Detailed information for compound 1539854

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.442 | Formula: C24H22N2O4
  • H donors: 0 H acceptors: 2 LogP: 5.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc2n(c1)c(Cc1ccccc1)c(n2)c1ccc(c(c1)OC)OC
  • InChi: 1S/C24H22N2O4/c1-28-20-11-9-17(14-21(20)29-2)23-19(13-16-7-5-4-6-8-16)26-15-18(24(27)30-3)10-12-22(26)25-23/h4-12,14-15H,13H2,1-3H3
  • InChiKey: KJQYNAPRNVKYDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0016
Echinococcus granulosus cathepsin b 0.0281 0.3108 0.4106
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0242 0.0779
Plasmodium vivax serine-repeat antigen (SERA) 0.0012 0.0058 0.1752
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0182 0.0487
Plasmodium falciparum importin beta, putative 0.0032 0.0277 0.829
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0104 0.0335
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Echinococcus multilocularis cathepsin b 0.0281 0.3108 0.3104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Plasmodium falciparum serine repeat antigen 5 0.0012 0.0058 0.1626
Brugia malayi cathepsin L-like precursor 0.0012 0.0058 0.0188
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.014 0.0185
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0014 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.014 0.045
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0333 0.0434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.0858 0.113
Entamoeba histolytica hypothetical protein 0.0083 0.0858 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Entamoeba histolytica cysteine proteinase 1, putative 0.0019 0.014 0.1578
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0077 0.4433
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0012 0.0058 0.1752
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0166 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Schistosoma mansoni Smad4 0.0008 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0248 0.2729 0.7285
Schistosoma mansoni DNA polymerase eta 0.0022 0.0166 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Brugia malayi MH1 domain containing protein 0.001 0.0036 0.0116
Echinococcus granulosus microtubule associated protein 2 0.0674 0.756 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0014 0.0029
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.014 0.045
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0265 0.2606
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0242 0.7268
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0083
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.2729 0.2725
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0016
Onchocerca volvulus Cathepsin F homolog 0.0019 0.014 0.0449
Schistosoma mansoni Smad4 0.0008 0.0014 0.0018
Schistosoma mansoni ferritin light chain 0.0009 0.0024 0.0032
Schistosoma mansoni hypothetical protein 0.0013 0.0064 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1625 0.2144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0135 0.013
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Loa Loa (eye worm) nuclear factor I 0.001 0.0036 0.0097
Plasmodium falciparum cysteine proteinase falcipain 1 0.0019 0.014 0.4103
Brugia malayi isocitrate dehydrogenase 0.0019 0.0135 0.0435
Brugia malayi TAR-binding protein 0.0072 0.0737 0.237
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.014 0.045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0166 0.1891
Trypanosoma brucei cysteine peptidase C (CPC) 0.0095 0.1001 1
Schistosoma mansoni cathepsin C 0.0012 0.0058 0.0077
Giardia lamblia Cathepsin L precursor 0.0012 0.0058 0.0536
Leishmania major GTP-binding protein, putative 0.0023 0.0182 0.1781
Leishmania major DNA polymerase eta, putative 0.0022 0.0166 0.1619
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0005 0.0016
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Trichomonas vaginalis ran, putative 0.0023 0.0182 0.1781
Echinococcus multilocularis lamin 0.0031 0.0265 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.014 0.045
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.014 0.045
Brugia malayi MH2 domain containing protein 0.0275 0.3037 0.9773
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.0974
Entamoeba histolytica cysteine protease, putative 0.0012 0.0058 0.0625
Echinococcus multilocularis cpg binding protein 0.003 0.0255 0.025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0182 0.0587
Brugia malayi Muscleblind-like protein 0.0146 0.1573 0.5061
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.014 0.045
Trichomonas vaginalis ferritin, putative 0.0009 0.0024 0.019
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Brugia malayi hypothetical protein 0.0248 0.2729 0.8781
Brugia malayi Pax transcription factor protein 2 0.0272 0.3008 0.9679
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0012 0.0058 0.1752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0265 0.3042
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0005 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0166 0.1619
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0212
Trypanosoma brucei unspecified product 0.0022 0.0166 0.1619
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0077 0.0718
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0012 0.0058 0.1626
Giardia lamblia Cathepsin B precursor 0.0095 0.1001 1
Giardia lamblia Hypothetical protein 0.0012 0.0058 0.0536
Loa Loa (eye worm) hypothetical protein 0.0031 0.0265 0.0707
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Giardia lamblia Cathepsin L precursor 0.0012 0.0058 0.0536
