Detailed information for compound 1540531

Basic information

Technical information
  • TDR Targets ID: 1540531
  • Name: ethyl 4-[(furan-2-ylmethyl-(3-piperidin-1-ylp ropyl)carbamothioyl)amino]benzoate
  • MW: 429.576 | Formula: C23H31N3O3S
  • H donors: 1 H acceptors: 1 LogP: 3.76 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=S)N(Cc1ccco1)CCCN1CCCCC1
  • InChi: 1S/C23H31N3O3S/c1-2-28-22(27)19-9-11-20(12-10-19)24-23(30)26(18-21-8-6-17-29-21)16-7-15-25-13-4-3-5-14-25/h6,8-12,17H,2-5,7,13-16,18H2,1H3,(H,24,30)
  • InChiKey: YANXJXWDQWUQGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[[2-furylmethyl-[3-(1-piperidyl)propyl]carbamothioyl]amino]benzoate
  • 4-[[[2-furylmethyl-[3-(1-piperidyl)propyl]amino]-thioxomethyl]amino]benzoic acid ethyl ester
  • 4-[(2-furylmethyl-(3-piperidinopropyl)thiocarbamoyl)amino]benzoic acid ethyl ester
  • MLS000586282
  • SMR000204645
  • ethyl 4-({[(2-furylmethyl)(3-piperidin-1-ylpropyl)amino]carbonothioyl}amino)benzoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0139 0.0491 0.1398
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.01 0.0332 0.0982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Plasmodium vivax vivapain-1 0.0239 0.0906 0.5168
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0146 0.0432
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0093
Schistosoma mansoni hypothetical protein 0.0731 0.294 0.8693
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.01 0.0332 0.1873
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1129 0.5
Plasmodium falciparum cysteine proteinase falcipain 1 0.0239 0.0906 0.5168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Echinococcus multilocularis cysteine protease 0.0442 0.1747 0.1747
Leishmania major DNA polymerase eta, putative 0.0031 0.0044 0.0133
Loa Loa (eye worm) hypothetical protein 0.0304 0.1173 0.3461
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.0332 0.097
Onchocerca volvulus 0.0442 0.1747 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0118 0.035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0231 0.0625
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Schistosoma mansoni bromodomain containing protein 0.0064 0.0184 0.0544
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0036 0.0412
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0093
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.01 0.0332 0.1873
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.01 0.0332 0.1873
Brugia malayi MH2 domain containing protein 0.0144 0.0514 0.1465
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0173
Brugia malayi cathepsin L-like precursor 0.0304 0.1173 0.3428
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.01 0.0332 0.1873
Toxoplasma gondii preprocathepsin c precursor, putative 0.01 0.0332 0.18
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.0084
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0239 0.0906 0.2678
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.042
Loa Loa (eye worm) hypothetical protein 0.018 0.066 0.1942
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Echinococcus granulosus cathepsin L 0.01 0.0332 0.0982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.01 0.0332 0.1599
Onchocerca volvulus 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Trypanosoma cruzi cysteine proteinase, putative 0.0239 0.0906 0.2632
Echinococcus multilocularis cathepsin L cysteine protease 0.0442 0.1747 0.1747
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0509 0.6024
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0442 0.1747 0.516
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0063 0.0123
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Onchocerca volvulus 0.0035 0.0063 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Loa Loa (eye worm) hypothetical protein 0.0076 0.0231 0.0672
Echinococcus multilocularis cathepsin L 0.0239 0.0906 0.0906
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0036 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus cathepsin l1 0.0304 0.1173 0.347
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0098 0.0228
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0063 0.0173
Trichomonas vaginalis glutaminase, putative 0.0278 0.1069 0.5973
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.01 0.0332 0.1873
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0063 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0043
Brugia malayi Bromodomain containing protein 0.0039 0.0079 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.01 0.0332 0.1873
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0239 0.0906 0.5125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Plasmodium falciparum serine repeat antigen 6 0.01 0.0332 0.1873
Mycobacterium ulcerans lipase LipD 0.0035 0.0063 0.0533
Loa Loa (eye worm) cathepsin B 0.0328 0.1275 0.3763
Onchocerca volvulus Cathepsin L homolog 0.0442 0.1747 1
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0169 0.05
Echinococcus granulosus cathepsin l1 0.0442 0.1747 0.5166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0491 0.1441
Loa Loa (eye worm) hypothetical protein 0.0139 0.0491 0.1441
Brugia malayi jmjC domain containing protein 0.0071 0.0211 0.0565
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0509 0.4736
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.0709 0.2097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.01 0.0332 0.0982
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0332 0.0925
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0036 0.0282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0239 0.0906 0.5125
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0514 0.1508
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0376 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Entamoeba histolytica cysteine proteinase, putative 0.0304 0.1173 0.6648
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0063 0.0185
Schistosoma mansoni cathepsin S (C01 family) 0.01 0.0332 0.0982
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0006 0.0057
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0063 0.0239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0036 0.0412
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.016 0.145
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.016 0.0804
