Detailed information for compound 1540169

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.783 | Formula: C17H16ClF3N4O2
  • H donors: 0 H acceptors: 2 LogP: 3.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1OC(F)(F)F)Cn1cnc2c(c1=O)cnn2C(C)(C)C
  • InChi: 1S/C17H16ClF3N4O2/c1-16(2,3)25-14-11(7-23-25)15(26)24(9-22-14)8-10-4-5-12(18)13(6-10)27-17(19,20)21/h4-7,9H,8H2,1-3H3
  • InChiKey: GOFZNOLVGAYGOB-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0251
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0053 0.0549
Echinococcus multilocularis dna polymerase kappa 0.002 0.0053 0.0043
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0028 0.0283
Brugia malayi follicle stimulating hormone receptor 0.0227 0.1342 0.1723
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0045 0.0153
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0189 0.1399
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0229 0.1356 0.2155
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0045 0.0437
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.035 0.05
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.0723 0.7446
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0036 0.0157 0.0228
Loa Loa (eye worm) hypothetical protein 0.0102 0.0567 0.0822
Onchocerca volvulus 0.0057 0.0288 0.0297
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0139 0.0969
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0168 0.0972 0.1523
Leishmania major cathepsin L-like protease 0.0128 0.0723 0.6039
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0045 0.0437
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.035 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0037 0.0026
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0189 0.0235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.021 0.02
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0379 0.2287 0.3687
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0193 0.0183
Plasmodium vivax vivapain-2 0.0033 0.0139 0.1433
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0723 0.7446
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0078
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0042 0.006
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0189 0.1579
Loa Loa (eye worm) acetyltransferase 0.0155 0.0893 0.1295
Schistosoma mansoni single-minded 0.0015 0.0028 0.0055
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0337 0.2026 0.4672
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0136 0.14
Brugia malayi isocitrate dehydrogenase 0.0033 0.0136 0.0175
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0401 0.039
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0667 0.4076 0.6639
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0168 0.0972 1
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0723 0.7446
Entamoeba histolytica hypothetical protein 0.0025 0.0088 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0193 0.0385
Mycobacterium ulcerans thioesterase TesA 0.0556 0.3385 0.5492
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0168 0.0972 1
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0189 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0131
Brugia malayi Methyltransferase-like protein 4 0.0201 0.118 0.1515
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0028 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Echinococcus granulosus Smad4 0.0017 0.0037 0.0052
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.3092
Toxoplasma gondii exonuclease III APE 0.0018 0.0046 0.0099
Brugia malayi Cathepsin L-like precursor 0.0022 0.007 0.009
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.021 0.1233 0.1977
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0189 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.0193 0.0439
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0168 0.0972 0.1939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0136 0.0175
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0088 0.0154
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.035 0.0529
Loa Loa (eye worm) hypothetical protein 0.1121 0.6894 1
Echinococcus multilocularis cysteine protease 0.0033 0.0139 0.0129
Leishmania major cathepsin L-like protease 0.0033 0.0139 0.0969
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0139 0.0094
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.0193 0.1985
Echinococcus multilocularis Smad4 0.0017 0.0037 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.021 0.0304
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.03
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0102 0.0567 0.0857
Loa Loa (eye worm) hypothetical protein 0.0052 0.0252 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Brugia malayi hypothetical protein 0.0036 0.0157 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0131
Leishmania major cathepsin L-like protease 0.0033 0.0139 0.0969
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0053 0.0043
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.3092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0095 0.0139
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0139 0.0257
Brugia malayi MH2 domain containing protein 0.0017 0.0037 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.035 0.05
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0214 0.2203
Schistosoma mansoni ap endonuclease 0.0018 0.0046 0.0091
Schistosoma mansoni lamin 0.0026 0.0095 0.0191
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0045 0.0065
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0029 0.0058
Brugia malayi Cathepsin L-like precursor 0.0033 0.0139 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0037 0.0053
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.035 0.05
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0189 0.1942
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.035 0.05
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.0893 0.1782
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0139 0.0257
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0053 0.0429
Onchocerca volvulus 0.0033 0.0139 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.013 0.0293
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0401 0.0514
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.015 0.014
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.035 0.034
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.0193 0.1985
Mycobacterium ulcerans polyketide synthase Pks9 0.0441 0.2672 0.4319
Onchocerca volvulus 0.0041 0.0189 0.0161
Chlamydia trachomatis acyl carrier protein 0.0067 0.035 0.3415
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.0226
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.007 0.009
Brugia malayi hypothetical protein 0.0035 0.015 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0045 0.0437
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0038 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0028 0.021
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0168 0.0972 0.1922
Schistosoma mansoni acyl carrier protein 0.0067 0.035 0.0698
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0028 0.0283
Mycobacterium leprae Probable polyketide synthase Pks1 0.0709 0.4333 0.7061
