Detailed information for compound 1539858

Basic information

Technical information
  • TDR Targets ID: 1539858
  • Name: N-(2-methoxy-5-methylphenyl)-5-nitrofuran-2-c arboxamide
  • MW: 276.245 | Formula: C13H12N2O5
  • H donors: 1 H acceptors: 3 LogP: 2.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)c1ccc(o1)[N+](=O)[O-])C
  • InChi: 1S/C13H12N2O5/c1-8-3-4-10(19-2)9(7-8)14-13(16)11-5-6-12(20-11)15(17)18/h3-7H,1-2H3,(H,14,16)
  • InChiKey: JIYFACKBPOSVFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxy-5-methyl-phenyl)-5-nitro-furan-2-carboxamide
  • N-(2-methoxy-5-methylphenyl)-5-nitro-2-furancarboxamide
  • N-(2-methoxy-5-methyl-phenyl)-5-nitro-2-furamide
  • ZINC00447526
  • Oprea1_052834
  • STK062592

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.003 0.0072 0.0055
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0917 0.1321
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0119 0.0875 0.1262
Schistosoma mansoni methylthioadenosine phosphorylase 0.003 0.0072 0.0111
Brugia malayi Rhodanese-like domain containing protein 0.0119 0.0875 0.0906
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0167 0.0155
Schistosoma mansoni uridine phosphorylase 0.003 0.0072 0.0111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0167 0.0257
Brugia malayi MTAP 0.003 0.0072 0.0055
Echinococcus granulosus fatty acid amide hydrolase 1 0.01 0.0702 0.1082
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0401 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0167 0.0155
Schistosoma mansoni hypothetical protein 0.0073 0.0454 0.0699
Brugia malayi Bromodomain containing protein 0.0074 0.0465 0.0472
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0167 0.0257
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.013 0.097 0.15
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0167 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0401 0.0617
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0299 0.2496 0.3844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0167 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0018
Leishmania major nucleoside phosphorylase-like protein 0.003 0.0072 0.0082
Loa Loa (eye worm) uridine phosphorylase 0.003 0.0072 0.0055
Brugia malayi amidase 0.01 0.0702 0.0723
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1876 0.1967
Schistosoma mansoni coup transcription factor 0.0041 0.0167 0.0257
Echinococcus multilocularis fatty acid amide hydrolase 1 0.01 0.0702 0.1012
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.003 0.0072 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0631 0.0972
Loa Loa (eye worm) hypothetical protein 0.0299 0.2496 0.2625
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0167 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0167 0.0155
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0358 0.3025 0.3186
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0167 0.0155
Onchocerca volvulus 0.0119 0.0875 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.003 0.0072 0.0104
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0401 0.0403
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0167 0.0257
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.017 0.1335 0.4509
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0119 0.0875 0.2869
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0119 0.0171
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0103 0.0148
Schistosoma mansoni hypothetical protein 0.0034 0.0103 0.0158
Leishmania major methylthioadenosine phosphorylase, putative 0.003 0.0072 0.0082
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0329 0.0488
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0167 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0167 0.0155
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0341 0.2872 1
Brugia malayi nuclear receptor NHR-88 0.0041 0.0167 0.0155
Schistosoma mansoni microtubule-associated protein tau 0.0743 0.6494 1
Echinococcus granulosus geminin 0.0688 0.5997 0.9234
Echinococcus granulosus sterol regulatory element binding protein 0.0299 0.2496 0.3844
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0727 0.6349 0.9777
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0167 0.0155
Brugia malayi RNA binding protein 0.0067 0.0401 0.0403
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0167 0.0257
Toxoplasma gondii phosphorylase family protein 0.003 0.0072 0.0393
Schistosoma mansoni thyroid hormone receptor 0.0165 0.1284 0.1977
Schistosoma mansoni hypothetical protein 0.0034 0.0103 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0631 0.0972
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0436 0.0671
Brugia malayi CHE-14 protein 0.0299 0.2496 0.2625
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0727 0.6349 0.9149
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0329 0.0327
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.003 0.0072 0.0082
Trypanosoma cruzi nucleoside phosphorylase, putative 0.003 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0119 0.0875 0.0906
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.017 0.1335 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.013 0.097 0.7113
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0401 0.0577