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0064 0.0078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Brugia malayi Cytochrome P450 family protein 0.0014 0.0077 0.0246
Echinococcus multilocularis cysteine protease 0.0019 0.014 0.0135
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1573 0.1569
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0333 0.3294
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0089 0.0848
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.0974
Echinococcus granulosus Smad4 0.0019 0.0131 0.0167
Schistosoma mansoni ferritin 0.0009 0.0024 0.0032
Schistosoma mansoni cpg binding protein 0.0028 0.0237 0.0313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0166 0.0535
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0005 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Plasmodium vivax unspecified product 0.0012 0.0058 0.1752
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0265 0.7941
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0281 0.3108 0.411
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0135 0.013
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0012 0.0058 0.1752
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0012 0.0058 0.1752
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0135 0.013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.014 0.4103
Entamoeba histolytica hypothetical protein 0.0083 0.0858 1
Schistosoma mansoni smad1 5 8 and 0.0019 0.0131 0.0173
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0058 0.0188
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0005 0.0007
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0095 0.1001 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0135 0.1305
Echinococcus granulosus cysteine protease 0.0019 0.014 0.0178
Loa Loa (eye worm) Smad1 0.0019 0.0131 0.035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0166 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0281 0.3108 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Leishmania major importin beta-1 subunit, putative 0.0026 0.0209 0.2051
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0005 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Echinococcus granulosus flap endonuclease 1 0.0031 0.0265 0.0344
Schistosoma mansoni hypothetical protein 0.007 0.0712 0.0941
Echinococcus granulosus muscleblind protein 0.0146 0.1573 0.2075
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0135 0.0435
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.1625 0.5229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3108 0.411
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0166 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0077 0.0204
Brugia malayi Cathepsin L-like precursor 0.0019 0.014 0.045
Schistosoma mansoni hypothetical protein 0.007 0.0712 0.0941
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0005 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.0974
Schistosoma mansoni ferritin 0.0009 0.0024 0.0032
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0005 0.0016
Loa Loa (eye worm) transcription factor SMAD2 0.0275 0.3037 0.8109
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0737 0.0732
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.014 0.0135
Brugia malayi Cathepsin L-like precursor 0.0019 0.014 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0166 0.1619
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0016
Brugia malayi hypothetical protein 0.0083 0.0858 0.2762
Leishmania major hypothetical protein, conserved 0.0029 0.0242 0.2381
Trypanosoma cruzi cysteine protease, putative 0.0019 0.014 0.045
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0135 0.4052
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0012 0.0058 0.0077
Plasmodium vivax vivapain-3 0.0019 0.014 0.4192
Giardia lamblia DINP protein human, muc B family 0.0022 0.0166 0.1619
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0016
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0012 0.0058 0.1752
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Onchocerca volvulus 0.0019 0.014 0.0449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Entamoeba histolytica hypothetical protein 0.0083 0.0858 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0712 0.229
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0077 0.0204
Giardia lamblia Hypothetical protein 0.0012 0.0058 0.0536
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0058 0.0077
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.014 0.0178
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0005 0.0016
Plasmodium falciparum serine repeat antigen 2 0.0012 0.0058 0.1626
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0012 0.0058 0.0536
Echinococcus granulosus snurportin 1 0.0337 0.3746 0.4951
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0131 0.0126
Onchocerca volvulus 0.0019 0.014 0.0449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0265 0.0707
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0058 0.0077
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.0058 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0058 0.0188
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0005 0.015
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0058 0.0625
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0281 0.3108 0.8297
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0005 0.0016
Giardia lamblia Cysteine protease 0.0012 0.0058 0.0536
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0005 0.0016
