Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0371 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0133 | 0.3131 | 0.3113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3131 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0865 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.3131 | 0.3113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0865 | 0.0841 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0297 | 0.0949 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0026 | 0.0083 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0026 | 0.0083 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0026 | 0.0083 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0026 | 0.0083 |
Echinococcus granulosus | smad | 0.0025 | 0.0026 | 0.0083 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.3131 | 0.3113 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.3131 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3131 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0309 | 0.0284 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0026 | 0.0083 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0865 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0865 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0026 | 0.0083 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0026 | 0.0083 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.3131 | 0.3113 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.076 | 0.0736 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.3131 | 0.3113 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0026 | 0.0083 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0865 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0026 | 0.0083 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0865 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.076 | 0.0736 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0865 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0026 | 0.0083 |
Schistosoma mansoni | smad | 0.0025 | 0.0026 | 0.0083 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3131 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0865 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3131 | 1 |
Echinococcus multilocularis | smad | 0.0025 | 0.0026 | 0.0083 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0865 | 0.0841 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.3131 | 0.3113 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0026 | 0.0083 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0371 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.076 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0297 | 0.0272 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0865 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0297 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.076 | 0.0736 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.3131 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.