinc binding dehydrogenase 0.0038 0.0258 0.0607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0038 0.0258 0.0258
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0039 0.0264 0.0053
Leishmania major hypothetical protein, conserved 0.0187 0.1529 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0181 0.0271
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0167 0.0186
Brugia malayi MH2 domain containing protein 0.0016 0.0067 0.0067
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1192 0.2799
Brugia malayi Phosphopantetheine attachment site family protein 0.0063 0.0465 0.0465
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.062 0.5242 0.6623
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0352 0.2949 0.3676
Mycobacterium leprae Polyketide synthase Pks13 0.0926 0.787 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0516 0.4356 0.5384
Mycobacterium ulcerans Type I modular polyketide synthase 0.062 0.5242 0.6623
Brugia malayi isocitrate dehydrogenase 0.0031 0.0197 0.0197
Echinococcus multilocularis Smad4 0.0016 0.0067 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.1529 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0089 0.0703
Brugia malayi Alcohol dehydrogenase class III 0.0038 0.0258 0.0258
Brugia malayi DIX domain containing protein 0.0009 0.0004 0.0004
Schistosoma mansoni methyltransferase-related 0.0187 0.1529 0.3592
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0548 0.4345
Schistosoma mansoni cpg binding protein 0.0029 0.0181 0.0424
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0548 0.329
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1192 0.1788
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0067 0.123
Schistosoma mansoni smad1 5 8 and 0.0016 0.0067 0.0157
Loa Loa (eye worm) hypothetical protein 0.0095 0.0743 0.0837
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0038 0.0258 0.4712
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0038 0.0258 0.169
Onchocerca volvulus 0.0016 0.0067 0.0067
Onchocerca volvulus Fatty acid synthase homolog 0.1117 0.9507 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0156 0.1262 0.2965
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0548 1
Trypanosoma cruzi acyl transferase-like protein 0.0039 0.0264 0.209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0191 0.1562 0.1562
Mycobacterium ulcerans fatty acid synthase Fas 0.0195 0.1597 0.1939
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0089 0.0133
Giardia lamblia Methyltransferase like 2 0.0187 0.1529 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0063 0.0465 0.0484
Onchocerca volvulus 0.1079 0.9177 0.9653
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0002
Plasmodium vivax acyl carrier protein, putative 0.0063 0.0465 0.3685
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0038 0.0258 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0195 0.1597 0.1759
Schistosoma mansoni hypothetical protein 0.0063 0.0465 0.1093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0089 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0579 0.4893 0.4893
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0063 0.0465 0.0465
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0251 0.2077 0.2555
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0063 0.0465 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0089 0.069 0.5467
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0412 0.3267
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0089 0.058
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0038 0.0258 0.4712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0021 0.014
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0067 0.0534
Mycobacterium ulcerans oxidoreductase 0.0038 0.0258 0.0218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0289
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.03 0.0704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0038 0.0258 0.0218
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0063 0.0465 0.3685
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0039 0.0264 0.0396
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0074
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0038 0.0258 0.0218
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0548 0.1288
Loa Loa (eye worm) hypothetical protein 0.0179 0.1466 0.1654
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0156 0.1262 0.2259
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0197 0.0347
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.062 0.5242 0.6623
Brugia malayi Cathepsin L-like precursor 0.0016 0.0067 0.0067
Schistosoma mansoni [ACP] S-malonyltransferase 0.0039 0.0264 0.062
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0038 0.0258 0.0218
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0021 0.0021
Toxoplasma gondii type I fatty acid synthase, putative 0.0441 0.3711 0.6657
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0197 0.022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0197 0.0464
Toxoplasma gondii cathepsin CPL 0.0016 0.0067 0.0114
Echinococcus granulosus cathepsin l1 0.0016 0.0067 0.0158
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0067 0.0067
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.062 0.5242 0.6547
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0411 0.0732
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0067 0.0158
Trypanosoma brucei unspecified product 0.0013 0.0039 0.0308
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0063 0.0465 0.0465
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0038 0.0258 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0038 0.0258 0.0218
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0004 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Schistosoma mansoni [ACP] S-malonyltransferase 0.0039 0.0264 0.062
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0067 0.0101
