Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.02 | 0.6029 | 0.5109 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1881 | 0.3013 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.6242 | 0.5371 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0301 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0147 | 0.3906 | 0.3719 |
Loa Loa (eye worm) | TAR-binding protein | 0.02 | 0.6029 | 0.5109 |
Onchocerca volvulus | 0.0168 | 0.4762 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.02 | 0.6029 | 0.7616 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0147 | 0.3906 | 0.6258 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.6029 | 0.9658 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.7327 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0095 | 0.1881 | 0.1881 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0206 | 0.6242 | 0.6242 |
Brugia malayi | hypothetical protein | 0.0233 | 0.7327 | 0.7327 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.7327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 0.6242 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1881 | 0.3013 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.6029 | 0.9658 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.7327 | 0.6708 |
Echinococcus multilocularis | tar DNA binding protein | 0.02 | 0.6029 | 0.7616 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0147 | 0.3906 | 0.3906 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0147 | 0.3906 | 0.2495 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1881 | 0.3013 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0168 | 0.4762 | 0.3549 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.6029 | 0.9658 |
Brugia malayi | TAR-binding protein | 0.02 | 0.6029 | 0.6029 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0168 | 0.4762 | 0.4762 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1881 | 0.3013 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.6029 | 0.9658 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.02 | 0.6029 | 0.5109 |
Onchocerca volvulus | 0.0168 | 0.4762 | 1 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0147 | 0.3906 | 0.3719 |
Brugia malayi | RNA recognition motif domain containing protein | 0.02 | 0.6029 | 0.6029 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0095 | 0.1881 | 0.1881 |
Brugia malayi | RNA binding protein | 0.02 | 0.6029 | 0.6029 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.6029 | 0.9658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.