Detailed information for compound 1540070

Basic information

Technical information
  • TDR Targets ID: 1540070
  • Name: STK275167
  • MW: 414.453 | Formula: C25H22N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)c1ccccc1N1C(=O)C2C(C1=O)C1C=CC2C2C1C2
  • InChi: 1S/C25H22N2O4/c1-31-14-6-4-5-13(11-14)26-23(28)17-7-2-3-8-20(17)27-24(29)21-15-9-10-16(19-12-18(15)19)22(21)25(27)30/h2-11,15-16,18-19,21-22H,12H2,1H3,(H,26,28)
  • InChiKey: YUIOLTJERQAJEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AK-918/40893560

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.002 0.0148 0.0325
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0088 0.0173
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.1042 0.0924
Brugia malayi beta-lactamase family protein 0.0042 0.1042 0.2547
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1042 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 1
Plasmodium vivax vivapain-2 0.0018 0.0088 0.0141
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 0.5
Onchocerca volvulus Terribly reduced optic lobes homolog 0.002 0.0148 0.015
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0148 0.0362
Loa Loa (eye worm) hypothetical protein 0.012 0.4091 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1042 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0053 0.013
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.2542 0.8506
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0053 0.013
Onchocerca volvulus Basement membrane proteoglycan homolog 0.002 0.0148 0.015
Onchocerca volvulus 0.0042 0.1042 0.2383
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.1042 0.2547
Leishmania major hypothetical protein, conserved 0.0018 0.0078 0.0122
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.1042 0.2547
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0173
Brugia malayi beta-lactamase 0.0042 0.1042 0.2547
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0469 0.1672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0088 0.012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.013 0.0378
Brugia malayi basement membrane proteoglycan precursor 0.002 0.0148 0.0362
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0321 0.0786
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.013 0.0378
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.2542 1
Onchocerca volvulus 0.002 0.0148 0.015
Brugia malayi beta-lactamase family protein 0.0042 0.1042 0.2547
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1987 0.661
Trypanosoma cruzi ISWI complex protein 0.0018 0.0078 0.0122
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.1905 0.633
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.102 0.3303
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.002 0.0148 0.0362
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0088 0.012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.1314
Mycobacterium tuberculosis Conserved protein 0.0042 0.1042 0.0924
Loa Loa (eye worm) cysteine protease 0.0018 0.0088 0.0216
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1586 0.5238
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.014 0.0298
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1987 0.661
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1586 0.3876
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0088 0.012
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1042 0.488
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.1042 0.0924
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.1042 0.0924
Schistosoma mansoni bromodomain containing protein 0.0073 0.2268 0.7569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Echinococcus granulosus low density lipoprotein receptor protein 0.002 0.0148 0.0325
Echinococcus granulosus basement membrane specific heparan sulfate 0.002 0.0148 0.0325
Loa Loa (eye worm) hypothetical protein 0.0042 0.1042 0.2547
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1586 0.5238
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0216
Mycobacterium ulcerans hypothetical protein 0.0042 0.1042 0.3781
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0538 0.1314
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.1992 0.4871
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0409 0.1215
Loa Loa (eye worm) hypothetical protein 0.012 0.4091 1
Toxoplasma gondii hypothetical protein 0.0028 0.0469 0.1672
Leishmania major hypothetical protein, conserved 0.0042 0.1042 0.488
Brugia malayi jmjC domain containing protein 0.0017 0.0053 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0173
Echinococcus multilocularis musashi 0.0029 0.0538 0.1656
Schistosoma mansoni hypothetical protein 0.0024 0.0321 0.0917
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0409 0.1215
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0088 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2979 1
Echinococcus multilocularis cysteine protease 0.0018 0.0088 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Onchocerca volvulus 0.002 0.0148 0.015
Toxoplasma gondii ABC1 family protein 0.0042 0.1042 0.3973
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.2979 0.7282
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Brugia malayi jmjC domain containing protein 0.0064 0.1905 0.4657
Echinococcus multilocularis low density lipoprotein receptor protein 0.002 0.0148 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.2542 0.8506
Schistosoma mansoni lamin 0.0029 0.0538 0.1656
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1586 0.6035
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Brugia malayi intermediate filament protein 0.0029 0.0538 0.1314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2979 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.013 0.0308
Entamoeba histolytica hypothetical protein 0.0035 0.0776 1
Onchocerca volvulus 0.0029 0.0538 0.1123
Mycobacterium tuberculosis Conserved protein 0.0042 0.1042 0.0924
Brugia malayi Bromodomain containing protein 0.0044 0.1128 0.2757
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1042 0.3379
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0088 0.0141
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0173
Echinococcus multilocularis lamin 0.0029 0.0538 0.1656
Brugia malayi enteropeptidase precursor 0.002 0.0148 0.0362