Loa Loa (eye worm) hypothetical protein 0.0043 0.0097 0.0275
Mycobacterium leprae Probable lipase LipE 0.0035 0.0063 0.0565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0063 0.0729
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0442 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Toxoplasma gondii cathepsin B 0.0328 0.1275 0.7266
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0044 0.0133
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0098 0.0444
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.01 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0376 0.1102
Plasmodium vivax serine-repeat antigen (SERA), putative 0.01 0.0332 0.1873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Toxoplasma gondii ABC1 family protein 0.0035 0.0063 0.0239
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0838 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Onchocerca volvulus 0.0049 0.0118 0.0482
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0729
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0063 0.0729
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0139 0.0491 0.1398
Brugia malayi Papain family cysteine protease containing protein 0.0442 0.1747 0.5135
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0219 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0332 0.1599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0063 0.0063
Onchocerca volvulus 0.0035 0.0063 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0063 0.0123
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0146 0.0432
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Onchocerca volvulus 0.0442 0.1747 1
Toxoplasma gondii cathepsin CPC2 0.01 0.0332 0.18
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0063 0.0123
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0906 0.2632
Mycobacterium ulcerans hypothetical protein 0.0029 0.0036 0.0282
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0838 0.3382 1
Plasmodium falciparum serine repeat antigen 2 0.01 0.0332 0.1873
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0012 0.0037
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0118 0.035
Toxoplasma gondii cathepsin CPL 0.0442 0.1747 1
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Trypanosoma cruzi cysteine peptidase, putative 0.0139 0.0491 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.01 0.0332 0.1599
Echinococcus multilocularis GPCR, family 2 0.0035 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Schistosoma mansoni DNA polymerase eta 0.0044 0.0098 0.029
Trypanosoma cruzi cysteine peptidase, putative 0.0239 0.0906 0.2632
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.0332 0.097
Plasmodium vivax serine-repeat antigen (SERA) 0.01 0.0332 0.1873
Entamoeba histolytica cysteine proteinase, putative 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0625
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Plasmodium vivax vivapain-2 0.0442 0.1747 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0376 0.1057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0239 0.0906 0.2678
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0146 0.0372
Brugia malayi cathepsin L-like cysteine proteinase 0.01 0.0332 0.0925
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0098 0.0228
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.016 0.0474
Brugia malayi glutaminase DH11.1 0.0278 0.1069 0.3117
Onchocerca volvulus 0.0442 0.1747 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.01 0.0332 0.1873
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Entamoeba histolytica cysteine proteinase 1, putative 0.0239 0.0906 0.5083
Entamoeba histolytica hypothetical protein 0.01 0.0332 0.1731
Entamoeba histolytica papain family cysteine protease domain containing protein 0.01 0.0332 0.1731
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.01 0.0332 0.0982
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0376 0.1102
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0169 0.0169
Schistosoma mansoni cathepsin s 0.0139 0.0491 0.1452
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.01 0.0332 0.097
Echinococcus multilocularis cathepsin b 0.0838 0.3382 0.3382
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Schistosoma mansoni hypothetical protein 0.0076 0.0231 0.0684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0304 0.1173 0.6594
Onchocerca volvulus Cathepsin L homolog 0.01 0.0332 0.1731
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0906 0.2632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Brugia malayi Cathepsin L-like cysteine proteinase 0.0304 0.1173 0.3428
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0063 0.0186
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.016 0.0474
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0838 0.3382 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.01 0.0297
Echinococcus multilocularis geminin 0.0731 0.294 0.294
Loa Loa (eye worm) cysteine protease 0.0442 0.1747 0.516
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0491 0.1441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0332 0.0925
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0282
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0063 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0063 0.0185
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0332 0.0925
Entamoeba histolytica cysteine proteinase, putative 0.0442 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.01 0.0332 0.0925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Giardia lamblia Cathepsin B precursor 0.0328 0.1275 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0063 0.0565
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0328 0.1275 0.7199
Plasmodium vivax vivapain-3 0.0239 0.0906 0.5168
Onchocerca volvulus 0.01 0.0332 0.1731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.01 0.0332 0.1873
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0219 0.0649
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Echinococcus multilocularis cathepsin L cysteine protease 0.0442 0.1747 0.1747
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Echinococcus granulosus cathepsin b 0.0838 0.3382 1
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Brugia malayi mbt repeat family protein 0.0049 0.0118 0.0289
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0239 0.0906 0.2632