Toxoplasma gondii type I fatty acid synthase, putative 0.0709 0.4333 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.013 0.2527
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0102 0.0567 0.0885
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0189 0.1919
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0189 0.0235
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0537 0.3266 0.5297
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0168 0.0972 0.1409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0189 0.0235
Leishmania major oxidoreductase, putative 0.0041 0.0189 0.1399
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0189 0.0377
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0441 0.2672 0.4337
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.035 0.05
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0136 0.0148
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0139 0.2783
Loa Loa (eye worm) hypothetical protein 0.0189 0.1103 0.16
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0045 0.0437
Plasmodium vivax vivapain-1 0.0017 0.0038 0.0395
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0026 0.0038
Echinococcus multilocularis GPCR, family 2 0.0015 0.0026 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0053 0.0107
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0136 0.0942
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0028 0.021
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0038 0.0395
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.0193 0.1589
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0028 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Mycobacterium ulcerans polyketide synthase 0.0667 0.4076 0.6629
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0401 0.4123
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0189 0.0274
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0189 0.1919
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0088 0.0903
Loa Loa (eye worm) ctsf protein 0.0033 0.0139 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0667 0.4076 0.6629
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.0655 0.6739
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0537 0.3266 0.5311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0053 0.0549
Echinococcus granulosus AMP dependent ligase 0.0067 0.035 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Mycobacterium ulcerans acyl carrier protein 0.0067 0.035 0.05
Brugia malayi Cathepsin L-like precursor 0.0033 0.0139 0.0179
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.035 0.0449
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0139 0.108
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.013 0.1337
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0205 0.1205 0.1907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0624 0.3803 0.5517
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0709 0.4333 0.7052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.035 0.86
Echinococcus granulosus lamin 0.0026 0.0095 0.017
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0168 0.0972 0.1523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Entamoeba histolytica cysteine protease, putative 0.0033 0.0139 0.2783
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0095 0.0123
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0045 0.0187
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0189 0.1942
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0038 0.0077
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0053 0.0224
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0038
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.0893 0.1146
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.002 0.0019
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0189 0.0235
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0168 0.0972 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0095 0.0139
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0189 0.0429
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0078
Leishmania major cathepsin L-like protease 0.0128 0.0723 0.6039
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0139 0.0278
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0189 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0038 0.0367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.035 0.05
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0549 0.547
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0168 0.0972 0.2237
Echinococcus granulosus cathepsin l1 0.0033 0.0139 0.0257
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0037 0.0073
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0139 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0139 0.1158
Echinococcus granulosus cpg binding protein 0.0061 0.0308 0.0595
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0139 0.0129
Schistosoma mansoni hypothetical protein 0.0531 0.3227 0.6441
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0139 0.0094
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0088 0.0876
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.004 0.0052
Mycobacterium ulcerans Type I modular polyketide synthase 0.0667 0.4076 0.6629
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0052
Echinococcus multilocularis cpg binding protein 0.0061 0.0308 0.0298
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0134
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0401 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.007 0.0141
Echinococcus multilocularis dnaJ subfamily B 0.0818 0.501 0.5005
Giardia lamblia DINP protein human, muc B family 0.002 0.0053 0.0072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0126
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0667 0.4076 0.6639
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0139 0.0179
Schistosoma mansoni lamin 0.0026 0.0095 0.0191
Leishmania major hypothetical protein, conserved 0.0201 0.118 1
Trypanosoma brucei unspecified product 0.002 0.0053 0.0522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0667 0.4076 0.6629
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0028 0.0283
Loa Loa (eye worm) hypothetical protein 0.0048 0.023 0.0334
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0045 0.0058
Loa Loa (eye worm) hypothetical protein 0.0076 0.0401 0.0581
Toxoplasma gondii cathepsin CPL 0.0033 0.0139 0.0315
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.002 0.0009
Trypanosoma brucei acyl transferase-like protein 0.0042 0.0193 0.1962
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0193 0.0385
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.007 0.0886
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0046 0.0059
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0038 0.0395
Echinococcus granulosus NADH dehydrogenase 0.0067 0.035 0.0679
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.023 0.0334
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0189 0.0235
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.1342 0.1946
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0026 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0045 0.0058