Brugia malayi jmjC domain containing protein 0.0066 0.1992 0.4871
Brugia malayi jmjC domain containing protein 0.0017 0.0053 0.013
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0469 0.1672
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0409 0.1215
Entamoeba histolytica hypothetical protein 0.0035 0.0776 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1586 0.6035
Brugia malayi hypothetical protein 0.0035 0.0776 0.1896
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.1453 0.134
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.1042 0.3781
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.002 0.0148 0.0362
Mycobacterium tuberculosis Conserved protein 0.0042 0.1042 0.0924
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.208 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0088 0.0141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.1042 0.2547
Echinococcus granulosus basement membrane specific heparan sulfate 0.002 0.0148 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Onchocerca volvulus Huntingtin homolog 0.012 0.4091 1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.002 0.0148 0.0325
Echinococcus granulosus cathepsin l1 0.0018 0.0088 0.012
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.1437 0.3513
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.002 0.0148 0.0325
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.1453 0.4783
Schistosoma mansoni ap endonuclease 0.0019 0.013 0.0262
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.013 0.0317
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.1042 0.3379
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1987 0.777
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.2105 0.7011
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.014 0.0298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.013
Loa Loa (eye worm) hypothetical protein 0.008 0.2542 0.6214
Loa Loa (eye worm) beta-lactamase 0.0042 0.1042 0.2547
Trypanosoma cruzi ISWI complex protein 0.0018 0.0078 0.0122
Brugia malayi jmjC domain containing protein 0.0017 0.0053 0.013
Leishmania major cathepsin L-like protease 0.0069 0.208 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.208 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.002 0.0148 0.0325
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1042 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.013 0.0378
Echinococcus multilocularis basement membrane specific heparan sulfate 0.002 0.0148 0.0325
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0538 0.1314
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.013 0.0435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1987 0.77
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2979 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.1845 0.8844
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1502 0.7148
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0186 0.0455
Echinococcus granulosus intermediate filament protein 0.0029 0.0538 0.1656
Loa Loa (eye worm) hypothetical protein 0.002 0.0158 0.0386
Entamoeba histolytica hypothetical protein 0.0035 0.0776 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0088 0.0216
Schistosoma mansoni intermediate filament proteins 0.0029 0.0538 0.1656
Schistosoma mansoni ap endonuclease 0.0019 0.013 0.0262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.1992 0.6628
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2979 1
Brugia malayi Probable ClpP-like protease 0.008 0.2542 0.6214
Echinococcus multilocularis basement membrane specific heparan sulfate 0.002 0.0148 0.0325
Echinococcus multilocularis lamin dm0 0.0029 0.0538 0.1656
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.013 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.1239 0.3029
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0776 0.247
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Echinococcus granulosus zinc finger protein 0.0023 0.0273 0.0752
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.1042 0.0924
Brugia malayi Bromodomain containing protein 0.0087 0.2803 0.6851
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.1042 0.488
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.013 0.0262
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0088 0.012
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0216
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0158 0.0358
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.208 1
Schistosoma mansoni zinc finger protein 0.0023 0.0273 0.0752
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0538 0.1314
Onchocerca volvulus 0.0042 0.1042 0.2383
Schistosoma mansoni hypothetical protein 0.0018 0.0078 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0158 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.002 0.0148 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1042 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1042 0.2547
Toxoplasma gondii cathepsin CPL 0.0018 0.0088 0.0141
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.1453 0.4783
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.1905 0.633
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0088 0.012
Schistosoma mansoni hypothetical protein 0.002 0.0148 0.0325
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.1042 0.0924
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0088 0.0173
Mycobacterium leprae Probable lipase LipE 0.0042 0.1042 0.2763
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.102 0.3303
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.002 0.0148 0.0325
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1987 0.1882
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0088 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0158 0.0358
Onchocerca volvulus 0.002 0.0148 0.015
Entamoeba histolytica hypothetical protein 0.0035 0.0776 1
Trichomonas vaginalis esterase, putative 0.0042 0.1042 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.013 0.0262
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1987 0.661
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.1042 0.0924
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0776 0.247
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2979 1
Onchocerca volvulus 0.0029 0.0538 0.1123
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Leishmania major cathepsin L-like protease 0.0069 0.208 1