Entamoeba histolytica cysteine protease, putative 0.0442 0.1747 1
Leishmania major hypothetical protein, conserved 0.0035 0.0063 0.0239
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0118 0.0338
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0211 0.0625
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0221
Echinococcus granulosus cathepsin L cysteine proteinase 0.0442 0.1747 0.5166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.01 0.0297
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0211 0.0625
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0211 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.0084
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Onchocerca volvulus 0.0035 0.0063 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.01 0.0297
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.01 0.0332 0.1599
Brugia malayi cathepsin L precursor 0.01 0.0332 0.0925
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0063 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0219 0.0649
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0063 0.0123
Onchocerca volvulus 0.018 0.066 0.3649
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.01 0.0297
Plasmodium falciparum serine repeat antigen 1 0.01 0.0332 0.1873
Giardia lamblia Cathepsin B precursor 0.0328 0.1275 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0838 0.3382 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0442 0.1747 0.1747
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Echinococcus granulosus GPCR family 2 0.0035 0.0063 0.0186
Loa Loa (eye worm) hypothetical protein 0.0442 0.1747 0.516
Echinococcus multilocularis cathepsin L 0.01 0.0332 0.0332
Onchocerca volvulus 0.0442 0.1747 1
Brugia malayi Cathepsin L-like precursor 0.0304 0.1173 0.3428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0332 0.1599
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0063 0.0729
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0304 0.1173 0.6594
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.01 0.0332 0.1873
Onchocerca volvulus 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus cathepsin b 0.0838 0.3382 1
Schistosoma mansoni cathepsin F (C01 family) 0.0442 0.1747 0.5166
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0211 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Brugia malayi beta-lactamase family protein 0.0035 0.0063 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.016 0.0474
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.01 0.0332 0.1873
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0036 0.0282
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Loa Loa (eye worm) glutaminase 0.0278 0.1069 0.3151
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0442 0.1747 0.5166
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0063 0.0325
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Loa Loa (eye worm) MBCTL1 0.0055 0.0146 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0004 0.0004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.01 0.0332 0.1731
Echinococcus granulosus cathepsin L 0.0239 0.0906 0.2678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Loa Loa (eye worm) glutaminase 2 0.0278 0.1069 0.3151
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0036 0.0282
Loa Loa (eye worm) hypothetical protein 0.0304 0.1173 0.3461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Plasmodium vivax unspecified product 0.01 0.0332 0.1873
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.016 0.0804
Brugia malayi cathepsin F-like cysteine proteinase 0.0139 0.0491 0.1398
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0063 0.0729
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Brugia malayi jmjC domain containing protein 0.0073 0.0219 0.0589
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0043
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0118 0.0482
Loa Loa (eye worm) hypothetical protein 0.0139 0.0491 0.1441
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0118 0.0118
Onchocerca volvulus Cathepsin F homolog 0.0442 0.1747 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.016 0.1884
Echinococcus granulosus dna polymerase eta 0.0044 0.0098 0.029
Giardia lamblia Cathepsin B precursor 0.0328 0.1275 1
Trypanosoma cruzi cysteine proteinase, putative 0.0239 0.0906 0.2632
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0063 0.0123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0219 0.0649
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Brugia malayi Bromodomain containing protein 0.0076 0.0233 0.0631
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0118 0.035
Brugia malayi Cathepsin L-like precursor 0.0304 0.1173 0.3428
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.01 0.0332 0.1873
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0277
Onchocerca volvulus Cathepsin L homolog 0.0442 0.1747 1
Leishmania major cysteine peptidase A (CPA) 0.0442 0.1747 1
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Brugia malayi cathepsin Z-like cysteine proteinase 0.01 0.0332 0.0925
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0328 0.1275 0.3731
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0442 0.1747 0.516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0282
Echinococcus granulosus geminin 0.0731 0.294 0.8693
Mycobacterium ulcerans hypothetical protein 0.0035 0.0063 0.0533
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0118 0.035
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0332 0.1599
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.01 0.01
Plasmodium vivax vivapain-2 0.0442 0.1747 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.016 0.145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Trypanosoma cruzi cruzipain precursor, putative 0.0139 0.0491 0.1398
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0093
Plasmodium falciparum cysteine proteinase falcipain 3 0.0442 0.1747 1
Schistosoma mansoni cathepsin B (C01 family) 0.01 0.0332 0.0982
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0328 0.1275 0.3771
Schistosoma mansoni hypothetical protein 0.0295 0.1139 0.3367
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0146 0.0432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0906 0.5005
Loa Loa (eye worm) fibroinase 0.0442 0.1747 0.516