Mycobacterium ulcerans quinone oxidoreductase 0.0038 0.0258 0.0218
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1961 0.2212
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0004 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0548 0.3586
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0156 0.1262 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0067 0.0158
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0039 0.0264 0.209
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0197 0.1563
Echinococcus granulosus geminin 0.0505 0.4256 1
Leishmania major zinc binding dehydrogenase-like protein 0.0038 0.0258 0.1306
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0269 0.1251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0289
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0156 0.1262 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0067 0.0534
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0197 0.0296
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0067 0.0067
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0402 0.3375 0.6055
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0089 0.0089
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0548 0.1288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0006
Toxoplasma gondii acyl carrier protein ACP 0.0063 0.0465 0.0828
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0658 0.5572 0.7047
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0063 0.0465 0.0484
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0095 0.0743 0.0841
Leishmania major acyl carrier protein, putative 0.0063 0.0465 0.272
Brugia malayi cathepsin L-like precursor 0.0011 0.0021 0.0021
Loa Loa (eye worm) acyl carrier protein 0.0063 0.0465 0.0523
Mycobacterium ulcerans thioesterase TesA 0.0516 0.4356 0.5484
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0258 0.0218
Leishmania major cathepsin L-like protease 0.0062 0.0458 0.2674
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0548 0.0823
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0063 0.0465 0.0484
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0063 0.0465 0.0484
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0289
Brugia malayi MH1 domain containing protein 0.0016 0.0067 0.0067
Mycobacterium ulcerans Type I modular polyketide synthase 0.062 0.5242 0.6623
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0005
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.03 0.0531
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0313 0.2614 0.4687
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0269 0.213
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0507 0.4274 0.5378
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0038 0.0258 0.0457
Onchocerca volvulus 0.0028 0.0167 0.0171
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1466 0.1539
Treponema pallidum acyl carrier protein 0.0063 0.0465 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0548 0.3586
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0156 0.1262 0.1508
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0156 0.1262 0.8173
Schistosoma mansoni smad1 5 8 and 0.0016 0.0067 0.0157
Onchocerca volvulus 0.0016 0.0067 0.0067
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0067 0.01
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0038 0.0258 0.2047
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0089 0.0208
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0038 0.0258 0.0388
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0197 0.0296
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0197 0.0296
Toxoplasma gondii quinone oxidoreductase, putative 0.0038 0.0258 0.0457
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0548 0.3586
Leishmania major cathepsin L-like protease 0.0062 0.0458 0.2674
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0548 0.4345
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.0295
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.03 0.1961
Mycobacterium ulcerans polyketide synthase Pks9 0.041 0.3442 0.431
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0063 0.0465 0.0484
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0063 0.0465 0.0484
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0548 0.0823
Plasmodium vivax vivapain-2 0.0016 0.0067 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0156 0.1262 1
Brugia malayi MH1 domain containing protein 0.0016 0.0067 0.0067
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0067 0.0067
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0063 0.0465 0.0484
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0039 0.0264 0.062
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0038 0.0258 0.0218
Brugia malayi Cathepsin L-like precursor 0.0011 0.0021 0.0021
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0089 0.1617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium ulcerans polyketide synthase MbtC 0.0156 0.1262 0.1508
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.03 0.0531
Brugia malayi Cathepsin L-like precursor 0.0016 0.0067 0.0067
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0063 0.0465 0.0484
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0038 0.0258 0.0218
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.3327 0.4991
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0197 0.1563
Loa Loa (eye worm) Smad1 0.0016 0.0067 0.0073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0067 0.0101
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0039 0.0264 0.209
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0067 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0039 0.0308
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0063 0.0465 0.0698
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0156 0.1262 0.2965
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0063 0.0465 0.0484