Echinococcus granulosus lamin 0.0031 0.0265 0.0344
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0012 0.0058 0.0625
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Entamoeba histolytica cysteine protease, putative 0.0012 0.0058 0.0625
Loa Loa (eye worm) MH2 domain-containing protein 0.0275 0.3037 0.8109
Plasmodium vivax serine-repeat antigen (SERA) 0.0012 0.0058 0.1752
Schistosoma mansoni apoferritin-2 0.0009 0.0024 0.0032
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0135 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Entamoeba histolytica hypothetical protein 0.0083 0.0858 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0012 0.0058 0.0536
Schistosoma mansoni cpg binding protein 0.003 0.0255 0.0337
Brugia malayi cathepsin L-like cysteine proteinase 0.0012 0.0058 0.0188
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0012 0.0058 0.1626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0166 0.1619
Loa Loa (eye worm) dehydrogenase 0.0008 0.0005 0.0013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0135 0.0361
Onchocerca volvulus 0.0028 0.0237 0.0772
Echinococcus granulosus tar DNA binding protein 0.0072 0.0737 0.0968
Brugia malayi RNA binding protein 0.0072 0.0737 0.237
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0024 0.1174
Toxoplasma gondii cathepsin CPL 0.0019 0.014 0.1352
Loa Loa (eye worm) hypothetical protein 0.0221 0.2425 0.6474
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Plasmodium vivax unspecified product 0.0019 0.014 0.4192
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0012 0.0058 0.0536
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.014 0.0185
Schistosoma mansoni cathepsin S (C01 family) 0.0012 0.0058 0.0077
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0237 0.0632
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0005 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Schistosoma mansoni ferritin 0.0009 0.0024 0.0032
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0166 0.1619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1625 0.2144
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0166 0.1619
Schistosoma mansoni ferritin light chain 0.0009 0.0024 0.0032
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0209 0.0674
Brugia malayi fibroinase precursor 0.0012 0.0058 0.0188
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0036
Trypanosoma cruzi major cysteine proteinase, putative 0.0012 0.0058 0.0188
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0277 0.2731
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0014 0.0011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0135 0.0172
Onchocerca volvulus 0.0019 0.014 0.0449
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Plasmodium falciparum serine repeat antigen 9 0.0012 0.0058 0.1626
Schistosoma mansoni hypothetical protein 0.0151 0.1632 0.2158
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.756 0.7559
Schistosoma mansoni survival motor neuron protein 0.0051 0.0492 0.0651
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Entamoeba histolytica cysteine proteinase 2 0.0019 0.014 0.1578
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0086 0.0081
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0333 0.1072
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0086 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Echinococcus granulosus importin subunit beta 1 0.0032 0.0277 0.036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0712 0.0707
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni ferritin 0.0009 0.0024 0.0032
Echinococcus granulosus dnaJ subfamily B 0.0399 0.4448 0.5881
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0712 0.0707
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0005 0.0016
Echinococcus multilocularis expressed protein 0.0009 0.0024 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0058 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0058 0.0178
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0182 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Loa Loa (eye worm) hypothetical protein 0.0146 0.1573 0.4199
Leishmania major hypothetical protein, conserved 0.0037 0.0333 0.3294
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0242 0.2381
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0182 0.5476
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0265 0.2606
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0058 0.0077
Onchocerca volvulus 0.0051 0.0492 0.1621
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3108 0.411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Loa Loa (eye worm) hypothetical protein 0.0151 0.1632 0.4357
Plasmodium vivax vivapain-1 0.0019 0.014 0.4192
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0012 0.0058 0.0188
Onchocerca volvulus 0.0019 0.014 0.0449
Schistosoma mansoni hypothetical protein 0.0384 0.4272 0.565
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0265 0.0852
Echinococcus granulosus dna polymerase eta 0.0022 0.0166 0.0214
Giardia lamblia Cathepsin L precursor 0.0012 0.0058 0.0536
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0012 0.0058 0.1752
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0265 0.2606
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.014 0.0185
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.756 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0131 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.014 0.1578
Plasmodium vivax importin-beta 2, putative 0.0032 0.0277 0.8316
Brugia malayi cathepsin L precursor 0.0012 0.0058 0.0188