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0554 0.5701
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0998 0.6125 1
Onchocerca volvulus 0.0033 0.0139 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Echinococcus granulosus cysteine protease 0.0017 0.0038 0.0056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0026 0.0033
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0271
Schistosoma mansoni smad1 5 8 and 0.0017 0.0037 0.0073
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.0893 0.0883
Echinococcus granulosus lamin dm0 0.0026 0.0095 0.017
Schistosoma mansoni cpg binding protein 0.0061 0.0308 0.0615
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0709 0.4333 0.7052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0046 0.0066
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0037 0.0052
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0052
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0037 0.0053
Toxoplasma gondii type I fatty acid synthase, putative 0.0475 0.2881 0.6648
Treponema pallidum acyl carrier protein 0.0067 0.035 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0667 0.4076 0.5234
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0139 0.0202
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0102 0.0567 0.0857
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0046 0.0444
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0046 0.0035
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0046 0.0006
Loa Loa (eye worm) acyl carrier protein 0.0307 0.1837 0.2665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0045 0.0153
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.035 0.0529
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0168 0.0972 0.0962
Brugia malayi Cathepsin L-like precursor 0.0033 0.0139 0.0179
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0045 0.0465
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0052
Echinococcus granulosus expressed protein 0.0033 0.0135 0.0248
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0709 0.4333 0.7061
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0045 0.0465
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0139 0.0129
Brugia malayi intermediate filament protein 0.0026 0.0095 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.021 0.0419
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0028 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0088 0.0721
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0053 0.0522
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0189 0.0178
Schistosoma mansoni hypothetical protein 0.0067 0.035 0.0698
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.0226
Mycobacterium ulcerans polyketide synthase Pks13 0.0998 0.6125 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0102
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0139 0.0094
Echinococcus granulosus dnaJ subfamily B 0.0818 0.501 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0135 0.112
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.035 0.3583
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.0193 0.1656
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0036 0.0157 0.0202
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0189 0.0377
Mycobacterium ulcerans Type I modular polyketide synthase 0.0667 0.4076 0.6629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0197
Echinococcus granulosus GPCR family 2 0.0015 0.0026 0.0031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0066 0.0677
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0189 0.0235
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0401 0.078
Schistosoma mansoni hypothetical protein 0.0818 0.501 1
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0036 0.0157 0.0314
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0088 0.0196
Echinococcus granulosus geminin 0.0531 0.3227 0.6434
Schistosoma mansoni DNA polymerase eta 0.002 0.0053 0.0107
Loa Loa (eye worm) fatty acid synthase 0.0659 0.4021 0.5832
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0189 0.1942
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0046 0.0471
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0038 0.0077
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0139 0.108
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0053 0.0549
Brugia malayi MH2 domain containing protein 0.0017 0.0037 0.0047
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0189 0.1942
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0189 0.0235
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0136 0.14
Schistosoma mansoni smad1 5 8 and 0.0017 0.0037 0.0073
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0045 0.0035
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1265 0.7787 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Mycobacterium ulcerans polyketide synthase MbtD 0.0205 0.1205 0.1907
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0037 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.021 0.0399
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.019 0.1281
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0136 0.0308
Brugia malayi CXXC zinc finger family protein 0.0057 0.0288 0.037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0046 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0053 0.0522
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0189 0.0235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Mycobacterium ulcerans oxidoreductase 0.0041 0.0189 0.0235
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0052 0.0253 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.035 0.05
Brugia malayi MH1 domain containing protein 0.0017 0.0037 0.0047
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0045 0.0187
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0045 0.0465
Leishmania major cathepsin L-like protease 0.0033 0.0139 0.0969
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.3092
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0155 0.02
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.035 0.05
Onchocerca volvulus 0.0033 0.0139 0.0094
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.002 0.0019
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0193 0.0365
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0045 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0302
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.035 0.0449
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0102 0.0567 0.0857
Loa Loa (eye worm) hypothetical protein 0.0041 0.0189 0.0274
Mycobacterium ulcerans fatty acid synthase Fas 0.021 0.1233 0.1953
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0053 0.0086
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.035 0.05
Loa Loa (eye worm) acyl carrier protein 0.0067 0.035 0.0508
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.035 0.05
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0053 0.0522
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.0193 0.0248
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0189 0.0235
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0136 0.0126