Schistosoma mansoni hypothetical protein 0.0505 0.4256 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0067 0.0157
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0658 0.5572 0.7047
Schistosoma mansoni cpg binding protein 0.0029 0.0181 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0039 0.0308
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.041 0.3442 0.4183
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0345 0.2733
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0038 0.0258 0.2047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Brugia malayi Methyltransferase-like protein 4 0.0187 0.1529 0.1529
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0548 0.3191
Echinococcus multilocularis AMP dependent ligase 0.0063 0.0465 0.0698
Toxoplasma gondii type I fatty acid synthase, putative 0.0658 0.5572 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0197 0.1563
Echinococcus granulosus dna polymerase eta 0.0019 0.0089 0.0208
Onchocerca volvulus 0.0038 0.0258 0.0268
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0197 0.014
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0458 0.3632
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0445 0.3745 0.4699
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0038 0.0258 0.2047
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0038 0.0258 0.0218
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0579 0.4893 0.5525
Leishmania major DNA polymerase eta, putative 0.0019 0.0089 0.0145
Echinococcus granulosus NADH dehydrogenase 0.0063 0.0465 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0021 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0063 0.0465 0.0484
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.062 0.5242 0.6547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Echinococcus multilocularis cysteine protease 0.0016 0.0067 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0039 0.0308
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0004 0.0004
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0038 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0505 0.4256 1
Plasmodium falciparum acyl carrier protein 0.0063 0.0465 0.3685
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0658 0.5572 0.7047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Toxoplasma gondii acyl transferase domain-containing protein 0.0039 0.0264 0.0466
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0548 0.0548
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0658 0.5572 0.7047
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0197 0.0888
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0548 0.0823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0003
Leishmania major hypothetical protein, conserved 0.0039 0.0264 0.1343
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0067 0.0158
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0038 0.0258 0.169
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0063 0.0465 0.3685
Trypanosoma cruzi acyl transferase-like protein, putative 0.0039 0.0264 0.209
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0063 0.0465 0.0484
Echinococcus granulosus dnaJ subfamily B 0.0396 0.3327 0.7816
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0063 0.0465 0.0523
Brugia malayi MH2 domain containing protein 0.0016 0.0067 0.0067
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0038 0.0258 0.0258
Onchocerca volvulus 0.0063 0.0465 0.0485
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0499 0.4204 0.5183
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0063 0.0465 0.2059
Schistosoma mansoni hypothetical protein 0.0396 0.3327 0.7816
Mycobacterium tuberculosis Hypothetical protein 0.0187 0.1529 0.1851
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0197 0.0347
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0089 0.0703
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0156 0.1262 0.1423
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0089 0.0133
Trypanosoma cruzi oxidoreductase, putative 0.0038 0.0258 0.2047
Echinococcus granulosus smad 0.0016 0.0067 0.0157
Loa Loa (eye worm) fibroinase 0.0016 0.0067 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0089 0.0098
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0213 0.1755 0.2141
Onchocerca volvulus 0.0038 0.0258 0.0268
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0038 0.0258 0.2047
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0067 0.0074
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0038 0.0258 0.0218
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0095 0.0743 0.0637
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0197 0.0464
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.03 0.2376
Loa Loa (eye worm) hypothetical protein 0.0347 0.2905 0.328
Brugia malayi Cathepsin L-like precursor 0.0011 0.0021 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0434 0.1021
Leishmania major d-xylulose reductase, putative 0.0038 0.0258 0.1306
Brugia malayi Cathepsin L-like precursor 0.0016 0.0067 0.0067
Leishmania major oxidoreductase, putative 0.0038 0.0258 0.1306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0458 0.3632
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0601 0.5079 0.6413
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.6665 1
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0039 0.0264 0.0225
Brugia malayi N-terminal motif family protein 0.0179 0.1466 0.1466
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0499 0.4204 0.5288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0063 0.0465 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0038 0.0258 0.1306
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.03 0.1961
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0038 0.0258 0.2047
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0009