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0209 0.2051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0058 0.0536
Brugia malayi Cathepsin L-like precursor 0.0019 0.014 0.045
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0005 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0077 0.0246
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.3746 1
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.1632 0.5251
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0242 0.7226
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0166 0.022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0135 0.013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0135 0.013
Plasmodium falciparum serine repeat antigen 4 0.0012 0.0058 0.1626
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Schistosoma mansoni Smad4 0.0019 0.0131 0.0173
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.014 0.4103
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Giardia lamblia Cathepsin L precursor 0.0012 0.0058 0.0536
Toxoplasma gondii cathepsin CPC2 0.0012 0.0058 0.0536
Brugia malayi Cathepsin L-like precursor 0.0012 0.0058 0.0188
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0005 0.0016
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0333 0.0328
Giardia lamblia Cathepsin B precursor 0.0012 0.0058 0.0536
Brugia malayi hypothetical protein 0.0018 0.0128 0.041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Giardia lamblia Cathepsin L-like protease 0.0012 0.0058 0.0536
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0005 0.0016
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Giardia lamblia Cathepsin B precursor 0.0012 0.0058 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0012 0.0058 0.0536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0166 0.0535
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0005 0.0016
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0024 1
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni ran 0.0023 0.0182 0.0241
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0058 0.0536
Brugia malayi CXXC zinc finger family protein 0.0028 0.0237 0.0762
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0058 0.0536
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.014 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0135 0.8059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Plasmodium falciparum serine repeat antigen 6 0.0012 0.0058 0.1626
Echinococcus multilocularis ferritin 0.0009 0.0024 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.2425 0.7803
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0089 0.0848
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0012 0.0058 0.0077
Echinococcus multilocularis Smad4 0.0019 0.0131 0.0126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0166 0.0444
Schistosoma mansoni ran 0.0023 0.0182 0.0241
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.014 0.0373
Brugia malayi hypothetical protein 0.0008 0.0005 0.0016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0182 0.0587
Brugia malayi oxidoreductase 0.0008 0.0005 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.014 0.1578
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.014 0.1578
Echinococcus granulosus cathepsin L 0.0019 0.014 0.0178
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0012 0.0058 0.0536
Echinococcus granulosus dna polymerase kappa 0.0022 0.0166 0.0214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Plasmodium vivax vivapain-2 0.0019 0.014 0.4192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1625 0.1621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Schistosoma mansoni smad1 5 8 and 0.0019 0.0131 0.0173
Brugia malayi hypothetical protein 0.0008 0.0005 0.0016
Toxoplasma gondii cathepsin CPC1 0.0012 0.0058 0.0536
Brugia malayi MH1 domain containing protein 0.0019 0.0131 0.0422
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0166 0.0535
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0014 0.0009
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0135 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0058 0.0536
Giardia lamblia Cathepsin L precursor 0.0012 0.0058 0.0536
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.014 0.0185
Brugia malayi Smad1 0.0019 0.0131 0.0422
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0014 0.0011
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0058 0.0077
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Schistosoma mansoni intermediate filament proteins 0.0031 0.0265 0.035
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0131 0.0167
Brugia malayi Cytochrome P450 family protein 0.0014 0.0077 0.0246
Echinococcus granulosus lamin dm0 0.0031 0.0265 0.0344
Echinococcus granulosus ferritin 0.0009 0.0024 0.0025
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.014 0.045
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Giardia lamblia Encystation-specific protease 0.0012 0.0058 0.0536
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0333 0.3294
Plasmodium falciparum serine repeat antigen 3 0.0012 0.0058 0.1626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1625 0.2149
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Entamoeba histolytica hypothetical protein 0.0012 0.0058 0.0625
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0333 1
Trypanosoma brucei unspecified product 0.0015 0.0089 0.0848
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0058 0.0188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Schistosoma mansoni cathepsin B (C01 family) 0.0012 0.0058 0.0077