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0214 0.0407
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.035 0.0679
Brugia malayi AMP-binding enzyme family protein 0.0205 0.1205 0.1548
Echinococcus multilocularis lamin dm0 0.0026 0.0095 0.0085
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.063 0.1449
Mycobacterium ulcerans acyl carrier protein 0.0067 0.035 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Trypanosoma brucei unspecified product 0.0014 0.0015 0.0131
Mycobacterium ulcerans polyketide synthase 0.0709 0.4333 0.7052
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0537 0.3266 0.5297
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0053 0.0012
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0189 0.415
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0045 0.0098
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0028 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Leishmania major protein kinase, putative 0.002 0.0053 0.0219
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0045 0.0465
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0401 0.3238
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0042 0.0031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0045 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0131
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0401 0.039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0046 0.008
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0189 0.0235
Schistosoma mansoni rotamase 0.0033 0.0135 0.0269
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0136 0.1375
Mycobacterium ulcerans polyketide synthase MbtC 0.0168 0.0972 0.1523
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.1479 0.2145
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.035 0.05
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0866 0.1711
Onchocerca volvulus 0.0041 0.0189 0.0161
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0189 0.1579
Leishmania major quinone oxidoreductase, putative 0.0041 0.0189 0.1399
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0214 0.1794
Mycobacterium tuberculosis Conserved protein 0.0201 0.118 0.1865
Echinococcus granulosus smad 0.0017 0.0037 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0102
Onchocerca volvulus Protein cycle homolog 0.0036 0.0157 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.0226
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0401 0.3379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0136 0.0174
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.013 0.0888
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.021 0.0419
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0189 0.1942
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0028 0.0283
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0189 0.0235
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0189 0.1942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.021 0.0419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0053 0.0522
Schistosoma mansoni methyltransferase-related 0.0201 0.118 0.2355
Echinococcus granulosus aryl hydrocarbon receptor 0.0052 0.0253 0.0486
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0038 0.0049
Onchocerca volvulus 0.1162 0.7145 0.9649
Loa Loa (eye worm) cysteine protease 0.0033 0.0139 0.0202
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0189 0.0235
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.028
Brugia malayi MH2 domain containing protein 0.0249 0.1479 0.1899
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0546 0.3321 0.5386
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.023 0.0296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0078
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0189 0.0235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0624 0.3803 0.4885
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.4134 0.4128
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0189 0.0235
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0046 0.0205
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0139 0.0278
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0667 0.4076 0.6629
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.035 0.0381
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0045 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0045 0.0153
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0624 0.3803 0.6181
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0028 0.021
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0135 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0549 0.5649
Onchocerca volvulus 0.0624 0.3803 0.5092
Leishmania major DNA polymerase kappa, putative 0.002 0.0053 0.0224
Plasmodium vivax vivapain-2 0.0033 0.0139 0.1433
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0136 0.14
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0139 0.0202
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.035 0.05
Brugia malayi hypothetical protein 0.0052 0.0252 0.0323
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0189 0.0235
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0015
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0189 0.1919
Schistosoma mansoni intermediate filament proteins 0.0026 0.0095 0.0191
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0136 0.0126
Trypanosoma brucei unspecified product 0.0014 0.0015 0.0131
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0139 0.0129
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0189 0.1399
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0401 0.4123
Giardia lamblia Methyltransferase like 2 0.0201 0.118 1
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0028 0.021
Echinococcus granulosus dna polymerase eta 0.002 0.0053 0.0086
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0189 0.0356
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0053 0.0414
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0401 0.3133
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0139 0.1158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0688 0.1373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.013 0.1337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0102 0.0567 0.0857
Mycobacterium ulcerans hypothetical protein 0.0067 0.035 0.05
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0041 0.0189 0.0264
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0401 0.08
Schistosoma mansoni hypothetical protein 0.0531 0.3227 0.6441
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.035 0.3285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0046 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.035 0.05
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0088 0.0113
Echinococcus multilocularis expressed protein 0.0033 0.0135 0.0124
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0189 0.0242
Plasmodium falciparum acyl carrier protein 0.0067 0.035 0.3338
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.015 0.028
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0042 0.0062
Mycobacterium leprae Polyketide synthase Pks13 0.0998 0.6125 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0045 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0647 0.3949 0.642