Schistosoma mansoni methylthioadenosine phosphorylase 0.003 0.0072 0.0111
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0167 0.0241
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0167 0.0257
Echinococcus multilocularis protein dispatched 1 0.0299 0.2496 0.3597
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.097 0.15
Trichomonas vaginalis cdc25b, putative 0.0119 0.0875 0.2869
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0917 0.1412
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0167 0.0257
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0167 0.0257
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.003 0.0072 0.0082
Trypanosoma cruzi nucleoside phosphorylase, putative 0.003 0.0072 0.0082
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0727 0.6349 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.2496 0.3597
Echinococcus granulosus tar DNA binding protein 0.0067 0.0401 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0401 0.0617
Onchocerca volvulus 0.0119 0.0875 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0727 0.6349 0.6709
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.003 0.0072 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0167 0.0155
Echinococcus granulosus uridine phosphorylase 1 0.003 0.0072 0.0111
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.003 0.0072 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0167 0.0155
Entamoeba histolytica hypothetical protein 0.0071 0.0436 0.2882
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0072 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0167 0.0155
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0119 0.0875 0.1348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0631 0.0972
Schistosoma mansoni hypothetical protein 0.0024 0.0021 0.0032
Brugia malayi Rhodanese-like domain containing protein 0.0119 0.0875 0.0906
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0167 0.0257
Schistosoma mansoni hypothetical protein 0.0071 0.0436 0.0671
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0119 0.0183
Echinococcus granulosus fatty acid amide hydrolase 1 0.01 0.0702 0.1082
Entamoeba histolytica rodhanase-like domain containing protein 0.0119 0.0875 0.6363
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.003 0.0072 0.0052
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0917 0.1413
Toxoplasma gondii phosphorylase family protein 0.003 0.0072 0.0393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0631 0.091
Plasmodium vivax purine nucleoside phosphorylase, putative 0.017 0.1335 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.028 0.0275
Plasmodium falciparum purine nucleoside phosphorylase 0.017 0.1335 0.5
Brugia malayi hypothetical protein 0.1072 0.9453 1
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0167 0.0257
Schistosoma mansoni thyroid hormone receptor 0.0165 0.1284 0.1977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0167 0.0155
Entamoeba histolytica rodhanase-like domain containing protein 0.0119 0.0875 0.6363
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0167 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0436 0.0628
Brugia malayi steroid hormone receptor 0.0041 0.0167 0.0155
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1876 0.1967
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.013 0.097 0.1007
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0727 0.6349 0.6341
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0167 0.0257
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0917 0.0899
Mycobacterium leprae probable uridine phosphorylase 0.003 0.0072 1
Echinococcus multilocularis tumor protein p63 0.0364 0.3078 0.4435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0167 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0401 0.0617
Echinococcus multilocularis purine nucleoside phosphorylase 0.003 0.0072 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0103 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0167 0.1182
Echinococcus multilocularis methylthioadenosine phosphorylase 0.003 0.0072 0.0104
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.011 0.0791 0.0817
Mycobacterium ulcerans hydrolase/amidase 0.0561 0.4856 0.4846
Echinococcus granulosus methylthioadenosine phosphorylase 0.003 0.0072 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0631 0.091
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0727 0.6349 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0167 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0454 0.046
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.013 0.097 0.1494
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0021 0.0032
Echinococcus granulosus Protein patched homolog 1 0.0299 0.2496 0.3844
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0167 0.0257
Echinococcus multilocularis GPCR, family 2 0.0034 0.0103 0.0148
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0358 0.3025 0.4659
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0103 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0167 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0167 0.0155
Echinococcus multilocularis fatty acid amide hydrolase 1 0.01 0.0702 0.1012
Schistosoma mansoni patched 1 0.0299 0.2496 0.3844
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.028 0.0431