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Brugia malayi Cathepsin L-like precursor 0.0019 0.014 0.045
Plasmodium falciparum serine repeat antigen 1 0.0012 0.0058 0.1626
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0265 0.0852
Brugia malayi Latrophilin receptor protein 2 0.007 0.0712 0.229
Loa Loa (eye worm) RNA binding protein 0.0072 0.0737 0.1967
Trypanosoma brucei unspecified product 0.0015 0.0089 0.0848
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0005 0.0016
Brugia malayi MH2 domain containing protein 0.0019 0.0131 0.0422
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.2425 0.7803
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0064 0.0059
Brugia malayi Importin beta-1 subunit 0.0032 0.0277 0.0892
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0135 0.1305
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0166 1
Brugia malayi hypothetical protein 0.0029 0.0242 0.0779
Loa Loa (eye worm) ctsf protein 0.0019 0.014 0.0373
Schistosoma mansoni hypothetical protein 0.0337 0.3746 0.4954
Schistosoma mansoni flap endonuclease-1 0.0028 0.0231 0.0306
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0737 0.1967
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0005 0.0016
Brugia malayi RNA, U transporter 1 0.009 0.0938 0.3019
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0012 0.0058 0.0536
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0277 0.0272
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Echinococcus multilocularis smad 0.0019 0.0131 0.0126
Entamoeba histolytica cysteine protease, putative 0.0012 0.0058 0.0625
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0131 0.035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0058 0.0536
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni hypothetical protein 0.007 0.0712 0.0941
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.0974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Schistosoma mansoni smad 0.0019 0.0131 0.0173
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0058 0.0188
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0593 0.0785
Brugia malayi Augmenter of liver regeneration 0.0037 0.0333 0.1072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.014 0.0135
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.014 0.0373
Giardia lamblia Cathepsin B precursor 0.0095 0.1001 1
Echinococcus granulosus geminin 0.0384 0.4272 0.5648
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0058 0.0536
Onchocerca volvulus 0.0012 0.0058 0.0178
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.014 0.0178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0166 0.0535
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.0974
Brugia malayi MH2 domain containing protein 0.0019 0.0131 0.0422
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0135 0.1305
Onchocerca volvulus 0.0019 0.014 0.0449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0014 0.0009
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0012 0.0058 0.1752
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Loa Loa (eye worm) cysteine protease 0.0019 0.014 0.0373
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.0858 0.0854
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0016
Plasmodium vivax vivapain-2 0.0019 0.014 0.4192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0166 0.0535
Brugia malayi Cathepsin L-like precursor 0.0019 0.014 0.045
Giardia lamblia Cathepsin B precursor 0.0012 0.0058 0.0536
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0166 0.1619
Echinococcus granulosus GPCR family 2 0.007 0.0712 0.0935
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0399 0.4448 0.5883
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0333 0.089
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0265 0.0707
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0012 0.0058 0.1752
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Schistosoma mansoni importin beta-1 0.0032 0.0277 0.0367
Loa Loa (eye worm) hypothetical protein 0.0015 0.0086 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Onchocerca volvulus Cathepsin L homolog 0.0019 0.014 0.0449
Echinococcus multilocularis geminin 0.0384 0.4272 0.4269
Plasmodium falciparum serine repeat antigen 8 0.0012 0.0058 0.1626
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0135 0.0435
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0014 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0166 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0521 0.518
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0012 0.0058 0.1752
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0012 0.0058 0.0536
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3108 0.411
Onchocerca volvulus 0.0031 0.0265 0.0865
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0097
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0012 0.0058 0.1626
Leishmania major cysteine peptidase A (CPA) 0.0019 0.014 0.1352
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0095 0.1001 0.3223
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.2425 0.6474
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0166 0.0535
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.014 0.045
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0182 0.0235
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0024 0.5
Echinococcus multilocularis cysteine protease 0.0019 0.014 0.0135
Loa Loa (eye worm) dehydrogenase 0.0008 0.0005 0.0013
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.014 0.045