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.1479 0.2145
Echinococcus multilocularis lamin 0.0026 0.0095 0.0085
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0189 0.1942
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0041 0.0189 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0723 0.7446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0189 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Schistosoma mansoni smad1 5 8 and 0.0017 0.0037 0.0073
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0046 0.0471
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0139 0.1433
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0168 0.0972 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0088 0.0175
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0028 0.021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.023 0.0296
Loa Loa (eye worm) Smad1 0.0017 0.0037 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0302
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0189 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Echinococcus multilocularis AMP dependent ligase 0.0067 0.035 0.034
Loa Loa (eye worm) hypothetical protein 0.0102 0.0567 0.0822
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0709 0.4333 0.7052
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.035 0.05
Echinococcus granulosus cathepsin l1 0.0022 0.007 0.012
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.035 0.034
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0168 0.0972 1
Plasmodium vivax acyl carrier protein, putative 0.0067 0.035 0.3601
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Echinococcus granulosus microtubule associated protein 2 0.0677 0.4134 0.8247
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0189 0.0235
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0046 0.0159
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0038 0.0395
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.035 0.3601
Brugia malayi Smad1 0.0017 0.0037 0.0047
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0433 0.262 0.6043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0012 0.0078
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0189 0.0242
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.019 0.163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.021 0.02
Leishmania major cathepsin L-like protease 0.0033 0.0139 0.0969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Onchocerca volvulus 0.0071 0.0373 0.0413
Toxoplasma gondii type I fatty acid synthase 0.0102 0.0567 0.1303
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0053 0.0077
Trichomonas vaginalis rotamase, putative 0.0032 0.013 0.108
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0135 0.0195
Loa Loa (eye worm) fibroinase 0.0033 0.0139 0.0202
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0189 0.1942
Echinococcus multilocularis dna polymerase eta 0.002 0.0053 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0136 0.0197
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0214 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.035 0.0449
Echinococcus multilocularis smad 0.0017 0.0037 0.0026
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.013 0.1312
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0189 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.0193 0.1985
Echinococcus multilocularis geminin 0.0531 0.3227 0.322
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0028 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0401 0.3379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.3092
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0189 0.0242
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0189 0.0242
Leishmania major acyl carrier protein, putative 0.0067 0.035 0.2798
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0036 0.0157 0.0202
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0189 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.002 0.004
Trichomonas vaginalis rotamase, putative 0.0033 0.0135 0.112
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0038 0.0395
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Brugia malayi Cathepsin L-like precursor 0.0033 0.0139 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0189 0.0235
Onchocerca volvulus 0.0026 0.0095 0.0034
Echinococcus granulosus cathepsin L 0.0017 0.0038 0.0056
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0401 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.035 0.0801
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.021 0.0269
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0193 0.0385
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.021 0.1233 0.1953
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0139 0.108
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0163 0.0944 0.1477
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.002 0.0009
Leishmania major cathepsin L-like protease 0.0128 0.0723 0.6039
Leishmania major d-xylulose reductase, putative 0.0041 0.0189 0.1399
Echinococcus multilocularis cysteine protease 0.0033 0.0139 0.0129
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0045 0.0035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0053 0.0549
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0088 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0139 0.2783
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0028 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0095 0.0139
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0401 0.08
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0168 0.0972 0.8193
Trichomonas vaginalis helicase, putative 0.0013 0.0012 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0053 0.0012
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0709 0.4333 0.7061
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.118 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.027 0.1607 0.2568
Echinococcus multilocularis musashi 0.0026 0.0095 0.0085
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.035 0.0508
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0168 0.0972 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0401 0.3379
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0401 0.4106
Echinococcus granulosus dna polymerase kappa 0.002 0.0053 0.0086
Brugia malayi MH1 domain containing protein 0.0017 0.0037 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0026 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0067 0.035 0.0529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0046 0.0471
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0709 0.4333 0.7052
Echinococcus multilocularis aryl hydrocarbon receptor 0.0052 0.0253 0.0243
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0045 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Onchocerca volvulus Fatty acid synthase homolog 0.1203 0.7402 1
Onchocerca volvulus 0.0033 0.0139 0.0094
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.1103 0.1408
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0189 0.0429
Plasmodium vivax vivapain-3 0.0017 0.0038 0.0395
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0029 0.0019