Onchocerca volvulus Huntingtin homolog 0.012 0.4091 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Loa Loa (eye worm) fibroinase 0.0018 0.0088 0.0216
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.002 0.0148 0.0362
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.1992 0.6628
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1042 0.3379
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.002 0.0148 0.0362
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0088 0.012
Echinococcus granulosus lamin 0.0029 0.0538 0.1656
Schistosoma mansoni jumonji domain containing protein 0.0064 0.1905 0.633
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.208 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0216
Brugia malayi PHD-finger family protein 0.0029 0.0517 0.1263
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0216
Loa Loa (eye worm) hypothetical protein 0.0082 0.2608 0.6374
Schistosoma mansoni hypothetical protein 0.0035 0.0776 0.247
Loa Loa (eye worm) ctsf protein 0.0018 0.0088 0.0216
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.1453 0.134
Brugia malayi CUB domain containing protein 0.002 0.0148 0.0362
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1987 0.77
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.2542 1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.002 0.0148 0.0325
Brugia malayi jmjC domain containing protein 0.0017 0.0053 0.013
Schistosoma mansoni hypothetical protein 0.002 0.0148 0.0325
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.1042 0.0924
Onchocerca volvulus Arrow homolog 0.002 0.0148 0.015
Onchocerca volvulus 0.002 0.0148 0.015
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.2542 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Schistosoma mansoni lamin 0.0029 0.0538 0.1656
Toxoplasma gondii exonuclease III APE 0.0019 0.013 0.0308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.013 0.0378
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.1042 0.3379
Echinococcus granulosus low density lipoprotein receptor ldl 0.002 0.0148 0.0325
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0216
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.1453 0.4744
Loa Loa (eye worm) hypothetical protein 0.0042 0.1042 0.2547
Mycobacterium ulcerans beta-lactamase 0.0042 0.1042 0.3781
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.002 0.0148 0.0325
Mycobacterium leprae conserved hypothetical protein 0.0042 0.1042 0.2763
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0158 0.0358
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.1042 0.3781
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0469 0.1407
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1987 0.661
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1042 0.488
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.1586 0.7563
Trypanosoma brucei ISWI complex protein 0.0018 0.0078 0.0122
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.013 0.0603
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.013 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2979 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.1586 0.5238
Mycobacterium ulcerans lipase LipD 0.0042 0.1042 0.3781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.208 1
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.002 0.0148 0.0325
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1987 0.9544
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0158 0.0358
Schistosoma mansoni zinc finger protein 0.0018 0.0078 0.0085
Echinococcus multilocularis zinc finger protein 0.0023 0.0273 0.0752
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0173
Onchocerca volvulus 0.002 0.0148 0.015
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0088 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.1042 0.2547
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.2979 0.7282
Loa Loa (eye worm) hypothetical protein 0.0044 0.1131 0.2765
Loa Loa (eye worm) hypothetical protein 0.0029 0.0517 0.1263
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0776 0.247
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0088 0.012
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0148 0.0325
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.013 0.0317
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.013 0.0308
Echinococcus granulosus lamin dm0 0.0029 0.0538 0.1656
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0158 0.0358
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0088 0.012
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0158 0.0358
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.2542 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.2105 0.7011
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0053 0.013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.1905 0.633
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0216
Echinococcus multilocularis cysteine protease 0.0018 0.0088 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1042 1
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0173
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.2542 0.8506
Loa Loa (eye worm) hypothetical protein 0.0042 0.1042 0.2547
Onchocerca volvulus 0.0042 0.1042 0.2383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2979 1
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.002 0.0148 0.0362
Brugia malayi hypothetical protein 0.012 0.4091 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1987 0.77
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.002 0.0148 0.0325
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0362
Loa Loa (eye worm) hypothetical protein 0.0049 0.1326 0.3242
Echinococcus granulosus low density lipoprotein receptor ldl 0.002 0.0148 0.0325
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.2542 1
Plasmodium vivax vivapain-2 0.0018 0.0088 0.0141
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.1586 0.1475
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.1992 0.6628
Leishmania major cathepsin L-like protease 0.0069 0.208 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0158 0.0358
Plasmodium vivax hypothetical protein, conserved 0.0042 0.1042 0.3973
Onchocerca volvulus 0.002 0.0148 0.015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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