Schistosoma mansoni hypothetical protein 0.0731 0.294 0.8693
Brugia malayi PHD-finger family protein 0.0025 0.0022 0.0003
Trypanosoma cruzi cruzipain precursor, putative 0.0442 0.1747 0.5135
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0063 0.0172
Echinococcus multilocularis cysteine protease 0.0442 0.1747 0.1747
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.01 0.0297
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0118 0.0118
Mycobacterium ulcerans glutaminase 0.0278 0.1069 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0514 0.1508
Plasmodium falciparum serine repeat antigen 3 0.01 0.0332 0.1873
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.005
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0044 0.0068
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0509 1
Entamoeba histolytica cysteine proteinase 2 0.0239 0.0906 0.5083
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.0084
Brugia malayi hypothetical protein 0.018 0.066 0.1901
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.0709 0.0709
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0118 0.035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.016 0.016
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0006 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1129 0.845
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0063 0.0533
Loa Loa (eye worm) ctsf protein 0.0442 0.1747 0.516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0332 0.1599
Plasmodium falciparum serine repeat antigen 9 0.01 0.0332 0.1873
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0013
Plasmodium vivax serine-repeat antigen (SERA), putative 0.01 0.0332 0.1873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1129 0.6388
Plasmodium falciparum serine repeat antigen 5 0.01 0.0332 0.1873
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0063 0.0186
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0304 0.1173 0.3428
Brugia malayi beta-lactamase family protein 0.0035 0.0063 0.0123
Leishmania major DNA polymerase eta, putative 0.0044 0.0098 0.0444
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0063 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0332 0.1599
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Brugia malayi fibroinase precursor 0.01 0.0332 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.016 0.145
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0328 0.1275 0.7266
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0332 0.0925
Loa Loa (eye worm) beta-lactamase 0.0035 0.0063 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0063 0.0185
Echinococcus multilocularis dna polymerase eta 0.0044 0.0098 0.0098
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0146 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0021 0.0088
Schistosoma mansoni cathepsin F (C01 family) 0.0442 0.1747 0.5166
Plasmodium falciparum serine repeat antigen 4 0.01 0.0332 0.1873
Brugia malayi cathepsin F-like cysteine proteinase 0.01 0.0332 0.0925
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.01 0.0332 0.1599
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0012 0.0037
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1129 0.6388
Onchocerca volvulus 0.0304 0.1173 0.6648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.01 0.0235
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Onchocerca volvulus 0.0442 0.1747 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Brugia malayi cathepsin Z-like cysteine proteinase 0.01 0.0332 0.0925
Brugia malayi cathepsin B-like cysteine proteinase 0.0838 0.3382 1
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Toxoplasma gondii cathepsin CPC1 0.01 0.0332 0.18
Echinococcus multilocularis cathepsin b 0.0838 0.3382 0.3382
Trypanosoma cruzi cysteine protease, putative 0.0239 0.0906 0.2632
Plasmodium vivax serine-repeat antigen (SERA) 0.01 0.0332 0.1873
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Loa Loa (eye worm) hypothetical protein 0.0304 0.1173 0.3461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Brugia malayi beta-lactamase 0.0035 0.0063 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0282
Plasmodium falciparum serine repeat antigen 8 0.01 0.0332 0.1873
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.01 0.0332 0.0982
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Loa Loa (eye worm) hypothetical protein 0.0838 0.3382 1
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Plasmodium vivax unspecified product 0.0139 0.0491 0.2787
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0063 0.0533
Schistosoma mansoni cathepsin C 0.01 0.0332 0.0982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus cathepsin L cysteine protease 0.0239 0.0906 0.2678
Brugia malayi mbt repeat family protein 0.0049 0.0118 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Schistosoma mansoni cathepsin F (C01 family) 0.0304 0.1173 0.347
Echinococcus granulosus cysteine protease 0.0239 0.0906 0.2678
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0845 1
Schistosoma mansoni glutaminase 0.0278 0.1069 0.316
Plasmodium vivax unspecified product 0.0239 0.0906 0.5168
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0069 0.0204
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0043
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0004 0.0012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0442 0.1747 0.1747
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Plasmodium falciparum serine repeat antigen 7 0.01 0.0332 0.1873
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Trypanosoma brucei cysteine peptidase C (CPC) 0.0328 0.1275 0.7266
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0729
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0251
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0729
Mycobacterium ulcerans beta-lactamase 0.0035 0.0063 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0906 0.5005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0088
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0239 0.0906 0.2678
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0838 0.3382 1
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0332 0.0925
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0146 0.0146

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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