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Brugia malayi intermediate filament protein 0.0031 0.0265 0.0852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0012 0.0058 0.0188
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0242 0.2381
Trypanosoma cruzi cruzipain precursor, putative 0.0019 0.014 0.045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0712 0.0935
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0209 0.2051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1625 0.2149
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0712 0.19
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0242 0.0779
Echinococcus granulosus cathepsin l1 0.0012 0.0058 0.0071
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0135 0.3962
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0131 0.0126
Entamoeba histolytica cysteine protease, putative 0.0012 0.0058 0.0625
Echinococcus granulosus expressed protein 0.0009 0.0024 0.0025
Echinococcus multilocularis musashi 0.0031 0.0265 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0058 0.0536
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0182 0.1781
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.4448 0.4445
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0712 0.0935
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.014 0.1578
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0131 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus multilocularis muscleblind protein 0.0146 0.1573 0.1569
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Trypanosoma cruzi major cysteine proteinase, putative 0.0012 0.0058 0.0188
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0166 0.0161
Echinococcus granulosus cathepsin l1 0.0019 0.014 0.0178
Schistosoma mansoni hypothetical protein 0.0083 0.0858 0.1135
Echinococcus multilocularis cathepsin b 0.0281 0.3108 0.3104
Schistosoma mansoni hypothetical protein 0.0051 0.0492 0.0651
Loa Loa (eye worm) hypothetical protein 0.0032 0.0277 0.074
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0209 0.2051
Echinococcus multilocularis snurportin 1 0.0337 0.3746 0.3742
Onchocerca volvulus 0.0272 0.3008 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.014 0.0185
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.0858 0.1135
Giardia lamblia Cathepsin L-like protease 0.0012 0.0058 0.0536
Brugia malayi Cathepsin L-like precursor 0.0019 0.014 0.045
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0166 0.1619
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus multilocularis cathepsin L 0.0012 0.0058 0.0053
Giardia lamblia Cathepsin B precursor 0.0012 0.0058 0.0536
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0012 0.0058 0.0625
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.014 0.045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0166 0.0444
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0008 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.007 0.0712 0.0941
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0212
Echinococcus granulosus cathepsin b 0.0281 0.3108 0.4106
Schistosoma mansoni smad 0.0008 0.0014 0.0018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0166 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0373
Brugia malayi MH1 domain containing protein 0.0019 0.0131 0.0422
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.014 0.1578
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.014 0.4103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus granulosus intermediate filament protein 0.0031 0.0265 0.0344
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0333 0.1072
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0333 0.1072
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0058 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0058 0.0536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1625 0.2149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0058 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.1001 1
Onchocerca volvulus 0.0031 0.0265 0.0865
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.2729 0.3605
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0104 0.0278
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0492 0.1583
Brugia malayi Cathepsin L-like precursor 0.0012 0.0058 0.0188
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Giardia lamblia Cathepsin B precursor 0.0012 0.0058 0.0536
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0058 0.0077
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0024 0.1174
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0005 0.0016
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0024 0.1174
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0265 0.0707
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0005 0.0007
Plasmodium falciparum flap endonuclease 1 0.0031 0.0265 0.7909
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0051
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Onchocerca volvulus 0.0019 0.014 0.0449
Leishmania major cathepsin L-like protease 0.0019 0.014 0.1352
Entamoeba histolytica Ran family GTPase 0.0023 0.0182 0.208
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.1001 0.1325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1625 0.1621
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.014 0.0178
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0737 0.237
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0166 0.0161
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0135 0.1305
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0737 0.1967
