TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.324 | Formula: C17H20Cl2N2O2S
H donors: 0 H acceptors: 2 LogP: 4.49 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)c1sc(=O)n(c1C)Cc1ccc(c(c1)Cl)Cl)C
InChi: 1S/C17H20Cl2N2O2S/c1-4-5-8-20(3)16(22)15-11(2)21(17(23)24-15)10-12-6-7-13(18)14(19)9-12/h6-7,9H,4-5,8,10H2,1-3H3
InChiKey: FXPKQVFUTRPOQH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.3602	1
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0208	0.0579
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.3602	0.3602
Trypanosoma brucei	glucose transporter 1E	0.0016	0	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.3602	1
Leishmania major	glucose transporter, lmgt3	0.0016	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0208	0.0579
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.3602	1
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0071	1	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	hypothetical protein	0.0017	0.0208	0.0579
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.3602	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.3602	0.3602
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0208	0.0208
Leishmania major	hypothetical protein, conserved	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.3602	1
Onchocerca volvulus		0.0017	0.0208	0.0579
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.3602	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0208	0.0579
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trypanosoma cruzi	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Schistosoma mansoni	nuclear receptor	0.0017	0.0208	0.0579
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0208	0.0208
Brugia malayi	steroid hormone receptor	0.0036	0.3602	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0036	0.3602	0.3602
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0208	0.0579
Schistosoma mansoni	coup transcription factor	0.0036	0.3602	1
Brugia malayi	nuclear hormone receptor	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0208	0.0579
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.3602	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	hypothetical protein	0.0017	0.0208	0.0579
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.3602	0.3602
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.3602	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0208	0.0579
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.3602	1
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.3602	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0016	0	0.5
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0	0.5
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.3602	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0572	0.1588
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0208	0.0208
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0572	0.1588
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0208	0.0579
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.3602	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0208	0.0579
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.3602	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0	0.5
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.3602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Leishmania major	glucose transporter, lmgt1	0.0016	0	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.3602	0.3602
Trypanosoma cruzi	glucose transporter, putative	0.0016	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0208	0.0579
Brugia malayi	hypothetical protein	0.0019	0.0572	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0017	0.0208	0.0579
Onchocerca volvulus		0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0016	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.3602	0.3602
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	conserved hypotetical protein	0.0017	0.0208	0.0579
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0208	0.0208
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.3602	0.3602
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.3602	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.3602	0.3602
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Toxoplasma gondii	sugar transporter ST3	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Toxoplasma gondii	facilitative glucose transporter GT1	0.0016	0	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.3602	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.3602	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.3602	0.3602
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.3602	0.3602
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Trypanosoma brucei	glucose transporter 2A	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0208	0.0208
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Brugia malayi	hypothetical protein	0.0019	0.0572	0.1588
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Giardia lamblia	Sugar-proton symporter	0.0016	0	0.5
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0572	0.1588
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.3602	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0208	0.0579
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Brugia malayi	ecdysteroid receptor	0.0036	0.3602	1
Trypanosoma brucei	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.3602	1
Brugia malayi	nuclear receptor RXR	0.0017	0.0208	0.0579
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0208	0.0579
Trichomonas vaginalis	glucose transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0	0.5
Brugia malayi	ecdysone receptor	0.0017	0.0208	0.0579
Toxoplasma gondii	sugar transporter ST2	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.3602	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.3602	0.3602
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.3602	0.3602
Plasmodium falciparum	hexose transporter	0.0016	0	0.5
Brugia malayi	nuclear receptor RXR	0.0019	0.0572	0.1588
Brugia malayi	nuclear hormone receptor	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Plasmodium vivax	hexose transporter	0.0016	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0208	0.0579
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.3602	1
Schistosoma mansoni	zinc finger protein	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0208	0.0579
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.3602	0.3602
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0208	0.0208
Mycobacterium ulcerans	sugar transporter	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.3602	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0572	0.1588
Brugia malayi	tailless protein	0.0017	0.0208	0.0579
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trypanosoma cruzi	hexose transporter	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Plasmodium vivax	sugar transporter, putative	0.0016	0	0.5
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Giardia lamblia	Hexose transporter	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0208	0.0579
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Toxoplasma gondii	sugar transporter ST1	0.0016	0	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Onchocerca volvulus		0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Schistosoma mansoni	nuclear receptor	0.0017	0.0208	0.0579
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0572	0.1588
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.3602	0.3602
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0572	0.0572
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.3602	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.3602	1
Loa Loa (eye worm)	DR-78	0.0017	0.0208	0.0579
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0	0.5
Leishmania major	glucose transporter, lmgt2	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0036	0.3602	1
Trichomonas vaginalis	glucose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0208	0.0579

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1901924

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1540290