Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor coactivator 3 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear receptor coactivator 1 | Starlite/ChEMBL | No references |
Herpes simplex virus (type 1 / strain 17) | Alpha trans-inducing protein (VP16) | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4365 | 0.3045 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3782 | 0.2326 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.626 | 0.3985 |
Brugia malayi | hypothetical protein | 0.003 | 0.1898 | 0.1898 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7133 | 0.6462 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3782 | 0.3782 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.7722 | 0.7188 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.626 | 0.3985 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0064 | 0.7777 | 0.7257 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1898 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4365 | 0.3045 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7133 | 0.7133 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0064 | 0.7777 | 0.4057 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7133 | 0.7133 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0045 | 0.442 | 0.1026 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1898 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.626 | 0.626 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0064 | 0.7777 | 0.4057 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.626 | 0.3985 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4365 | 0.3045 |
Brugia malayi | hypothetical protein | 0.0045 | 0.442 | 0.442 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0045 | 0.442 | 0.442 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1898 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1898 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0044 | 0.4365 | 0.4365 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1898 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7133 | 0.6462 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4365 | 0.3045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1898 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4365 | 0.4365 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1898 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1898 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0045 | 0.442 | 0.3113 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.626 | 0.5384 |
Brugia malayi | hypothetical protein | 0.0064 | 0.7722 | 0.7722 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0045 | 0.442 | 0.442 |
Onchocerca volvulus | 0.0064 | 0.7722 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.276 uM | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 6.265 uM | PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 12.653 uM | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.