Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.192 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0058 | 0.192 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0333 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.192 | 0.6472 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.192 | 0.6472 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0058 | 0.192 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0333 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.192 | 0.6472 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.1741 | 0.1456 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0333 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2784 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0333 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2784 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2784 | 0.2536 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0333 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2784 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2784 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2784 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0333 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2784 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2784 | 0.2536 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 0.5 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.192 | 0.1641 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2784 | 0.2536 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2784 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0333 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2784 | 0.2536 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0333 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0333 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.192 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0333 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0333 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2784 | 0.2536 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2784 | 0.2536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.