Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.3336 | 1 |
Brugia malayi | hypothetical protein | 0.0124 | 0.1279 | 0.0963 |
Entamoeba histolytica | aminopeptidase, putative | 0.0124 | 0.1279 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.3336 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0124 | 0.1279 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.3336 | 0.3825 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0093 | 0.035 | 0.105 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3336 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3336 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3336 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.6362 | 0.7295 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.8721 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3336 | 1 |
Onchocerca volvulus | 0.0422 | 1 | 1 | |
Onchocerca volvulus | 0.0195 | 0.3336 | 0.2358 | |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0124 | 0.1279 | 0.3835 |
Echinococcus granulosus | aminopeptidase N | 0.0422 | 1 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0124 | 0.1279 | 0.3835 |
Brugia malayi | Peptidase family M1 containing protein | 0.0124 | 0.1279 | 0.0963 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0124 | 0.1279 | 0.1279 |
Echinococcus multilocularis | aminopeptidase N | 0.0422 | 1 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0124 | 0.1279 | 0.3835 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.3336 | 0.2358 |
Loa Loa (eye worm) | aminopeptidase N | 0.0124 | 0.1279 | 0.1467 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0127 | 0.1361 | 0.4079 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3336 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3336 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0124 | 0.1279 | 0.1279 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0124 | 0.1279 | 0.3835 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0342 | 0.7641 | 0.8762 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.3336 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0124 | 0.1279 | 0.1279 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.3336 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0124 | 0.1279 | 0.1279 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.3336 | 0.3336 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0124 | 0.1279 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0124 | 0.1279 | 0.1279 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0124 | 0.1279 | 1 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.3336 | 0.3094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.74 uM | Compound was evaluated for the inhibition of human Thymidylate Synthase | ChEMBL. | 1895294 |
I50 (functional) | = 4.5 uM | Compound was evaluated for inhibition of MTX influx into MOLT-4 cells | ChEMBL. | 1895294 |
I50 (functional) | = 9 uM | Compound was evaluated for inhibition of tumor cell growth in Manca human lymphoma cell line | ChEMBL. | 1895294 |
I50 (functional) | = 22 uM | Compound was evaluated for inhibition of tumor cell growth in MCF-7 cell line | ChEMBL. | 1895294 |
I50 (functional) | > 100 uM | Compound was evaluated for inhibition of tumor cell growth in SW/480 cell line | ChEMBL. | 1895294 |
IC50 (binding) | = 0.74 uM | Compound was evaluated for the inhibition of human Thymidylate Synthase | ChEMBL. | 1895294 |
IC50 (functional) | = 4.5 uM | Compound was evaluated for inhibition of MTX influx into MOLT-4 cells | ChEMBL. | 1895294 |
IC50 (functional) | = 9 uM | Compound was evaluated for inhibition of tumor cell growth in Manca human lymphoma cell line | ChEMBL. | 1895294 |
IC50 (functional) | = 22 uM | Compound was evaluated for inhibition of tumor cell growth in MCF-7 cell line | ChEMBL. | 1895294 |
IC50 (functional) | > 100 uM | Compound was evaluated for inhibition of tumor cell growth in SW/480 cell line | ChEMBL. | 1895294 |
Km (binding) | = 43.7 uM | Apparent kinetic constant of substrate activity for Hog liver Folyl-polyglutamate synthase | ChEMBL. | 1895294 |
Km (binding) | = 43.7 uM | Apparent kinetic constant of substrate activity for Hog liver Folyl-polyglutamate synthase | ChEMBL. | 1895294 |
Ratio (binding) | = 0.38 | It is the ratio of apparent kinetic constant to that of relative maximum velocity | ChEMBL. | 1895294 |
Vmax (binding) | = 16.5 % | Relative maximum velocity of substrate activity for Hog liver Folyl-polyglutamate synthase (relative to control of 50 microM aminopterin) | ChEMBL. | 1895294 |
Vmax (binding) | = 16.5 % | Relative maximum velocity of substrate activity for Hog liver Folyl-polyglutamate synthase (relative to control of 50 microM aminopterin) | ChEMBL. | 1895294 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 1895294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.