Loa Loa (eye worm) hypothetical protein 0.007 0.0712 0.19
Giardia lamblia Cysteine protease 0.0012 0.0058 0.0536
Echinococcus multilocularis GPCR, family 2 0.007 0.0712 0.0707
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0012 0.0058 0.0536
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0265 0.2606
Loa Loa (eye worm) hypothetical protein 0.0146 0.1573 0.4199
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0012 0.0058 0.0536
Schistosoma mansoni apoferritin-2 0.0009 0.0024 0.0032
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0005 0.0016
Echinococcus multilocularis lamin dm0 0.0031 0.0265 0.026
Schistosoma mansoni smad1 5 8 and 0.0019 0.0131 0.0173
Leishmania major cytochrome p450-like protein 0.0014 0.0077 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0089 0.0848
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.1625 0.4339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0156
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0333 0.3294
Onchocerca volvulus 0.0019 0.014 0.0449
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0005 0.0016
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0182 0.0178
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.014 0.0135
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0058 0.0156
Brugia malayi MH1 domain containing protein 0.001 0.0036 0.0116
Echinococcus granulosus smad 0.0019 0.0131 0.0167
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.014 0.1578
Brugia malayi Flap endonuclease-1 0.0031 0.0265 0.0852
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0277 0.2731
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0265 0.026
Plasmodium falciparum serine repeat antigen 7 0.0012 0.0058 0.1626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0058 0.0536
Giardia lamblia Cathepsin B precursor 0.0095 0.1001 1
Giardia lamblia Cysteine protease 0.0012 0.0058 0.0536
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0265 0.2606
Schistosoma mansoni hypothetical protein 0.0384 0.4272 0.565
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0242 0.7226
Entamoeba histolytica cysteine protease, putative 0.0012 0.0058 0.0625
Echinococcus granulosus cpg binding protein 0.003 0.0255 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0016
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.3008 0.8031
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0005 0.0007
Giardia lamblia Cathepsin L precursor 0.0012 0.0058 0.0536
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0012 0.0058 0.0156
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0017 0.0046
Onchocerca volvulus 0.0012 0.0058 0.0178
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0024 0.1174
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0007
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Giardia lamblia Cysteine protease 0.0012 0.0058 0.0536
Leishmania major DNA polymerase kappa, putative 0.0022 0.0166 0.1619
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0277 0.2731
Echinococcus multilocularis cathepsin L 0.0019 0.014 0.0135
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0166 0.0535
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0131 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.0242 0.0647
Loa Loa (eye worm) fibroinase 0.0019 0.014 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.014 0.1352
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0077 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.014 0.1352
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0014 0.0036
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0012 0.0058 0.1752
Entamoeba histolytica cysteine protease, putative 0.0012 0.0058 0.0625
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0005 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0058 0.0536
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.014 0.1352
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0281 0.3108 1
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.014 0.045
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0058 0.0188
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0024 1
Brugia malayi MH2 domain containing protein 0.0008 0.0014 0.0044
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0182 0.1781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0058 0.0077
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0058 0.0156
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0013
Entamoeba histolytica cysteine protease, putative 0.0019 0.014 0.1578
Schistosoma mansoni cpg binding protein 0.003 0.0255 0.0337
Entamoeba histolytica hypothetical protein 0.0026 0.0209 0.2394
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0077 0.0204
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0182 0.1781
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0182 0.5407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.014 0.1352
Echinococcus granulosus cathepsin L 0.0012 0.0058 0.0071
Toxoplasma gondii cathepsin B 0.0095 0.1001 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0135 0.0435
Loa Loa (eye worm) cathepsin B 0.0095 0.1001 0.2674
Schistosoma mansoni lamin 0.0031 0.0265 0.035
Onchocerca volvulus Cathepsin L homolog 0.0019 0.014 0.0449
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0007
Echinococcus multilocularis dna polymerase eta 0.0022 0.0166 0.0161
Schistosoma mansoni lamin 0.0031 0.0265 0.035
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0005 0.015
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0005 0.0016

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.