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0103 0.0148
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0757 0.0781
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.033 0.0475
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Loa Loa (eye worm) hypothetical protein 0.0073 0.0454 0.046
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0917 0.1413
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.013 0.097 0.1494
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.0477 0.0688
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0341 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0702 0.0723
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0757 0.0781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0167 0.0155
Schistosoma mansoni hypothetical protein 0.0688 0.5997 0.9234
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0167 0.0155
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0167 0.1182
Echinococcus multilocularis uridine phosphorylase 1 0.003 0.0072 0.0104
Echinococcus granulosus transcription factor Dp 1 0.0075 0.0477 0.0735
Schistosoma mansoni purine nucleoside phosphorylase 0.003 0.0072 0.0111
Loa Loa (eye worm) hypothetical protein 0.011 0.0791 0.0817
Chlamydia trachomatis AMP nucleosidase 0.003 0.0072 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0167 0.0241
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.0149
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0436 0.0671
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0167 0.0155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Schistosoma mansoni fatty-acid amide hydrolase 0.01 0.0702 0.1082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0087
Mycobacterium ulcerans short chain dehydrogenase 0.1133 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0167 0.0241
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0026 0.0037 0.0026
Schistosoma mansoni hypothetical protein 0.0688 0.5997 0.9234
Echinococcus granulosus tumor protein p63 0.0364 0.3078 0.4739
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0401 0.0617
Onchocerca volvulus 0.0041 0.0167 0.1182
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0358 0.3025 0.436
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0727 0.6349 1
Schistosoma mansoni bromodomain containing protein 0.0062 0.0361 0.0557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0167 0.0155
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0917 0.1322
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0167 0.0241
Echinococcus granulosus purine nucleoside phosphorylase 0.003 0.0072 0.0111
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.003 0.0072 0.0055
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0727 0.6349 0.9777
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.017 0.1335 0.4509
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0167 0.0155
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0167 0.0257
Echinococcus multilocularis microtubule associated protein 2 0.0743 0.6494 0.9358
Schistosoma mansoni hypothetical protein 0.0124 0.0917 0.1412
Brugia malayi ecdysteroid receptor 0.0041 0.0167 0.0155
Entamoeba histolytica hypothetical protein 0.0071 0.0436 0.2882
Echinococcus multilocularis 0.0024 0.0021 0.003
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0119 0.0875 0.2869
Loa Loa (eye worm) hypothetical protein 0.0119 0.0875 0.0906
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0757 0.0781
Echinococcus multilocularis purine nucleoside phosphorylase 0.003 0.0072 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0401 0.0617
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0329 0.0327
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0103 0.0158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.0106 0.0757 0.0781
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0299 0.2496 0.8657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0631 0.0972
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0341 0.2872 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.003 0.0072 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0917 0.0899
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.003 0.0072 0.0082
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0917 0.6825
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.013 0.097 0.1398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0917 0.0899
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0631 0.0648
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.003 0.0072 0.0052
Brugia malayi Cytochrome P450 family protein 0.0082 0.0537 0.0548
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0631 0.0972
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0358 0.3025 0.4659
Schistosoma mansoni methylthioadenosine phosphorylase 0.003 0.0072 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0167 0.0155
Leishmania major cytochrome p450-like protein 0.0059 0.0329 0.0488
Schistosoma mansoni uridine phosphorylase 0.003 0.0072 0.0111
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0119 0.0875 0.2869
Loa Loa (eye worm) cytochrome P450 family protein 0.0082 0.0537 0.0548
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0329 0.0309