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0926 0.787 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0458 0.3632
Mycobacterium ulcerans quinone reductase Qor 0.0038 0.0258 0.0218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Trypanosoma brucei oxidoreductase, putative 0.0038 0.0258 0.2047
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.069 0.5467
Brugia malayi hypothetical protein 0.0009 0.0004 0.0004
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0067 0.0067
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0089 0.0208
Mycobacterium ulcerans oxidoreductase 0.0038 0.0258 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0067 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0038 0.0258 0.0218
Mycobacterium ulcerans Type I modular polyketide synthase 0.062 0.5242 0.6623
Trypanosoma brucei unspecified product 0.0013 0.0039 0.0308
Schistosoma mansoni dep domain containing protein 0.0009 0.0004 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.041 0.3442 0.431
Schistosoma mansoni [ACP] S-malonyltransferase 0.0039 0.0264 0.062
Mycobacterium ulcerans polyketide synthase Pks13 0.0926 0.787 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0458 0.3632
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0067 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0465 0.8481
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0004 0.0006
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0009
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0038 0.0258 0.0218
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0156 0.1262 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Echinococcus granulosus AMP dependent ligase 0.0063 0.0465 0.1093
Trypanosoma brucei acyl transferase-like protein 0.0039 0.0264 0.209
Loa Loa (eye worm) hypothetical protein 0.0095 0.0743 0.0837
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0579 0.4893 0.6174
Schistosoma mansoni cpg binding protein 0.0028 0.0167 0.0392
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0067 0.0157
Echinococcus granulosus dna polymerase kappa 0.0019 0.0089 0.0208
Leishmania major nuclear receptor binding factor-like protein 0.0038 0.0258 0.1306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Loa Loa (eye worm) hypothetical protein 0.0072 0.0548 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Loa Loa (eye worm) cysteine protease 0.0016 0.0067 0.0074
Echinococcus multilocularis geminin 0.0505 0.4256 0.6386
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0038 0.0258 0.0289
Plasmodium vivax vivapain-2 0.0016 0.0067 0.0534
Leishmania major cathepsin L-like protease 0.0062 0.0458 0.2674
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0067 0.0074
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0156 0.1262 0.1508
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0067 0.123
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0465 0.0484
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0004 0.0002
Loa Loa (eye worm) acyl carrier protein 0.0285 0.2372 0.2677
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0063 0.0465 0.0484
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0089 0.0089
Mycobacterium ulcerans polyketide synthase 0.062 0.5242 0.6623
Mycobacterium tuberculosis Probable thioesterase TesA 0.0516 0.4356 0.5484
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0465 0.8481
Onchocerca volvulus 0.0016 0.0067 0.0067
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0197 0.1563
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0063 0.0465 0.0484
Mycobacterium ulcerans acyl carrier protein 0.0063 0.0465 0.0484
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0089 0.0145
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1961 0.2212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Schistosoma mansoni smad 0.0016 0.0067 0.0157
Trypanosoma brucei oxidoreductase, putative 0.0038 0.0258 0.2047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0156 0.1262 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Mycobacterium leprae Probable polyketide synthase Pks1 0.0658 0.5572 0.6981
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0269 0.4903
Onchocerca volvulus 0.0016 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0022
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0006
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0038 0.0258 0.0218
Echinococcus multilocularis dna polymerase eta 0.0019 0.0089 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0038 0.0258 0.2047
Loa Loa (eye worm) ctsf protein 0.0016 0.0067 0.0074
Mycobacterium ulcerans short-chain dehydrogenase 0.0038 0.0258 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0458 0.3632
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0548 0.1288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0067 0.0441
Leishmania major quinone oxidoreductase, putative 0.0038 0.0258 0.1306
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0039 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0067 0.0441
Loa Loa (eye worm) acetyltransferase 0.0147 0.1192 0.1343
Loa Loa (eye worm) fatty acid synthase 0.0612 0.5171 0.5839
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0089 0.0703
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0038 0.0258 0.0607
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0067 0.0157
Mycobacterium ulcerans thioesterase 0.0516 0.4356 0.5484
Trypanosoma cruzi oxidoreductase, putative 0.0038 0.0258 0.2047
Brugia malayi Cathepsin L-like precursor 0.0016 0.0067 0.0067
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0067 0.0158
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0548 0.4345
Mycobacterium ulcerans quinone oxidoreductase 0.0038 0.0258 0.0218
Brugia malayi MH2 domain containing protein 0.0237 0.1961 0.1961

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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