Brugia malayi cathepsin L-like precursor 0.0022 0.007 0.009
Mycobacterium tuberculosis Probable thioesterase TesA 0.0556 0.3385 0.5492
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0136 0.1047
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0189 0.0235
Mycobacterium ulcerans oxidoreductase 0.0041 0.0189 0.0235
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0053 0.0429
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0026 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Leishmania major DNA polymerase eta, putative 0.002 0.0053 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Onchocerca volvulus 0.0033 0.0139 0.0094
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0026 0.0031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0214 0.0488
Mycobacterium ulcerans thioesterase 0.0556 0.3385 0.5492
Loa Loa (eye worm) hypothetical protein 0.0041 0.0189 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0136 0.1375
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0028 0.021
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0168 0.0972 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0998 0.6125 1
Mycobacterium leprae Probable oxidireductase 0.0041 0.0189 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0189 0.0235
Echinococcus granulosus intermediate filament protein 0.0026 0.0095 0.017
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0556 0.3385 0.5506
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0045 0.0437
Mycobacterium ulcerans dehydrogenase 0.0041 0.0189 0.0235
Brugia malayi Cathepsin L-like precursor 0.0033 0.0139 0.0179
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0189 0.1579
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0053 0.0107
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0168 0.0972 0.1248
Leishmania major cathepsin L-like protease 0.0033 0.0139 0.0969
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0189 0.0235
Onchocerca volvulus 0.0026 0.0095 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0647 0.3949 0.642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.007 0.0574
Mycobacterium ulcerans short-chain dehydrogenase 0.0045 0.0212 0.0274
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0053 0.0069
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.4134 0.8251
Loa Loa (eye worm) hypothetical protein 0.0041 0.0189 0.0274
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0045 0.009
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0189 0.0235
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0401 0.078
Loa Loa (eye worm) hypothetical protein 0.0374 0.2253 0.3269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0012 0.0078
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0667 0.4076 0.6629
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0019 0.0025
Schistosoma mansoni smad 0.0017 0.0037 0.0073
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0053 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Onchocerca volvulus 0.0052 0.0252 0.0247
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0053 0.0012
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0029 0.0037
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0189 0.1942
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0045 0.0155
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0042 0.0193 0.1752
Schistosoma mansoni ap endonuclease 0.0018 0.0046 0.0091
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0189 0.415
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0189 0.415
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0189 0.0235
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0479 0.2908 0.4709
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.021 0.0399
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0038 0.0367
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0441 0.2672 0.4319
Echinococcus multilocularis cathepsin L 0.0017 0.0038 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0189 0.0274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0078
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0136 0.0272
Brugia malayi hypothetical protein 0.0036 0.0155 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0028 0.0283
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0053 0.0012
Schistosoma mansoni cpg binding protein 0.0061 0.0308 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.0193 0.0242
Plasmodium vivax unspecified product 0.0017 0.0038 0.0395
Brugia malayi N-terminal motif family protein 0.0189 0.1103 0.1416
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.019 0.4199
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.035 0.05
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0045 0.0069
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0046 0.0365
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.035 0.86
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0139 0.1158
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0038 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0011
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0136 0.0308
Onchocerca volvulus 0.0033 0.0139 0.0094
Brugia malayi Cathepsin L-like precursor 0.0022 0.007 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0139 0.1158
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0037 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Leishmania major hypothetical protein, conserved 0.0042 0.0193 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.007 0.0574
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0214 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0078
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0045 0.0153
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0019 0.0028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0026 0.0015
Onchocerca volvulus 0.0033 0.0139 0.0094
Schistosoma mansoni cpg binding protein 0.0057 0.0288 0.0575
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0288 0.0418
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0038 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0077
Leishmania major oxidoreductase-like protein 0.0041 0.0189 0.1399
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0045 0.009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0667 0.4076 0.6629
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0709 0.4333 0.7052
Brugia malayi Cathepsin L-like precursor 0.0033 0.0139 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0053 0.0549
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.015 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0723 0.7439
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0401 0.078
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0041 0.0189 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0522
Brugia malayi PAS domain containing protein 0.0015 0.0028 0.0035
Mycobacterium tuberculosis Hypothetical protein 0.0201 0.118 0.1865
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0189 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0045 0.036
Schistosoma mansoni Smad4 0.0017 0.0037 0.0073

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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