Loa Loa (eye worm) hypothetical protein 0.1072 0.9453 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.097 0.15
Loa Loa (eye worm) hypothetical protein 0.0042 0.0178 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0329 0.0488
Echinococcus granulosus GPCR family 2 0.0034 0.0103 0.0158
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0119 0.0875 0.2869
Echinococcus multilocularis protein patched 0.0299 0.2496 0.3597
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.013 0.097 0.1007
Onchocerca volvulus 0.0119 0.0875 1
Schistosoma mansoni hypothetical protein 0.0034 0.0103 0.0158
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Mycobacterium ulcerans purine nucleoside phosphorylase 0.003 0.0072 0.0052
Entamoeba histolytica rodhanase-like domain containing protein 0.0119 0.0875 0.6363
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0167 0.0257
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.694 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0631 0.0648
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0341 0.2872 1
Brugia malayi PHD-finger family protein 0.0025 0.0021 0.0001
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.017 0.1335 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.003 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0109 0.0094
Onchocerca volvulus 0.0053 0.028 0.2584
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0917 0.1413
Brugia malayi hypothetical protein 0.0071 0.0436 0.044
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0103 0.0087
Brugia malayi Cytochrome P450 family protein 0.0059 0.0329 0.0327
Mycobacterium tuberculosis Hypothetical protein 0.003 0.0072 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.033 0.0508
Schistosoma mansoni cytochrome P450 0.0024 0.0021 0.0032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.097 0.15
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0299 0.2496 0.2625
Brugia malayi Bromodomain containing protein 0.0038 0.014 0.0126
Entamoeba histolytica hypothetical protein 0.0071 0.0436 0.2882
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.2496 0.3844
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0167 0.1182
Trichomonas vaginalis cdc25c, putative 0.0119 0.0875 0.2869
Schistosoma mansoni purine nucleoside phosphorylase 0.003 0.0072 0.0111
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0119 0.0875 0.2869
Trichomonas vaginalis cdc25b, putative 0.0119 0.0875 0.2869
Loa Loa (eye worm) RNA binding protein 0.0067 0.0401 0.0403
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0103 0.0158
Toxoplasma gondii Purine nucleoside phosphorylase 0.017 0.1335 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.003 0.0072 0.0104
Echinococcus multilocularis geminin 0.0688 0.5997 0.8642
Echinococcus granulosus microtubule associated protein 2 0.0743 0.6494 1
Brugia malayi nuclear hormone receptor 0.0041 0.0167 0.0155
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0329 0.0488
Brugia malayi uridine phosphorylase family protein 0.003 0.0072 0.0055
Treponema pallidum uridine phosphorylase (udp) 0.017 0.1335 1
Brugia malayi TAR-binding protein 0.0067 0.0401 0.0403
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.007 0.0427 0.0431
Entamoeba histolytica hypothetical protein 0.0071 0.0436 0.2882
Onchocerca volvulus 0.0119 0.0875 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0167 0.0241
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0727 0.6349 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0167 0.0155
Brugia malayi Cytochrome P450 family protein 0.0059 0.0329 0.0327
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0119 0.0875 0.1348
Trypanosoma brucei uridine phosphorylase 0.003 0.0072 0.0082
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0329 0.0327
Echinococcus multilocularis purine nucleoside phosphorylase 0.003 0.0072 0.0104
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0358 0.3025 0.3186
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.017 0.1335 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0167 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0167 0.0155
Schistosoma mansoni hypothetical protein 0.0034 0.0103 0.0158
Echinococcus multilocularis sterol regulatory element binding protein 0.0299 0.2496 0.3597
Schistosoma mansoni amidase 0.01 0.0702 0.1082
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0917 0.0899
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0401 0.0403
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0167 0.0241
Echinococcus multilocularis thyroid hormone receptor alpha 0.0165 0.1284 0.185
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0917 0.1417
Loa Loa (eye worm) hypothetical protein 0.0727 0.6349 0.6709
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0167 0.0155

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.03 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID465] ChEMBL. No reference
IC50 (functional) = 75.6 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID489026] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: SAR analysis of small molecule cytotoxicity in HEK293 cells for activators of NF-kappaB using a luminescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID435022, AID435025] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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