Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3285 | 0.3273 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0164 | 0.0499 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0164 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0054 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3285 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3285 | 0.3273 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0179 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3285 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0164 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3285 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3285 | 1 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3285 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0164 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0164 | 0.0499 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3285 | 0.3273 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0006 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0164 | 0.0146 |
Onchocerca volvulus | 0.0009 | 0.0164 | 0.0146 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3285 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3285 | 0.3273 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0164 | 0.0499 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor | 0.0006 | 0.0018 | 0.0054 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3285 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3285 | 0.3273 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0164 | 0.0499 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0054 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 1 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3285 | 0.3273 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.